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Perspectives of Nature-Oriented Pharmacotherapeutics for the Effectual Management of Hemorrhoidal Symptoms
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Taranpreet Kaur Bamrah, Mojabir Hussen Ansari, Debarshi Kar Mahapatra
Ginkgo biloba leaf extract is very useful in the management of acute hemorrhoidal attacks when used in the combination with troxerutin (a flavonoid) and heptaminol (a vasodilator). The anti-inflammatory and venoprotective activity of Ginkgo biloba is highly beneficial in treating hemorrhoids.
Efficacy of tocopherol and pentoxifylline combined therapy for women undergoing assisted reproductive treatment with poor endometrial development: a retrospective cohort study on 143 patients
Published in Human Fertility, 2021
Fabien Krief, Cynthia Simon, Rebecca Goldstein, Laura Prat Ellenberg, Nathalie Ledee
Some previous studies, using tocopherol and PTX to reduce radiation-related fibrosis, showed that a longer treatment yields a better outcome (Delanian, Porcher, Rudant, & Lefaix, 2005), with benefits apparent at 6 months and a maximum efficiency at 18 months (Delanian, Balla-Mekias, & Lefaix, 1999). In our experience, the duration of treatment increases with the severity of the poor endometrial development, and the treatment is continued until the day of embryo transfer (Letur-Könirsch et al., 2002). It is generally agreed that a good treatment tolerance and adherence seems to be essential to avoid non-compliance. PTX, which is known to induce orthostatic hypotension, requires medical supervision. This side effect could be prevented by the use of heptaminol chlorydrate (HEPT-A-MYL®, Sanofi-Aventis, France). Furthermore, a slow dose increase could avoid side effects like headache, vertigo, or hot flushes. Thus, a medical follow-up with measurement of the EV every 3 months should be implemented to evaluate treatment effectiveness, tolerance and compliance.