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Herbal and Supplement Use in Pain Management
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
Mechanism of action: the iridoid glycoside constituents of devil’s claw seem to have an anti-inflammatory effect. Some preliminary research suggests that harpagoside inhibits both the cyclooxygenase (COX) and lipoxygenase inflammatory pathways.11
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Dried roots contain the bitter harpagoside (C24H30O11), the sweet harpagide (C15H24O11), and procumbide (C15H24O11), 0.3% raffinose, 0.6 to 0.8% stachyose, saccharose, glucose, and fructose. The plant extract and harpagide show positive effects on arthritic rats; harpagoside and harpagide are antiinflammatory, harpagoside exhibits analgesic activity.33
Complementary and Alternative Medicine in the Management of Chronic Pain
Published in Gary W. Jay, Clinician’s Guide to Chronic Headache and Facial Pain, 2016
Several meta-analyses have reported on the efficacy of diet and herbs in relieving chronic pain (37,38). Harpagoside procumbens (devil’s claw) has been studied in two dosage strengths, 50 mg and 100 mg. Over 500 patients have been studied. Compared with placebo, both dosage strengths clinically and significantly reduced pain. The Cochrane Review concluded that there is strong evidence that harpagoside reduced pain more than placebo in patients with acute episodes of nonspecific low back pain (37). It appears to have similar efficacy to rofecoxib 12.5 mg daily. Two trials including 261 patients have compared the analgesic effects of Salix alba (white willow bark) in doses of 120 mg daily and 240 mg daily. Salix alba’s active ingredient is salicin, a derivative of salicylic acid, and is chemically related to aspirin. There is moderate evidence that it reduced pain more than placebo in the treatment of acute episodes of nonspecific low back pain and that it is similar in effectiveness to rofecoxib 12.5 mg daily. There is limited evidence that the cream is effective (37). There is not enough evidence to comment on the analgesic efficacy of other herbs or homeopathy.
Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients
Published in Journal of Dietary Supplements, 2019
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M. Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X. Comas Figuerola, María E. Aguilar Hernández
Clinical trials have shown that CS and GS are effective and safe drugs for pain control and functional improvement in patients with mild to moderate OA of the knee (Michel et al., 2005; Kahan, Uebelhart, De Vathaire, Delmas, & Reginster, 2009; Hochberg, 2010; Lee, Woo, Choi, Ji, & Song, 2010). In addition, the combination of these two compounds could have a positive synergistic effect on the various affected structures of the joint (Canapp, McLaughlin, Hoskinson, Roush, & Butine, 1999; McCarty, Russell, & Seed, 2000; Tat et al., 2007; Calamia et al., 2010). In the present study, CS and GS have been linked with other components as a food supplement (Artipotect®). Other ingredients include hydrolyzed collagen and devil's claw (Harpagophytum procumbens) and bamboo (Bambusa arundinasa) extracts. Hydrolyzed collagen has been shown to improve joint function and be effective in managing OA-associated symptoms (Schauss, Stenehjem, Park, Endres, & Clewell, 2012). Devil's claw contains harpagoside, a monoterpenoid specific of devil's claw and responsible for the anti-inflammatory activity attributed to this plant. Several studies have shown the beneficial effects of harpagoside in OA and other inflammatory diseases (Chrubasik, Conradt, & Roufogalis, 2004; Oltean et al., 2014). Harpagoside suppresses IL-6 expression in primary human OA chondrocytes, leading to a significant anti-inflammatory effect (Haseeb, Ansari, & Haqqi, 2017). Bamboo extract is a rich source of organic silica (>70%) and traditionally has been considered useful in strengthening the musculoskeletal system.
Effects and mechanisms of natural plant active compounds for the treatment of osteoclast-mediated bone destructive diseases
Published in Journal of Drug Targeting, 2022
Qiang Xu, Zhiyou Cao, JiaQiang Xu, Min Dai, Bin Zhang, Qi Lai, Xuqiang Liu
Harpagoside, a glycoside isolated from Harpagophytum procumbens, inhibits RANKL-induced osteoclastogenesis in vitro, and suppresses inflammation-induced bone loss in mice by suppressing ERK, JNK, and Syk-Btk-PLCγ2-Ca2+ signalling, and the activation of c-Fos and NFATc1 [94]. Additionally, it inhibits LPS-induced bone loss in inflammatory osteoporosis. However, it does not prevent ovariectomy-mediated bone erosion in post-menopausal osteoporosis. These results suggest that harpagoside is useful against inflammation-related bone disorders, but not against osteoporosis induced by hormonal abnormalities.
Harpagoside-induced anaphylactic reaction in an IgE-independent manner both in vitro and in vivo
Published in Immunopharmacology and Immunotoxicology, 2018
Delu Che, Jiao Cao, Rui Liu, Jue Wang, Yajing Hou, Tao Zhang, Nan Wang
Harpagoside (HAR), a derivative of catalpol, is an iridoid glycoside from Scrophularia ningpoensis1. HAR was shown to have pharmacological activities in various diseases, such as inflammation2,3, ischemia1 and osteoarthritis, among others4,5. While HAR is widely used worldwide, its allergic effects remain unclear.