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Atlas of Autofluorescence in Plant Pharmaceutical Materials
Published in Victoria Vladimirovna Roshchina, Fluorescence of Living Plant Cells for Phytomedicine Preparations, 2020
Victoria Vladimirovna Roshchina
Zhang with coworkers (2018) summarized the structures of 259 compounds isolated from the genus Leonurus, featuring 147 labdane diterpenoids. Anti-inflammation is the major bioactivity discovered so far for the labdane diterpenoids from the genus Leonurus, whose further therapeutic potential still needs study. In addition to the traditional uterine contraction and sedative activity, recently, the cardiovascular protection effect of leonurine has attracted much attention. In addition, neuroprotection, anti-inflammation, anticancer, anti-platelet aggregation, and many other activities have been assigned to various compounds from the genus Leonurus. Among 70 bioactivity references cited, 57% of them concentrated on two alkaloids (leonurine and stachydrine), whereas only 20% were about the 147 diterpenoids. The sedative activity of L. cardiaca is thought to be due to the iridoids components just as in other anti-anxiety herbs. Some formulae of the most active compounds are represented in Figure 3.16.
Plant Species from the Atlantic Forest Biome and Their Bioactive Constituents
Published in Luzia Valentina Modolo, Mary Ann Foglio, Brazilian Medicinal Plants, 2019
Rebeca Previate Medina, Carolina Rabal Biasetto, Lidiane Gaspareto Felippe, Lilian Cherubin Correia, Marília Valli, Afif Felix Monteiro, Alberto José Cavalheiro, Ângela Regina Araújo, Ian Castro-Gamboa, Maysa Furlan, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva
Additional antibacterial compounds were isolated from Stemodia foliosa Benth. (Plantaginaceae), popularly known as “meladinha”' and used in Brazilian folk medicine as bioinsecticide and to treat respiratory infections. The ethanol extract from the aerial parts of S. foliosa, afforded three labdane diterpenoids, 6α-acetoxymanoyl oxide (118), 6α-malonyloxymanoyl oxide (119) and 6α-malonyloxy-n-butylestermanoyl oxide (120) (Figure 9.25), along with the triterpenes betulinic acid and lupeol, and the steroids stigmasterol and sitosterol. The isolated diterpenes were evaluated using a disc diffusion assay against Gram-positive bacteria S. aureus, Bacillus cereus, B. subtilis, B. anthracis, Micrococcus luteus, Mycobacterium smegmatis and M. phlei. Compound 119 exhibited moderate activity against these strains (MIC 7–20 μg mL−1) which might be associated to the reported plant use in traditional medicine to treat respiratory infections (Silva et al., 2008).
Terpenes and Terpenoids
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
William J. Rea, Kalpana D. Patel
Diterpenes emanate from the resins of various coniferous species. Abietic acid derivatives are the principal product of rosin, a resin that comes mainly from pine and has a variety of industrial uses, most of which exacerbate sensitivity in the individual who is chemically sensitive. Labdanes and clerodanes are the “bitter” principle of bark, roots, and stems (from clerodane and horehound).78
Design, biological evaluation, and molecular modelling insights of cupressic acid derivatives as promising anti-inflammatory agents
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Amal F. Soliman, Diaaeldin M. Elimam, Fardous F. El-Senduny, Manal A. Alossaimi, Mubarak Alamri, Fatma M. Abdel Bar
Little has been done on the semi-synthesis and biological evaluation of labdane terpenes obtained from Araucaria heterophylla. Cupressic acid diterpenes (Figure 2), possess a carboxylic acid moiety and a hydroxyl functional group, both of which are amenable to chemical modification and functionalization. In this work, we implemented the approach of rational, yet simple, chemical derivatization to semi-synthesize more potent and/or selective anti-inflammatory lead compounds. Additionally, a docking study has been conducted to explore the possible inhibition of PLA2 by the investigated compounds.