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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Hericium erinaceus also exhibits potent anti-inflammatory effects in vivo. In rats subjected to experimental cerebral ischemia, the herb exerted an anti-inflammatory, neuroprotective effect. The highest dose of lion’s mane extract reduced the area of brain infarct by 44% and reduced tissue levels of the inflammatory cytokines, TNF-α, IL1β, and IL-6. Treatment also suppressed reactive nitrogen species and downregulated inducible NO synthase. Similar effects were seen with the purified phytochemical from the mushroom erinacine A.9
Acute and developmental toxicity assessment of erincine A-enriched Hericium erinaceus mycelia in Sprague–Dawley rats
Published in Drug and Chemical Toxicology, 2018
I-Chen Li, Wan-Ping Chen, Yen-Po Chen, Li-Ya Lee, Yueh-Ting Tsai, Chin-Chu Chen
Hericium erinaceus is an ideal culinary-medicinal mushroom and has recently attracted considerable attention for its positive effects on brain and nerve health by inducing NGF from its bioactive ingredient, erinacine A. This natural inducer of NGF synthesis with a low-molecular weight not only demonstrated its efficacy in several mouse models of age-associated neurological disorders but also achieved such effectiveness via oral delivery (Lee et al. 2014, Kuo et al. 2016, Tsai-Teng et al. 2016). Moreover, EAHE mycelia products have successfully launched onto the market, so there is a high likelihood that these may be used by pregnant women intentionally or unintentionally. Hence, there is an urgent need to acquire more data regarding the safety of their use during pregnancy.
Nanocarriers-loaded with natural actives as newer therapeutic interventions for treatment of hepatocellular carcinoma
Published in Expert Opinion on Drug Delivery, 2021
Mahfoozur Rahman, Waleed H Almalki, Majed Alrobaian, Jawed Iqbal, Saad Alghamdi, Khalid S Alharbi, Nabil K Alruwaili, Abdul Hafeez, Adil Shaharyar, Tanuja Singh, Mohammad Waris, Vikas Kumar, Sarwar Beg
Erinacine is extracted from the mushroom Hericium erinaceus is known for its anticancer action in humans [52]. The experimental studies have indicated that P13 K, Akt, and GSK-3 β genes are upregulated in the HCC tissues which decreases the mitochondrial membrane potential, leading eventually to an increase in the intracellular mitochondrial calcium ion concentration. This further attenuates the release of cyt-C in mitochondria result in cell apoptosis in a dose-dependent manner [52]. Therefore, the above results conclude that erinacine MPTP facilitates the effective release of cyt-C, inhibited cell proliferation, migration, invasion, and apoptosis by inactivating the PI3K/Akt/GSK-3β signaling pathway and minimizes the progression of HCC [52].