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Role of Natural Agents in the Management of Diabetes
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Monika Elżbieta Jach, Anna Serefko
Lagerstroemia speciosa is a plant whose leaves are used in folk medicine as a remedy for diabetes in many parts of the world, especially in Southeast Asia. The major bioactive compounds of banaba leaves are corosolic acid and ellagitannins. Corosolic acid has also been isolated from several other plants. Banaba also contains tannins and terpene acids (e.g., oleanolic acid) (Klein et al., 2007; Miura et al., 2012).
Nutraceutical Herbs and Insulin Resistance
Published in Robert E.C. Wildman, Richard S. Bruno, Handbook of Nutraceuticals and Functional Foods, 2019
Giuseppe Derosa, Pamela Maffioli
Lagerstroemia speciosa, commonly known as banaba, is a tropical plant found in many parts of Southeast Asia. In the Philippines, dried banaba leaves are used for the treatment of diabetes and kidney diseases. Many in vivo and in vitro studies have confirmed the anti-diabetic activity of banaba. The mechanisms involved include increased glucose entry into cells, altered hydrolysis of sucrose and starches, and reduced gluconeogenesis. These activities are attributed to the corosolic acid and ellagitannins and mediated by the PPAR receptor, MAP-kinase, and other signal transducer factors. Supplementation with banaba has proven to be safe and well tolerated.57
Inhibiting the Absorption of Dietary Carbohydrates and Fats with Natural Products
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Faustino Garcia reported in 1941 that dried leaves or ripe fruits of Lagerstroemia speciosa (L.) Pers. (Figure 1.19) known in the Philippines as banaba at a dose of 20 g in the form decoction had the same activity as 7 units of insulin in decreasing blood glucose. The flowers at the same dose had activity equivalent to 5 units of insulin.92 Aqueous extract from leaves given orally at a dose of 150 mg/kg/day to streptozotocin-induced diabetic mice for 2 months had no effect up to 10 days treatment but decreased, after 60 days, glycaemia from 119.7 to 63 mg/dL, a value close to 58.1 mg/dL in normoglycaemic rodents.93 This treatment brought to normal values hepatic lipid peroxidation, glutathione-S-transferase, superoxide dismutase, and glutathione contents.93 From the leaves of Lagerstroemia speciosa (L.) Pers. the triterpenes oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, corosolic acid, and 23-hydroxyursolic acid inhibited α-glucosidase with IC50 values below 35 μg/mL.94,95 Out of these triterpene, corosolic acid inhibited α-amylase with an IC50 value of 100 μg/mL.94,95 Corosolic acid (Figure 1.20) given to spontaneous type 2 diabetic KK-Ay as 0.023% part of a high cholesterol diet for 10 weeks maintained plasma cholesterol to the level of control whereby it had no effect on weight gain.94 This treatment halved hepatic cholesterol content and decreased cholesterolaemia in oral cholesterol test to about 10% at 4 hours on probable account of ACAT-2 inhibition.94 Clinical trials are warranted.
Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats
Published in Drug and Chemical Toxicology, 2022
Thakur Rohit Singh, Devaraj Ezhilarasan
Lagerstroemia speciosa Pers., (Lythraceae) commonly known as Banaba (Pride of India) has been traditionally used to treat various ailments including diabetes and obesity (Stohs et al.2012). The leaves, stems, flowers, fruits, bark and roots of this plant contain a variety of phytocompounds like ellagic acids, glycosides, flavones, triterpenes (corosolic acid), and tannins, etc. (Stohs et al.2012, Tiwary et al.2017). The presence of corosolic acid in leaves of L. speciosa was attributed to beneficial effects (Jayakumar et al.2014, Rohit Singh and Ezhilarasan 2020, Zhang et al.2020). Previous in vivo studies have shown the anti-inflammatory, anti-diarrheal, and anti-gout effects of banaba (Stohs et al.2012). In the context of the liver, banaba petal extract attenuated carbon tetrachloride-induced oxidative stress and hepatotoxicity in mice (Tiwary et al.2017). Our recent in vitro studies have explored the pro-apoptotic and cell cycle arresting potential of ethanolic banaba leaf extract (EBLE) in liver cancer cells (Rohit Singh and Ezhilarasan 2020, Thakur and Devaraj 2020). Therefore, in this study, we investigated the antioxidant and hepatoprotective effect of EBLE against DDS-induced hepatotoxicity in rats.
Ethanolic Extract of Lagerstroemia Speciosa (L.) Pers., Induces Apoptosis and Cell Cycle Arrest in HepG2 Cells
Published in Nutrition and Cancer, 2020
T. Rohit Singh, D. Ezhilarasan
Ethanloic leaf extract of Lagerstroemia speciosa (L.) Pers., was extracted and obtained from M/s Quimico (Batch no. KAN/BE/1801009) Herbal Extract Manufacturer, Bengaluru, India. According to their certificate of analysis and high-performance liquid chromatography assay, ethanolic banaba leaves extract (EBLE) contains 20% corosolic acid.