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Lessons to Be Learnt from Ayurveda
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
Prachi Garodia, Sosmitha Girisa, Varsha Rana, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal
Further studies found the regulation of N.F.-κB by the compounds that were involved in inflammatory and other signaling cascades in cancer cells (Banik et al. 2020). Honokiol prevents the progression of different cancers through the decreased expression of anti-apoptotic proteins, affects the mitochondrial-dependent pathways and elevates apoptosis through the modulation of Ca+2 channels and pro-apoptotic proteins. It affects metastatic activity by inhibiting M.M.P.s, P.I.3K./Akt/mT.O.R., epithelial to mesenchymal transition, N.F.-κB, S.T.A.T.3, and Wnt signaling pathways (Banik et al. 2019). The compound zerumbone could cause a decrease in cancer hallmarks such as survival, proliferation, angiogenesis, invasion and metastasis through the modulation of Akt, N.F.-κB, and I.L.-6/J.A.K.2/S.T.A.T.3 pathways (Girisa et al. 2019).
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Magnolol and honokiol from magnolia are potent antioxidants. They inhibit lipid peroxidation in the mitochondria of rat heart and liver with a potency approximately 1,000 times greater than that of α‑tocopherol.4 Both magnolol and honokiol protected cultured rat cerebellar granule cells from the oxidative effects of hydrogen peroxide, glucose deprivation, and glutamatergic excitotoxicity, with honokiol being the more potent of the two.5 Magnolol also showed neuroprotective antioxidant effects in intact animals. Intravenous administration of magnolol to rats attenuated heatstroke‑induced neuronal damage due to increased free radical formation and lipid peroxidation in the brain.6
Antipsoriatic Medicinal Plants
Published in José L. Martinez, Amner Muñoz-Acevedo, Mahendra Rai, Ethnobotany, 2019
José Luis Ríos, Guillermo R. Schinella, Isabel Andújar
Gambogic acid and honokiol were also demonstrated to be effective in vivo. K14-VEGF transgenic mice with moderate psoriasis treated with gambogic acid showed a reduction in the erythema, resolution of the epidermal hyperplasia and acanthosis, decreased parakeratosis with reduced inflammatory infiltrate and reduced vascular hyperplasia and inflammation (evidenced by reduced expression of adhesion molecules such as E-selectin and ICAM-1). In the case of honokiol, it also normalized the psoriatic phenotype in K14-VEGF mice, producing macroscopic and histologic improvement, and dose-dependently decreased TNF-α and IFN-γ levels, this reduction being associated with suppression of p65-NF-κB expression in the ear tissues analyzed. Both gambogic acid and honokiol inhibited angiogenesis and the expression of vascular endothelial growth factor-2 (VEGF2) and p-VEGFR2 and, in the case of honokiol, this inhibition was accompanied by suppression of phosphorylation of extracellular signal–regulated kinase1/2 (ERK1/2), protein kinase B (AKT) and p38 mitogen-activated protein kinase (p38 MAPK). Gambogic acid was tested in a second animal model: a psoriasis-like model of guinea-pig, where improvements in epidermis and dermic could be detected (Wen et al. 2014a).
Comparison of the GPVI inhibitors losartan and honokiol
Published in Platelets, 2020
Marie-Blanche Onselaer, Magdolna Nagy, Chiara Pallini, Jeremy A Pike, Gina Perrella, Lourdes Garcia Quintanilla, Johannes A Eble, Natalie S. Poulter, Johan W.M. Heemskerk, Steve P Watson
Losartan, an angiotensin II receptor antagonist, has been proposed to inhibit clustering but not binding of GPVI to collagen [15,16], leading to inhibition of platelet activation in vitro and reduced platelet accumulation after carotid injury in mice [17–20]. Honokiol is a natural bioactive molecule isolated from Magnolia species, which is used in traditional Chinese medicine. Honokiol is a multifunctional compound with many potential therapeutic properties, including antioxidant, anti-inflammatory, anti-cancer, anti-depressant and anti-neurodegeneration activities [21–23]. Honokiol also has anti-thrombotic effect, and has been shown to bind to GPVI at concentrations that are three orders of magnitude higher than those required for inhibition of platelet aggregation, suggesting an alternative mechanism of inhibition [24,25].In the present study, we have further interrogated the mechanism of action for both inhibitors.
Hyaluronic acid modified daunorubicin plus honokiol cationic liposomes for the treatment of breast cancer along with the elimination vasculogenic mimicry channels
Published in Journal of Drug Targeting, 2018
Rui-Jun Ju, Lan Cheng, Xiao Qiu, Shuang Liu, Xiao-Li Song, Xiao-Ming Peng, Teng Wang, Cui-Qing Li, Xue-Tao Li
Honokiol (HNK) is an active component isolated and purified from the roots, stem bark or seed cone of the Chinese traditional herb Magnolia officinalis. Honokiol exhibits strong antithrombosis, antibacterial and anxiolytic effects [18]. In addition, HNK has been used to inhibit growth and induce apoptosis of various cancer cells [19]. Recent studies have shown that HNK exhibits potent anticancer activities including anti-angiogenesis and inhibition on cancer cell invasion [20]. Daunorubicin is a typical cytotoxic agent, which is widely used in treating a variety of cancers including leukaemia, breast cancer, ovarian cancer and lung carcinoma, as well as several sarcomas [21]. The underlying mechanism of daunorubicin is associated with the intercalation into double-stranded DNA, which leads to the inhibition of the process of duplication and transcription of mRNA as well as DNA damage by the inhibition of topoisomerase II [22]. Recent studies reveal that treatment with daunorubicin may lead to numerous serious side effects [23].
A novel honokiol liposome: formulation, pharmacokinetics, and antitumor studies
Published in Drug Development and Industrial Pharmacy, 2018
Chuchu Zhou, Chenqi Guo, Wenhao Li, Juan Zhao, Qin Yang, Tiantian Tan, Zhuoya Wan, Jianxia Dong, Xu Song, Tao Gong
We also assessed and compared the safety of the three preparations and empty liposome, including HS15-LP-HNK, PEG-LP-HNK, free HNK, empty HS15-LP, and empty PEG-LP. Honokiol has been claimed to exhibit low toxicity in vivo in vast researches. To further verify the toxicity of our preparations, histological analysis was employed. According to the histological analysis results (Figure 7), the vital organs of mice administrated with HS15-LP-HNK, PEG-LP-HNK, free honokiol, empty HS15-LP, and empty PEG-LP were all normal without pathological changes compared with saline group. It indicated the low toxicity of HNK and our formulations, which is in accordance with the body weight record performed in the antitumor experiment.