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Tissue Grafting Techniques
Published in Vineet Relhan, Vijay Kumar Garg, Sneha Ghunawat, Khushbu Mahajan, Comprehensive Textbook on Vitiligo, 2020
For attaining success in the surgical procedure, a still and calm patient is a prerequisite. In an anxious patient, 5 mg diazepam can be given the previous night and 2 hours before the procedure. At some centers its customary to give 5–10 mg of diazepam and/or 10 mg of ketobemidone orally 60–90 minutes before the procedure plus 500–1000 mg paracetamol 40–50 minutes before the transplantation [13].
Pharmacokinetic-Pharmacodynamic Correlations of Analgesics
Published in Hartmut Derendorf, Günther Hochhaus, Handbook of Pharmacokinetic/Pharmacodynamic Correlation, 2019
A fixed effect PD model has also been applied to concentration-analgesic effect data from ketobemidone, an opioid structurally related to meperidine and used predominantly in Europe.32 Similar to morphine and meperidine, probit analysis can be used to generate quantal pharmacodynamic data for ketobemidone (Figure 2B). It can also be seen from Table 1 that there is good agreement between the estimate of MEC and the generated Css50 from quantal analysis.
Analgesic effects of dexmedetomidine and remifentanil on periprocedural pain during percutaneous ablation of renal carcinoma
Published in Upsala Journal of Medical Sciences, 2020
Egidijus Semenas, Maria Lönnemark, Pär Dahlman, Michael Hultström, Mats Eriksson
Four patients (8%) experienced postoperative nausea and vomiting, which needed treatment with metoclopramide, ondansetron, betamethasone, or a mixture thereof, during the post-interventional phase. Thirty-five patients (73%) experienced pain (NRS > 0) during the recovery phase. Morphine, usually at low dose (mean: 3.5 mg; median: 1 mg; IQR: 0–7) was administered to 25 of these patients. Ketobemidone at 2 mg was given to 2 of these 35 patients. Paracetamol was given to 18 patients, who had not received paracetamol as premedication. Eleven patients were given clonidine intravenously. Fifteen patients needed mixtures of these analgesic drugs during the recovery phase.