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Optical Methods for Diabetic Foot Ulcer Screening
Published in Andrey V. Dunaev, Valery V. Tuchin, Biomedical Photonics for Diabetes Research, 2023
Robert Bartlett, Gennadi Saiko, Alexandre Yu. Douplik
The ICG dye is administered intravenously and has a good safety profile. The liver quickly clears it with a half-life of about 3–4 minutes. Liver clearance is important as patients with advanced diabetes are prone to renal impairment, which is frequently a contraindication for those agents dependent on renal clearance. One in 42,000 cases of ICG use may experience minor side effects such as hot flushes, hypotension, tachycardia, dyspnea, and urticaria. The frequencies of mild, moderate, and severe side effects were only 0.15%, 0.2%, and 0.05%. For the competitor substance fluorescein, the proportion of people with side effects is 4.8% [40].
CSF Leaks
Published in John C Watkinson, Raymond W Clarke, Louise Jayne Clark, Adam J Donne, R James A England, Hisham M Mehanna, Gerald William McGarry, Sean Carrie, Basic Sciences Endocrine Surgery Rhinology, 2018
The routine use of lumbar drains in elective CSF leak repair is controversial. Our practice is to use one when intrathecal fluorescein has been employed. The drain is placed at the time of initial lumbar puncture and then ‘closed’ and re-opened immediately prior to repair. Lumbar drains can be associated with important complications and their use requires specialist nursing management. In our hospital, patients with lumbar drains are managed on the neurosurgical floor.
Diabetic retinopathy
Published in Moshe Hod, Lois G. Jovanovic, Gian Carlo Di Renzo, Alberto de Leiva, Oded Langer, Textbook of Diabetes and Pregnancy, 2018
Fluorescein angiography is a sensitive tool to assess the extent of capillary nonperfusion and early neovascularization and may aid in guiding treatment of macular edema, although ophthalmoscopic examination is satisfying in most of the cases for the diagnosis of proliferative retinopathy. In addition, although detrimental effects of fluorescein dye on the fetus have not been documented,177 fluorescein does cross the placenta into the fetal circulation. Thus, fluorescein angiography during pregnancy is generally not indicated.
Fluorescein sodium-guided resection of a cerebellar lymphoma: case report and literature review
Published in British Journal of Neurosurgery, 2023
Andrea Franzini, Edvin Zekaj, Alberto Bona, Andrea Ciuffi, Mauro Porta, Domenico Servello
The main disadvantage when approaching a PNCSL in the posterior fossa by open surgery is that this tumor may present indistinguishably from the normal cerebellar parenchyma, thus forcing the surgeon to identify pathological tissue exclusively by relying on image-guided neuronavigation, intra-operative sonography, and time-consuming frozen section biopsy. To overcome this problem, intraoperative fluorescein (FL) can be adopted. FL is a fluorescent tracer that accumulates in cerebral areas where the blood-brain barrier is damaged and permeable, similar to the process of gadolinium enhancement on MRI.7 Therefore, the use of FL intraoperatively allows for rapid identification of tissue that corresponds to the contrast-enhancing region on brain MRI.7,8 Although FL-guided surgery has been well described for the surgical removal of high-grade gliomas (HGG), it has been only rarely reported for PCNSL surgery.8–10 In this paper, we detail the case of a patient harboring a lesion that was not radiologically univocal in the cerebellum, which was removed by a FL-guided technique, and shown to be a PCNSL. Intra-operative images and, for the first time, a video documentation are is presented (video 1).
Long-term Surgical Outcomes in Patients of Centurion Syndrome: A Mystic Etiology of Epiphora in Young
Published in Seminars in Ophthalmology, 2023
Manpreet Singh, Manpreet Kaur, Aditi Mehta, Manjula Sharma, Pankaj Gupta
Demographic details of all patients were recorded. Age at presentation, the onset of symptoms, previous diagnosis, and treatment were noted in detail. Detailed ophthalmic examination, horizontal palpebral fissure length, and Hertel’s exophthalmometry were performed for each patient (both eyes). The subjective severity of epiphora was evaluated using the Munk score.9 Objectively, the fluorescein dye disappearance test was performed, and the pre and postoperative time of the dye disappearance was noted. Lacrimal irrigation was performed via the superior punctum in all patients to rule out obstruction of the lacrimal drainage system. No radiological evaluation of the patients was performed in our patients. We included and analyzed the symptomatic patients who underwent unilateral or bilateral medial canthal tendon release ± punctoplasty (in cases having punctum stenosis) ± lower eyelid retractor plication (in cases having punctum ectropion).
Association of Dry Eye with Laryngopharyngeal Reflux in Clinical Practice
Published in Current Eye Research, 2022
S. Bonini, M. Labetoulle, E. Messmer, P. Aragona, J. M. Benitez Castillo, G. Ciprandi, V. Damiani, M. Irkec, C. Baudouin, M. Rolando
The current study had some limitations, including the retrospective design and the lack of a documented LPR diagnosis. However, RSI is an excellent tool to suspect LPR.49 Moreover, the comparison group included patients with ocular disorders, so they cannot be considered ideal controls, such as healthy subjects. However, the present non-dry eye group included patients with refractive problems, age- and sex-matched, and recruited in everyday practice; thus, the comparison could be legitimate. It has to be highlighted that there was a prevalence of females, it can attribute to a confounding effect, namely dry eye disease is more likely to affect the female sex. In addition, fluorescein BUT was used instead of non-invasive procedures as it is routinely employed in the clinical practice of the participant centers.