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Antiseptics *
Published in Bev-Lorraine True, Robert H. Dreisbach, Dreisbach’s HANDBOOK of POISONING, 2001
Bev-Lorraine True, Robert H. Dreisbach
Boric acid (H3BO3) is a white compound that is soluble to the extent of 5% in water at 20°C. Sodium borate, or borax (Na2B4O7·10H2O), is a white compound that is soluble to the extent of 14% in water at 55°C. Sodium perborate (NaBO3·4H2O) is a white compound that is slightly soluble in cold water and decomposes in hot water. Boron oxide is used in industry. Pentaborane, decaborane, and diborane are used as propellants.
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Michael Kugler, Josef Holub, Jiří Brynda, Klára Pospíšilová, Suzan El Anwar, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, Milan Fábry, Bohumír Grüner, Pavlína Řezáčová
The series of sulphonamido carboranes contained a sulphonamidoalkyl group attached to alternative clusters: 1,2-dicarba-closo-dodecaborane (here referred to as closo clusters) or 7,8-dicarba-nido-undecaborate(1-) (here referred to as nido clusters). Compounds containing an alkyl linker with a length of n = 1 to n = 4 (compounds 1a–4a and 1 b−–4b−) were designed and synthetised in our previous work35. Synthesis of compounds with a longer linker length of n = 5 and n = 6 between the sulfonamide group and the carborane cluster (compounds 5a–6a and 5 b−–6b−) was carried out using a procedure analogous to the one used for the carboranes with shorter linkers (Scheme 1). The respective sulphonamido acetylenes were inserted into open-cluster 6,9-(Me2S)-arachno-decaborane(12) producing sulphonamidoalkyl 1,2-dicarba-closo-dodecaboranes 5a and 6a, respectively. Using a solution of KOH in methanol, these were degraded to the respective 7-substituted derivatives of eleven vertex [7-NH2SO2-(CH2)n-7,8-nido-C2B9H12]− ions 5 b− and 6 b− (n = 5 and 6, resp.).