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Role of Natural Agents in the Management of Diabetes
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Monika Elżbieta Jach, Anna Serefko
The hypoglycemic effect of hot water and methanol extracts of L. speciosa has been revealed in both numerous animal models and several human studies. Some studies are focused on corosolic acid originated from banaba leaves as a main bioactive substance responsible for antidiabetic properties. In these studies, purified corosolic acid is used as an isolate with an organic solvent (10 mg/30 days), and corosolic acid as a constituent of standardized banaba extracts (60 mg comprising 10 mg corosolic acid/2 weeks) (Park et al., 2011; Ulbricht et al., 2007). In other studies, there are ellagitannins in water-soluble fractions, which might have an activity similar to insulin, and tannins which have the antioxidant and glucose regulatory properties (Klein et al., 2007).
Nutraceutical Herbs and Insulin Resistance
Published in Robert E.C. Wildman, Richard S. Bruno, Handbook of Nutraceuticals and Functional Foods, 2019
Giuseppe Derosa, Pamela Maffioli
Banaba standardized to 1% of corosolic acid was tested in a randomized study involving 32 patients with type 2 diabetes mellitus. Patients received banaba 32 or 48 mg or placebo for 2 weeks.58 Banaba significantly reduced blood sugar levels without any particular side effects.
Increasing the Sensitivity of Adipocytes and Skeletal Muscle Cells to Insulin
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
The leaves of Weigela subsessilis L.H. Bailey contain corosolic acid, ursolic acid, ilekudinol B, and pomolic which induced glucose uptake by L6 myotubes in the absence or presence of insulin in vitro with a maximal activity at 50 μM.194 Ilekudinol A, Ilekudinol B, and ursolic inhibited protein-tyrosine phosphatase 1B activity with IC50 of 29.1, 5.3, and 3.6 μM (RK-682: 4.5 μM), respectively.195 The hypoglycemic properties of corosolic acid have been discussed elsewhere.
Corosolic acid inhibits tumour growth without compromising associating liver partition and portal vein ligation-induced liver regeneration in rats
Published in Annals of Medicine, 2022
Jinwei Zhao, Weiyi Zhao, Hongyue Xu, Wenjing Luan, Xuefei Wang, Yimu Fang, Lu Yu
Corosolic acid (CA), a pentacyclic triterpene compound, is one of the lipophilic triterpene acids extracted from Lagerstroemia speciosa leaves [14,15]. It has been shown to have excellent antitumor-promoting potency in several types of tumours both in vitro and in vivo, and the targets of its antitumor effects include the signal transducer and activator of transcription (STAT)-3, nuclear factor kappa B (NF-κB), and Wnt/β-catenin [16,17]. However, the role of CA in liver tumours affected by the stimulation of liver regeneration remains largely unknown. It is also unclear whether transforming growth factor-beta (TGF-β)/vascular endothelial growth factor (VEGF), and programmed cell death protein (PD)-1/PD ligand 1 (PD-L1) pathways play a pivotal role in CA-induced tumour cell death. The current study aimed to investigate the effect of CA on ALPPS-induced liver regeneration and hepatic tumour progression after ALPPS-induced liver regeneration.
Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats
Published in Drug and Chemical Toxicology, 2022
Thakur Rohit Singh, Devaraj Ezhilarasan
Lagerstroemia speciosa Pers., (Lythraceae) commonly known as Banaba (Pride of India) has been traditionally used to treat various ailments including diabetes and obesity (Stohs et al.2012). The leaves, stems, flowers, fruits, bark and roots of this plant contain a variety of phytocompounds like ellagic acids, glycosides, flavones, triterpenes (corosolic acid), and tannins, etc. (Stohs et al.2012, Tiwary et al.2017). The presence of corosolic acid in leaves of L. speciosa was attributed to beneficial effects (Jayakumar et al.2014, Rohit Singh and Ezhilarasan 2020, Zhang et al.2020). Previous in vivo studies have shown the anti-inflammatory, anti-diarrheal, and anti-gout effects of banaba (Stohs et al.2012). In the context of the liver, banaba petal extract attenuated carbon tetrachloride-induced oxidative stress and hepatotoxicity in mice (Tiwary et al.2017). Our recent in vitro studies have explored the pro-apoptotic and cell cycle arresting potential of ethanolic banaba leaf extract (EBLE) in liver cancer cells (Rohit Singh and Ezhilarasan 2020, Thakur and Devaraj 2020). Therefore, in this study, we investigated the antioxidant and hepatoprotective effect of EBLE against DDS-induced hepatotoxicity in rats.
Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery
Published in Expert Opinion on Drug Discovery, 2021
Hidayat Hussain, Iftikhar Ali, Daijie Wang, Faruck L. Hakkim, Bernhard Westermann, Luay Rashan, Ishtiaq Ahmed, Ivan R. Green
Pentacyclic triterpenes demonstrated interesting biological effects with some rather unique mechanisms of action. For instance, they showed antidiabetic, antitumor, antiviral, analgesic, antiparasitic, anti-inflammatory, antimicrobial, hypolipidemic effects, anti-obesity effects, and ameliorating effects [1–4]. Additionally, some pentacyclic triterpenoids are currently marketed as therapeutic agents and for instance, glycyrrhizic acid and oleanolic acid are registered as drugs for the treatment of various liver diseases. On the other hand, corosolic acid and gymnemic acids are registered as dietary supplements for diabetes while carbenoxolone and asiaticoside are used as drugs to treat gastritis and wound-healing, respectively [1–4]. Moreover, pentacyclic triterpenes are in various phases of clinical trials viz., bevirimat (PA-457), S-0139, and RTA 404 are in phase II clinical trials to treat HIV infection, cerebrovascular diseases, and multiple sclerosis, respectively. Additionally, two oleanolic acid analogs CDDO (phase I) and CDDO-Me (phase II) are in clinical trials in the USA for cancers [1,2].