China
Africa
Explore chapters and articles related to this topic
Gallstone Disease/Cholelithiasis/Cholecystitis
Published in Charles Theisler, Adjuvant Medical Care, 2023
Nutritional Supplements: Lecithin is found naturally in bile, where it helps to keep cholesterol in solution. In theory, supplementing with lecithin might help prevent cholesterol from crystallizing in the gall bladder. In one study of eight patients with gallstones who took lecithin for 18–34 months, the stones decreased in size in one case and remained the same in others.5,6
Animal Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Dietary phospholipids or lecithin in egg yolk have emerged as a potential source of bioactive lipids that may have widespread effects on pathways related to inflammation, cholesterol metabolism, and HDL function (117). Lecithin is also necessary for the functioning of a number of tissues and organs such as brain, lungs, blood, bile, and more. Large intakes of dietary lecithin have long been known to influence serum cholesterol levels in humans by inhibiting cholesterol absorption when cholesterol is in significant amounts in the diet (117).
Micronutrient Supplementation and Ergogenesis — Metabolic Intermediates
Published in Luke Bucci, Nutrients as Ergogenic Aids for Sports and Exercise, 2020
Even though both lecithin and choline supplementations have been shown to greatly increase blood choline levels,546,547 few studies have been performed to correlate the increased blood levels with changes in transmethylation activity, creatine synthesis, or physical performance. Future research must take into account the low and variable phosphatidyl choline content of commercial lecithin548 and the diarrhea and foul-smelling intestinal gas production from 20 g of choline base supplementation, although lower doses appeared safe.549 Pure phosphatidyl choline and choline bitartrate forms may offer compatible supplements for future testing.
Anthocran® Phytosome®: Prevention of Recurring Urinary Infections and Symptoms after Catheterization
Published in Journal of Dietary Supplements, 2023
Roberto Cotellese, Andrea Ledda, Gianni Belcaro, Maria R. Cesarone, Claudia Scipione, Valeria Scipione, Mark Dugall, Beatrice Feragalli, Antonella Riva, Pietro Allegrini, Giovanna Petrangolini, Stefano Togni
In the study, a specific control group supplemented with lecithin alone was not included. Nevertheless, the use of lecithin as emulsifier, stabilizer, dispersing aid, and release agent is acknowledged as the molecule is recognized as a safe and inactive compound (35). Lecithin has been used as excipient in a study evaluating the antibiotic resistance to urinary infections in mice, with no specific reports of involvement in any mechanism but the generation of an oral dispersion to favor administration (36). In addition, in human patients, lecithin has been tested as a coating agent for catheter and its presence has not reported to be associated to any specific effect (37). The cranberry PS supplement showed significantly superior results in the reduction of UTI symptoms, hematuria and bacterial contamination compared with SM or treatment with nitrofurantoin and prevented the re-occurrence of UTIs in the 3 months following treatment.
Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, in vitro, and in vivo evaluation
Published in Drug Delivery, 2022
Wedad Sakran, Rania S. Abdel-Rashid, Fatma Saleh, Raghda Abdel-Monem
Ethosomal dispersions encapsulating DOM were formulated according to the method developed by Touitou et al. (2001) with modification as it is simple and most popular method used in preparing ethosomal systems. The organic and aqueous phases were prepared separately. The organic phase containing lecithin and DOM dissolved in ethanol at room temperature under vigorous stirring (1200 rpm) by means of magnetic stirrer. PG followed by water was then added dropwise using syringe and the mixture was agitated at 700 rpm for 30 min to produce the requisite ethosomal suspension (El-Shenawy et al., 2019). The effect of replacing 10% of lecithin concentration with oleic acid or Labrafac® was studied. Addition of 2% (w/v) surfactant solution (span 60 and tween 80) to the aqueous or organic phase, respectively, was investigated too. The obtained suspension was sonicated using probe sonicator ultrasonic processor (UP50H, Hielscher, Teltow, Germany) with frequency 20 kHz at 4 °C for 5 min. Formulations were stored in the refrigerator and evaluated for vesicular size, ZP, %EE, and Q6h. Table 2 displays composition of different formulations based on the different screened variables.
Long-circulating doxorubicin and schizandrin A liposome with drug-resistant liver cancer activity: preparation, characterization, and pharmacokinetic
Published in Journal of Liposome Research, 2022
Shi-Yi Xu, Hui Su, Xing-Yu Zhu, Xue-Ying Li, Jie Li, Xi Chen, Qi Wang, Ruo-Yi Hao, Xue-Ying Yan
Phospholipid is an important part of lipid preparation. Different kinds of phospholipids will affect the encapsulation efficiency of the preparation after hydration. Natural lecithin was chosen because of its good biocompatibility, high safety and low price. The commonly used natural lecithin is egg yolk lecithin, hydrogenated phospholipids and soybean lecithin. Single factor study was used to determine whether high purity soybean lecithin (PC 80% and 95%, injection grade), hydrogenated phospholipids (PC200sh, injection grade), natural yolk phospholipids (Lipoid EPCs, Ludwigshafen, Germany, injection grade) and hydrogenated phospholipids (Lipoid SPC-3, injection grade) were suitable for the preparation of liposomes. The results showed that the liposomes prepared from Lipoid EPCS were very unstable and easy to be stratified. PC200sh and lipoid SPC-3 are hydrogenated phospholipids with high phase transition temperature, poor solubility in organic solvents, and white particles appear during hydration. Soybean lecithin has good solubility, and the prepared liposomes were uniform and stable. The encapsulation efficiency of compound liposomes prepared by soybean lecithin with 95% purity of PC was higher. PC could form complex with drugs to increase the solubility of drugs and the stability of preparations. Hence, we chose soya lecithin with purity of 95% in injection grade.