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Saussurea costus (Kust) and Senna alexandrina (Senna)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Amita Dubey, Soni Gupta, Mushfa Khatoon, Anil Kumar Gupta
The structure–activity relationship of dehydrocostus lactone and mokko lactone from costus and other guainolides were tested for the inhibition activity of the killing potential of CTL and stimulation of intercellular adhesion molecule-1 (ICAM-1). It was reported that the guaianolides, having α-methylene-γ-lactone moiety, showed strong inhibitory action on the killing potential of CTL and the ICAM-1 stimulation (Yuuya et al., 1999).
Brazilian Bryophytes and Pteridophytes as Rich Sources of Medicinal Compounds
Published in Luzia Valentina Modolo, Mary Ann Foglio, Brazilian Medicinal Plants, 2019
Adaíses Simone Maciel-Silva, Lucas Vieira Lima
Several eudesmanolides, germacranolides, and guaianolides isolated from liverworts exhibit cytotoxic activity against KB nasopharyngeal and P-388 lymphocytic leukemia cells. Some Marchantia species produce marchantins A, B, D, perrottetin F, and paleatin B, which show DNA polymerase β inhibitory activity (IC50 range 14.4–97.5 µM), cytotoxicity against KB cells (IC50 range 3.7–20 µM), and anti-HIV-1 activity (IC50 range 5.3–23.7 mg/cm3) (Asakawa et al., 2008, 2009).
Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention
Published in Expert Opinion on Drug Discovery, 2022
Israa A. Cheikh, Chirine El-Baba, Ali Youssef, Najat A. Saliba, Akram Ghantous, Nadine Darwiche
The antitumor activities of the guaianolide and germacranolide subfamilies of SLs seem to be the most frequently reported, compared to other SL subfamilies (Lesson 1, Figure 3) (Supplementary Figure 1). The natural abundance of these subfamilies could be a possible contributing factor [226]. However, structure-activity relationships demonstrated that the pharmacophores of the guaianolide and germacranolide SLs might justify their extensive anticancer investigations in cell and animal models. For example, the 5,7,5-ring structure of guaianolide SLs, including micheliolide, arglabin, and dehydrocostuslactone, was particularly important to target AML and progenitor cells [57]. Reducing the 11,13-double bond of micheliolide abolished its antileukemic activity, which highlights the antitumor selectivity of this chemical moiety [72]. Aside from the α-methylene-γ-lactone common to most SLs, the electron affinity, shape index, lipophilicity and polarity of the germacranolide parthenolide were paramount to induce antitumor effects [84]. [7]. Future detailed structure-activity relationships are warranted for the other germacranolide SLs, particularly costunolide and deoxyelephantopin.
Pulicaria crispa mitigates nephrotoxicity induced by carbon tetrachloride in rats via regulation oxidative, inflammatory, tubular and glomerular indices
Published in Biomarkers, 2022
Wessam M. Aziz, Manal A. Hamed, Howaida I. Abd-Alla, Samia A. Ahmed
The anti-inflammatory properties of P. crispa could be attributed to the synergistic effect of fatty acids present as a mixture of α-linolenic, linoleic, capric, lauric, linoleic, myristic, oleic, palmitic and stearic acid (Gopinath et al. 2011). An increased dietary intake of α-linolenic acid has reported to reduce the prevalence of chronic kidney disease. A protection and a lower risk of developing renal insufficiency were associated with the higher plasma α-linolenic acid. This protection could be slightly attributed to the presence of sterols and unsaturated fatty acids in high content of P. crispa. Sesquiterpene lactones present in P. crispa extract also have an important role as anti-inflammatory agents (Vargas et al. 2018). Treatment with guaianolide sesquiterpene lactone is currently under clinical trial as anti-cancer agent beside its role for protecting the kidneys against proteinuria, renal failure, histopathological injury, and inflammation in mice (Liu et al. 2019).
The Anticancer Effect of Inula viscosa Methanol Extract by miRNAs’ Re-regulation: An in vitro Study on Human Malignant Melanoma Cells
Published in Nutrition and Cancer, 2022
Dilara Kamer Colak, Unal Egeli, Isil Ezgi Eryilmaz, Onder Aybastier, Hulusi Malyer, Gulsah Cecener, Berrin Tunca
Turkey’s natural resources offer scientists a comprehensive catalog for research on new therapeutic agents in cancer therapy. One of these, Inula viscosa (L.) Aiton (IV, “sticky fleabane”, “yapışkan andız otu” in Turkish) is a perennial herb that belongs to the genus Inula and the family Asteraceae. It has approximately a hundred species worldwide and is represented by twenty-seven species, including endemics on Turkey’s geographic boundaries (11). In addition to being consumed as a tea, IV has been used in traditional medicine to treat many diseases such as diabetes, hypertension, bronchitis, tuberculosis, wounds, skin diseases, etc. (12–18). Studies on IV showed that it has consisted of many pharmacologically active compounds, including terpenes, flavonoids, anthranilic acids, lactones, guaianolides, azulenes, costic acid, and essential oils that enable the herb to have a large number of biological activities (19). The presence of antiproliferative, cytotoxic, and anticancer effects due to these components revealed the necessity of IV to be considered as research material for cancer therapy. A few studies in the literature investigate the anticancer effect of IV from different geographical regions in some cancer types (20–27). The results of these studies may vary depending on the cells given and the solvent in which the extract is prepared. Besides, no study evaluated any IV extracts’ effects on metastatic MM, except two of IV’s components (24).