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A Comparative Study of Organic Pollutants in Seawater, Sediments, and Oyster Tissues at Hab River Delta, Balochistan Coast, Pakistan
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Sadar Aslam, Malik Wajid Hussain Chan, Grzegorz Boczkaj, Ghazala Siddiqui
The preliminary chemical profiling by GC-MS of seawater and sediments samples from the Hab River Delta revealed the presence of the following seven major groups based on their chemical structure to commonly known classes of compounds: Alkanes (decane, undecane, tetradecane, pentadecane, heptadecane, octadecane, nonadecane, heneicosane, tricosane)Alkenes (decylbenzene, 1-octadecene and 2E)-3,7,11,15-Tetramethyl-2- hexadecene)Ketones (benzophenone)Other organic pollutants (dibenzyl ether)Aromatic hydrocarbons (1,2,3-trimethyIbenzene, indane, 1,4-diethylbenzene, octylbenzene, m-terphenyl; p-terphenyl;3-methylbiphenyl)Cycloalkanes (trans-decalin, octylcyclohexane)Polycyclic aromatic hydrocarbons (PAHs; 2-naphthalenol; 1-phenylnaphthalene; 1-methylanthracene; 3,6-dimethylphenanthrene; anthracene; fluoranthene; pyrene; phenanthrene;9,10-dimethylanthracene; Table 10.1).
Innovative Delivery Systems for Andrographolide Delivery
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
A. C. Santos, J. A. D. Sequeira, F. Veiga, A. Figueiras, A. J. Ribeiro
As already stated, AG is the principal bioactive component responsible for most of the therapeutic properties of Andrographis paniculate (Burm. f.) Nees (Acanthaceae) (Pan et al., 2014, Pawar et al., 2016). Structurally, AG consists of a diterpene containing a γ-lactone ring linked to a decalin ring system through an unsaturated C2 moiety (Tang and Eisenbrandt, 1992), as can be seen in Figure 12.1. Its chemical name is (3-[2-{decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-ethylene-1 naphthalenyl} ethylidene] dihydro-4-hydroxy,2(3H)-furanone), and it has a molecular weight of 350.46 g/mol (Pawar et al., 2016).
Foveal Displacement following Temporal Inverted Internal Limiting Membrane Technique for Full Thickness Macular Holes: 12 Months Results
Published in Current Eye Research, 2021
Sami Yilmaz, Aysegul Mavi Yildiz, Remzi Avci
PPV was performed by two experienced vitreoretinal surgeon (R.A., S.Y.) using 23-gauge vitrectomy system DORC (Dutch Ophtalmic Research Center, Zuidland, the Netherlands) and Zeiss microscope with EIBOS 2 (Haag Strei, Mason, OH, USA) attachment for non-contact fundus viewing. Standart small-incision phacoemulsification (Alcon Infiniti Vision System with Ozil IP) and intraocular foldable lens implantation were performed simultaneously in 14 patients in conventional group (Group 1) and 18 patients in single-layered temporal inverted ILM flap group (Group 2). All patients received retrobulbar anesthesia. After core vitrectomy, a posterior vitreus detachment was induced with the cutter aided by triamcinolone staining if required. In Group 1, a small drop of perfluorocarbon liquid (C10F18; EFTIAR Decalin, DORC) was injected into the eye to cover the hole using a 27-gauge blunt cannula. Brilliant Blue G (BBG) was slowly injected around the perfluorocarbon liquid (PFCL) to stain the ILM. BBG was removed 30 s later with a backflush needle and followed by perfluorocarbon bubble aspiration. Then the ILM was completely peeled in a circular fashion at least a 1.5 disc radius from the hole. In Group 2, a larger (6-disc diameters) bubble of PFCL was used to cover the hole, followed by crescent-shaped selective ILM staining as previously described by our group.13
TRPA1 as a therapeutic target for nociceptive pain
Published in Expert Opinion on Therapeutic Targets, 2020
Daniel Souza Monteiro de Araujo, Romina Nassini, Pierangelo Geppetti, Francesco De Logu
In 2011–2012, powerful antagonists of the TRPA1 channel were found among the derivatives of decalin (WO/2011/043954) and derivatives of proline (WO/2012/152983 A1) [100,101]. In 2013 and 2017, heterocyclic amides were also tested as TRPA1 antagonists (WO2013/108857 A1, WO/2017/135462 A1) [102]. Recently, some arylamide derivatives, carbamate compounds, azabenzofuran and 5-(2-(trifluoromethyl) phenyl)-indazoles, have been reported as TRPA1 antagonists with potency, metabolic stability, and considerable solubility [103,104]. In 2017, bicyclic heterocycle derivatives were patented as TRPA1 receptor antagonists (WO/2017/060488 A1). In 2018, the possibility of using ophthalmic preparations for the dispensing of eye drops for the treatment of eye diseases using TRPA1 antagonists was reported (WO/2018/009717 A1).
Dyhidro-β-agarofurans natural and synthetic as acetylcholinesterase and COX inhibitors: interaction with the peripheral anionic site (AChE-PAS), and anti-inflammatory potentials
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Julio Alarcón-Enos, Evelyn Muñoz-Núñez, Margarita Gutiérrez, Soledad Quiroz-Carreño, Edgar Pastene-Navarrete, Carlos Céspedes Acuña
In a previous work carried out by Alarcón et al.,25 sesquiterpene esters with a dihydro-β-agarofuran skeleton were isolated from Chilean Celastraceae and it was found that most of the compounds had inhibitory activity on AChE. The IC50 values for said compounds were found in the range of 0.046 to 0.738 mM. When comparing the results, it can be seen that the synthesised dihydro- β -agarofurans have a better AChE inhibitory activity than the compounds isolated from plants. These results show that there would be a possible relationship between the size of the substituents surrounding decalin and its inhibitory activity. Synthetic compounds with less bulky groups would have better AChE enzyme inhibitory activity.