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Autoimmune Diseases and a Multidisciplinary Approach to Cancer
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
There has been a range of research studies documenting the frequency of CAM applications by patients with multiple sclerosis, and the variety of prevalence is absolutely wide, at around 33 to 70%. A number of patients with multiple sclerosis utilised complementary and alternative medicinal approaches and documented benefits from the frequently utilised treatment modalities, which include antioxidants and ω-3 fatty acids. Moreover, to the recognised benefit, the causes of using complementary and alternative medicinal approaches include the wish to improve general health, alleviate psychological and physical symptoms, and inculcate holistic health approaches. Extracts of Ginkgo biloba have a range of pharmacological activities that suggest they may increase cognitive performance and change neural functions. Cognitive disablement can be a significant cause of disability and morbidity and can have an impact on around 40 to 50% of patients with multiple sclerosis. Ginkgo biloba has been advised to make cognitive performance better in Alzheimer's disease, as observed in clinical experiments and a number of other research (Yadav et al., 2010) (Figure 11.5).
Alertness
Published in Charles Theisler, Adjuvant Medical Care, 2023
Ginkgo and Ginseng: A combination of ginkgo biloba and ginseng (600 mg) improved both memory and concentration. In one study, a single dose of ginkgo biloba at 9 AM improved participant’s concentration and speed and the effects were sustained all day. Ginseng was also shown to improve participant’s memory.5
Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, Sarwar Beg
Ginkgo biloba L. is the herb most renowned for its capacity to improve circulation systematically. BP is reduced and the aggregation of platelets is inhibited. Ginkgotides are the main chemical constituent of Ginkgo biloba and are a relevant antioxidant, with neuro-protective, and cholinergic activities in AD management. Scientific studies showed its promise on cognition-enhancement, if used during the early stage of the Alzheimer’s disease. Extract of Ginkgo biloba showed therapeutic benefits in similar, too prescribed medicines like Donepezil or Tactrine with minimally unwanted side effect in the controlled clinical trials of a control and placebo groups (Elias et al., 2010).
Evidence for Complementary and Alternative Therapies to Treat Glaucoma
Published in Seminars in Ophthalmology, 2023
Catherine M. Marando, Teresa C. Chen
Ginkgo biloba extract has neuroprotective and antioxidant properties25 and can improve ocular blood flow.24 Its adverse side effect profile is limited,26 and therefore use of Ginkgo biloba extract is generally well-tolerated. There are case reports of patients developing blood dyscrasias following use of Ginkgo biloba extract, however randomized controlled trials have not shown any changes in the coagulation cascade with Ginkgo biloba extract use.27 Other isolated reports have described cardiac arrythmia following Ginkgo biloba extract use, however this has not been borne out in clinical trials. There is conflicting literature on whether Gingko biloba affects cytochrome function,28,29 however this is another important consideration as its use may potentiate or diminish the effects of other prescription medications. Notably, more than 90% of publications are related to the beneficial effects of Ginkgo biloba extract, and unfortunately less has been reported about its toxicity profile.30
Ginkgo biloba extract 761 reduces vascular permeability of the ovary and improves the symptom of ovarian hyperstimulation syndrome in a rat model
Published in Gynecological Endocrinology, 2022
Jie Zhang, Jie Huang, Xinhuan He, Ning Li, Yu Miao, Beiqing Li, Xiaoguang Shao, Ningning Wang
Ginkgo biloba extract, the dried leaf extract of Ginkgo ginkgo species Ginkgo with the main component flavonoids and terpene lactones, has a variety of health benefits. Ginkgo biloba extract is recognized as a strong antioxidant that can eliminate excess free radicals in the body and prevent lipid peroxidation. It has shown high efficacy and no significant side effects in clinical application. In the early 1960s, extract of Ginkgo biloba has been applied in some countries for the treatment of cerebrovascular diseases and neurological diseases. In addition, it has been considered to have immune-boosting, anti-aging effects and be beneficial for neurodegenerative disorders [18]. The study of Zhang et al. [8] has found that EGb can protect rat aortic endothelial cells from lysophosphatidylcholine by inhibiting the expression of VEGF protein and VEGF mRNA. However, the role and mechanism of EGb in OHSS have not been studied so far. Here, we suggested that EGb could decrease vascular permeability in the OHSS rat model by inhibiting VEGF expression, which may contribute to the prevention and treatment of OHSS. Moreover, the therapeutic medication was more significant than prophylactic medication, providing a theoretical basis for the clinical application of EGb in the treatment of OHSS. As a descriptive study, there are several limitations, especially lacking of evidence from animals with specific gene knockout or in vitro evidence to clarify whether changes in VEGF expression actually mediate the effect of EGb on OHSS or are concomitant, which will be verified next.
Advances in pharmacotherapy of vestibular and ocular motor disorders
Published in Expert Opinion on Pharmacotherapy, 2019
Andreas Zwergal, Michael Strupp, Thomas Brandt
Dizziness is a common accompanying feature in patients with dementia. Prevalence rates between 14.2% and 77.5% for dizziness have been described in elderly patients with different dementia syndromes [66]. Potential explanations for this observation may be an altered processing of multisensory information, a changed perception of the environment, or a higher prevalence of vestibular deficits in patients with dementia [67,68]. A meta-analysis of five prospective, controlled treatment trials, which examined the effects of Ginkgo biloba extract EGb 761 versus placebo on cognitive impairments in a total of 1.972 patients with dementia, indicated a significant reduction of dizziness – measured by an 11-point box scale – after at least 20 weeks of EGb 761 treatment relative to placebo [66].