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Lessons to Be Learnt from Ayurveda
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
Prachi Garodia, Sosmitha Girisa, Varsha Rana, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal
The herb Gymnema sylvestre has gained importance, as chewing its leaves can reduce the sensation of sweet taste due to which it is known as gurmār or “sugar-destroyer” (Power 1904). An extract of Gymnema sylvestre leaves (400 mg/day) was administered to 22 type 2 diabetic patients for 18–20 months, in addition to conventional oral drugs. The patients showed a significant decrease in blood glucose, glycosylated hemoglobin and glycosylated plasma proteins. The conventional drugs could also be withdrawn. Five patients on the extract treatment were able to maintain their glucose homeostasis and discontinued the conventional drugs, indicating regeneration of beta cells in them, as evidenced by increased insulin levels (Baskaran et al. 1990).
Taste Modifiers and Sweet Proteins
Published in Robert H. Cagan, Neural Mechanisms in Taste, 2020
Extracts from the plant Gymnema sylvestris R. Br. (Asclepiadaceae), which is native to India, have the particular property of reducing sweetness sensitivity. This effect was first mentioned in a communication to the Linnaean Society of London in 1847.35
Nutraceutical Herbs and Insulin Resistance
Published in Robert E.C. Wildman, Richard S. Bruno, Handbook of Nutraceuticals and Functional Foods, 2019
Giuseppe Derosa, Pamela Maffioli
Gymnema sylvestre helps to promote weight loss through its ability to reduce the desire for sweets, and also controls blood glucose levels. Chewing the leaves, rinsing the mouth with watery extracts, or applying an extract topically on the tongue selectively inhibit the feeling of sweetness. Some studies have suggested that gymnemic acid binds to the receptor located on the taste buds of the tongue and prevents their activation by the sugar molecules. Gymnema sylvestre also suppresses the absorption of sugars, presumably by blocking the sucrose receptors through one of its component, the peptide gurmarin.42,43 It would seem, moreover, that not only does this plant block the receptors at the level of the mouth, it also acts, with the same inhibitory activity, on the sodium-dependent glucose transporters expressed at high concentrations on the intestinal cell brush.44
Radio-protective efficacy of Gymnema sylvestre on Pangasius sutchi against gamma (60Co) irradiation
Published in International Journal of Radiation Biology, 2022
Pamela Sinha, Kantha Devi Arunachalam, Santhosh Kumar Nagarajan, Thirumurthy Madhavan, Arumugam R. Jayakumar, Mohamed Saiyad Musthafa
All chemicals and reagents (analytical grade) used for cell culture and assays were purchased from Sigma Aldrich, Bangalore, India. Gymnemagenin the bioactive compound from Natural remedies Pvt, Ltd. Bengaluru, Karnataka, India. The Gymnema sylvestre leaves were obtained from the Herbal Garden, Tamil University, Thanjavur, Tamil Nadu.