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Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Iodoform is an organo-iodine compound with the formula CHI3 and a tetrahedral molecular geometry. It is a relatively water-insoluble yellow solid powder or crystals with penetrating odor and unctuous feel, that is chemically reactive in free-radical reactions. Since the beginning of the 20th century, iodoform has been commonly used as a healing and antiseptic dressing or powder for wounds and sores, but currently such clinical use is limited, although bismuth iodoform paraffin paste (BIPP) may still be one of the most commonly used packs after middle and external ear surgery (4,7). Iodoform has also been found in dental paste and root canal filling materials in combination with other intracanal medications for its radiopacity. It may also still be used for veterinary purposes. When iodoform decomposes it releases iodine in nascent state (96.7% of iodine) when in contact with secretions, endodontic infections or granulation tissue (1).
The nineteenth century
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
Tincture of iodine was used as an antiseptic in French surgery in 1839 and was employed in treating battle wounds during the US Civil War. Iodoform was first prepared by Georges Simon Serullas (1822). An antiseptic and local anesthetic with a saffron like odor, it was a yellow crystalline substance (triiodomethane) and contained about 97% iodine (Ringer, 1888 pp. 341–4). It was first used in medicine by Bouchardat in 1836 but only came into general use as an ‘iodoform dressing’ in surgery in the late 1870s. Iodoform was particularly useful for syphilitic sores, soft chancres and orchitis. It was employed as a vaginal bolus, in a compound with cocoa-nut fat, in cases of uterine cancer. In high dosage it could have serious side-effects including death. Iodol (tetraiodopyrol) contained 80% iodine and was prescribed in place of iodoform, having a great advantage in being free from smell. Iodol prevented suppuration and was highly useful in syphilis and as a general antiseptic.
Assembly of a Technological Vision for X-Ray Contrast Agents
Published in Christoph de Haën, X-Ray Contrast Agent Technology, 2019
The next stories sketch how iodine became recognized as the X-ray-absorbing element with outstanding potential as constituent of contrast agents. In early February 1896, Maurice Meslans, associate professor in the School of Pharmacy in Nancy, addressed the opacity of chemicals and pharmaceuticals selected on the basis of their chemical constituents (Meslans 1896). He found iodine, even as part of an organic compound, to contribute strongly to the opacity. In particular, he emphasized the extraordinary opacity of iodoform, i.e., CHI3. Iodoform was used topically, intramuscularly, and orally in several pharmaceutical formulations against various infections. A preferred formulation for injection into cold tubercular abscesses and tubercular joint cavities, commercially called JODOFORM-GLYCERIN (Guttstadt 1891), consisted of a 9.1%(w/w)29 fine suspension of iodoform in glycerol (Trendelenburg 1926). Apparently, it was prepared on prescription by pharmacies, Chemische Fabrik auf Actien (vormals E. Schering) in Berlin30, 31 being a major producer and supplier of iodoform.
Effectiveness of iodoform-based filling materials in root canal treatment of deciduous teeth: a systematic review and meta-analysis
Published in Biomaterial Investigations in Dentistry, 2022
Manoelito Ferreira Silva Junior, Leticia Maíra Wambier, Mayara Vitorino Gevert, Ana Cláudia Rodrigues Chibinski
Several iodoform-based filling materials had been used in the studies. Iodoform with calcium hydroxide was present in the commercial brands: Metapex [9,10,19,20] and Vitapex [14–17,27–29] and Maisto-Capurro paste [30]. Iodoform associated with zinc oxide, eugenol and calcium hydroxide was synthesized using all these components [17], without addition of chlorophenol [9], with addition of propolis [36], or as the commercial brand (Endoflas) [11,12,18,19,35]. One study used iodoform, zinc oxide and eugenol (RCFill) [16] and another study used iodoform, zinc oxide eugenol (ZOE), bismuth subcarbonate, resins, barium sulphate, eugenol and excipients (Zical) [21]. Two studies used different versions of the modified Guedes-Pinto paste [37,38], and finally one study used Maisto paste [13].
English Translation of M. Bérard: Tumeur Embryonnaire Du Muscle Strié. [Embryonal Tumor of Striated Muscle]. Lyon Med 1894; 77: 52
Published in Fetal and Pediatric Pathology, 2019
R. Beverly Raney, Christophe Bergeron, David Parham
At that moment, suddenly there was rather abundant bleeding, which was dried up by tamponage with iodoform gauze. The peritoneum, lacerated at one limited point during these maneuvers, was sutured. We very rapidly abraded portions of the lumbosacral muscles without being able to complete the procedure, because the little patient became upset; artificial respiration and injections of ether allowed him to be transported on his bed; he regained consciousness, but death occurred during his journey from the operative suite. Autopsy could not be done.
A painful periumbilical rash
Published in Baylor University Medical Center Proceedings, 2019
Sima Amin, Sheevam Shah, J. Scott Thomas, Katherine Fiala
The umbilicus was surgically explored to rule out a persistent urachus and revealed a 7-cm defect that tunneled down to the fascia. The wound was irrigated with povidone-iodine solution and packed with iodoform gauze. After surgery, she was treated with wound care and a 1-month course of amoxicillin for the actinomyces grown on wound culture broth. The drainage and erosive lesions initially improved; however, 10 months later, the patient is considering magnetic resonance imaging to further evaluate the soft tissue defect and umbilical excision.