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Cinchona officinalis (Cinchona Tree) and Corylus avellana (Common Hazel)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Sawsan A. Oran, Arwa Rasem Althaher, Mohammad S. Mubarak
A published study revealed hyperoside (Peev et al., 2007) in hazelnut leaves and rutin (Yuan et al., 2018; Solar et al., 2009) in kernels and shells. In addition, the hazelnut kernel has been recognized as containing quercetin glucuronide and isorhamnetin-3-O-rutinoside (Pelvan et al., 2018). Besides, eriodictyol was tentatively detected in the hazelnut kernel (Prosperini et al., 2009), taxifolin in the shells (Yuan et al., 2018), and naringin in the shells and skins of hazelnuts (Mattonai et al., 2017), while phloretin 2′-O-glucoside, a dihydrochalcone glucoside, has been found in hazelnut kernels and shells (Jakopic et al., 2011; Yuan et al., 2018). Catechin, epicatechin, and epigallocatechin have been found in hazelnut kernels (Fanali et al., 2018), shells (Yuan et al., 2018), and skins (Monagas et al., 2009), gallocatechin in the skins (Del Rio et al., 2011).
Flavonoids with Preclinical Antidepressant-Like Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Hyperoside is an anthocyanin glycoside in St John’s wort, Drosera rotundifolia, Lamiaceae Stachys, Prunella vulgaris, Rumex acetosella, Cuscuta chinensis, Camptotheca acuminate, birch leaves, various fruits, marigold, and tea. Hyperoside reduces immobility of both rats and mice in the forced swim test.41,42 In cultured mouse neurons that had been exposed to toxic levels of corticosterone, hyperoside protects against cytotoxicity by increasing levels of BDNF and CREB.43 Some of the antidepressant-like effect of hyperoside could be due to such increases.
Natural Products as an Effective Treatment Option for Depression
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Yogesh Anant Kulkarni, Kalyani Himanshu Barve, Ginpreet Kaur
Hyperoside, a common flavonoid found in Hypericum species, was found to have a depressor effect on the central nervous system as well as an antidepressant-like effect partly due to its D2 receptor antagonistic effect.44
In-vitro and in-vivo evaluation and anti-colitis activity of esculetin-loaded nanostructured lipid carrier decorated with DSPE-MPEG2000
Published in Journal of Microencapsulation, 2023
Feng Shi, Wenxiong Yin, Michael Adu-Frimpong, Xiaoxiao Li, Xiaoli Xia, Weigang Sun, Hao Ji, Elmurat Toreniyazov, Wang Qilong, Xia Cao, Jiangnan Yu, Ximing Xu
This procedure was carried out according to Chinese Pharmacopoeia detection conditions. The chromatographic column adopts C18 column (4.6 mm × 250 mm, 5 μm, Shimadzu, Japan), with a mobile phase that consisted of acetonitrile: 0.1% phosphoric acid water (20:80) at 1 ml/min, The detection wavelength was 345 nm with a column temperature of 30 °C (Rehman et al.2015). The in-vitro calibration curve with different gradient concentrations was established by using the standard solution of esculetin (0.05, 0.1, 0.2, 0.5, 1, 2, 5, 10, 25, 50 and 100 μg/mL), wherein the curve was fitted to obtain a linear equation: Y = 75104X–8395.4 (R2=0.9999). The X represents the concentration of esculetin, while Y denotes the peak area of esculetin. At the same time, hyperoside was selected as the internal standard substance with its concentration being 10 μg/mL. The in-vivo standard of different gradient concentrations of esculetin was established in the blank serum of rats (0.05, 0.1, 0.2, 0.5, 1, 2, 5, 10, 25 and 50 μg/mL). The sample processing method was the same as the method stated in 2.8. The curve was fitted to obtain a linear equation: Y = 1.7096X–0.1779 (n = 3, R2=0.9963), where X represents the concentration of esculetin, and Y depicts the ratio of the peak area of esculetin to hyperoside.
Isoliquiritin modulates ferroptosis via NF-κB signaling inhibition and alleviates doxorubicin resistance in breast cancer
Published in Immunopharmacology and Immunotoxicology, 2023
Jiguo Wang, Yang Li, Jing Zhang, Changguo Luo
Resistance to chemotherapy drugs is a dominating obstacle to the treatment of breast cancer in the clinic [42]. Reports have shown that flavonoid glycoside attenuates the resistance to chemotherapy drugs in breast cancer. For instance, hyperoside enhances the sensitivity to paclitaxel in breast cancer cells [43]. Moreover, liquiritin, the homologue of Iso, improves the cisplatin-resistant of gastric cancer cells both in vivo and in vitro [44]. Iso administration induced a concentration-dependent decrease in cell viability and a concentration-dependent increase in the apoptosis rate of both MDA-MB-231/Dox and MCF-7/Dox cells. Therefore, these findings clarified that Iso antagonized Dox‑resistant BC cells to Dox introduction.
Hyperoside ameliorates cerebral ischaemic–reperfusion injury by opening the TRPV4 channel in vivo through the IP3-PKC signalling pathway
Published in Pharmaceutical Biology, 2023
Lei Shi, Chenchen Jiang, Hanghang Xu, Jiangping Wu, Jiajun Lu, Yuxiang He, Xiuyun Yin, Zhuo Chen, Di Cao, Xuebin Shen, Xuefeng Hou, Jun Han
Hyperoside (Hyp) is an active ingredient of the total flavones from Rhododendron (Ericaceae), and it has protective properties against oxidative stress, inflammation and Ca2+ influx (Seki et al. 2017; Xiao et al. 2017). Previous studies have shown that Hyp protects against cerebral ischaemic injury by reducing brain oedema, decreasing infarction size, relaxing cerebrovascular vessels and increasing cerebral blood flow (Bagher and Garland 2014; Wang et al. 2020). Thus, Hyp is presumed to be a potential therapeutic agent for ameliorating the self-repair process following ischaemic stroke. However, the mechanism of Hyp and its effects on cerebral vasodilation following ischaemic have not yet been fully elucidated.