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Nanoparticles of Marine Origin and Their Potential Applications
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Fatemeh Sedaghat, Morteza Yousefzadi, Reza Sheikhakbari-Mehr
There has been a convergence in recent years between biological-based technologies, green chemistry, and nanotechnology. This convergence aims to create new materials and production processes which reduce or eliminate the use of dangerous substances (Fawcett et al., 2017). Due to their unique particle size and shape dependence and their physical, chemical, and biological properties, biologically synthesized nanoparticles are of great interest in the field of biology and medicine. Microorganisms including bacteria, fungi, and algae have been suggested as possible environmentally friendly nano-factories for metal nanoparticle synthesis [Daniel and Astruc, 2004; Manivasagan and Kim, 2015].
Phytoconstituent-Loaded Nanomedicines for Arthritis Management
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Syed Salman Ali, Snigdha Bhardwaj, Najam Ali Khan, Syed Sarim Imam, Chandra Kala
Green synthesis refers the process which uses natural source agents (plant, bacteria, fungi, etc.). As well, all know that plants are sustainable resources in nature and hence may be explored in the green synthesis of nanoparticles and other nanosystems along with these factors like wide distribution, easy availability and reproducibility make them a better candidate for nanomedicines. The green chemistry is an alternative approach to formulate biocompatible nanoparticles by a chemical process and represents the anchor between two emerging specializations such as material science and biotechnology (Nanobiotechnology). Green synthesis is the method of synthesizing nanoparticles from herbal resources. Several metallic nanoparticles using herbal bioactives have been synthesized by this process (Table 8.2). The metal nanoparticle-herb combination may show better efficacy against different inflammatory conditions.
Green Nanoparticles
Published in Richard L. K. Glover, Daniel Nyanganyura, Rofhiwa Bridget Mulaudzi, Maluta Steven Mufamadi, Green Synthesis in Nanomedicine and Human Health, 2021
Razia Z. Adam, Enas Ismail, Fanelwa Ajayi, Widadh Klein, Germana Lyimo, Ahmed A. Hussein
Green nanotechnology is a branch of green technology that utilizes and incorporates the main principles and concepts of green chemistry and green engineering in the design and development of green nanomaterial production methods for application in various areas (Verma et al., 2019). This has afforded researchers the opportunity to render nanotechnology less toxic throughout its life cycle and make safer and more sustainable. Green nanotechnology mainly targets reduction of waste gas emission, decreased consumption of non-renewable raw materials and increased energy efficiency. The green synthesis methods provide alternative approaches to chemical and physical methods. The green approach avoids the use of harmful and toxic chemicals as well as the need for expensive chemicals, affording an environment-friendly method of nanoparticles synthesis.
Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration
Published in Pharmaceutical Development and Technology, 2022
Jafar Akbari, Majid Saeedi, Fatemeh Ahmadi, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei, Sadra Yaddollahi, Seyyed Sohrab Rostamkalaei, Kofi Asare-Addo, Ali Nokhodchi
Pharmaceutical production is the supreme solvent-intensive and the least efficient of all chemical industries causing waste prepared per unit of produce (Rajagopal R 2014). To circumvent this challenge, ‘green’ methods have been developed as a way of decreasing the ecological influence the pharmaceutical industry has. Over the past few decades, the field of green technology, also called sustainable chemistry has expanded. Many independent activities have been carried out in research, science, and industry (Sanjay 2019). Green chemistry has a good plan, production, and use of chemical harvests and facilities which are environmentally safe. Nevertheless, while green chemistry works mainly on technical issues and engineering, sustainable chemistry includes all life cycle phases. Therefore, the physiological lipid component in the fabrication process of SLNs and NLCs makes this drug delivery system one of the most favorable delivery systems. The goal of this review is thus to explicitly describe and highlight the two kinds of novel and simple scaled-up SLN and NLC with their accompanying recent developments, limitation and toxicities, formulation optimization and approaches for the manufacturing of lipid nanoparticles, lyophilization, and pharmaceutical application. This review also presents the research studies reported on the various technique of production and their essential outcomes.
Machine learning techniques applied to the drug design and discovery of new antivirals: a brief look over the past decade
Published in Expert Opinion on Drug Discovery, 2021
Mateus Sá Magalhães Serafim, Valtair Severino dos Santos Júnior, Jadson Castro Gertrudes, Vinícius Gonçalves Maltarollo, Kathia Maria Honorio
Several applications of ML in drug design and discovery can be found in the literature. A recent topic of great interest is the prediction and optimization of conditions for the organic synthesis of drug candidates, as well as the assessment of the synthetic accessibility of potential molecular modifications in the lead compounds to obtain them with high yield and purity [89–91]. This application can directly affect the value of the process since the difficulty of adapting synthetic methodologies from the academic to the industrial scale can weigh on the final cost of medication in the market [92]. It is worth mentioning that the principles of green chemistry must be applied to the development of more sustainable as well as shorter synthetic steps for application in industrial processes, reducing risks and residues [93]. Therefore, these variables must be also considered in machine learning approaches related to medicinal chemistry.
Prolonged inhibitory effects against planktonic growth, adherence, and biofilm formation of pathogens causing ventilator-associated pneumonia using a novel polyamide/silver nanoparticle composite-coated endotracheal tube
Published in Biofouling, 2020
Sakkarin Lethongkam, Chalongrat Daengngam, Chittreeya Tansakul, Ratchaneewan Siri, Apisit Chumpraman, Manthana Phengmak, Supayang P. Voravuthikunchai
In global attempts to reduce generated harmful chemical waste, green chemistry is attractive in the science and medical fields. A promising water-based technique to produce an AgNP-polymer composite, by reducing Ag ions with gallic acid and loading into polyvinyl alcohol hydrogel has been reported (Loo et al. 2014). Previous work reported green-synthesis of AgNPs using an Eucalyptus citriodora leaf extract exhibited excellent antimicrobial activity (Paosen et al. 2017) with no cytotoxic effects on human lung epithelial cells (Wintachai et al. 2019) or human red blood cells (Paosen et al. 2019). These AgNPs are highly compatible with a hydrophilic polymer matrix, allowing a water-processable technique to effectively incorporate the nanoparticles into polyelectrolyte multilayered film, which form an antibacterial biofilm layer on the ETT surface (Daengngam et al. 2019). However, these highly hydrophilic polymer matrices may encounter a high level of water absorption during use, which would result in degraded mechanical stability and accelerated silver release.