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Survey of Indigenous Knowledge of Medicinal Plants in India
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Acharaya Balkrishna, Nishant Gupta, Deepak K. Gond, Ishwar P. Sharma, Rachana Bhandari, Vedpriya Arya
Datura metel and Datura innoxia are used by natives for treatment of cancer in the selected study areas. In other previous studies, Helicteres isora [13–15] was reported for cancer treatment. Various herbal remedies have been studied for different genito-urinary ailments (such as infertility, gynecological disorders, urinary disorders, sexual weakness, menstrual problems, etc.) [8, 9, 24, 29].
Traditional Medicinal Plants for Respiratory Diseases: Mexico
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Assessment of Medicinal Plants for Human Health, 2020
Armando Enrique González-Stuart, José O. Rivera
The genus Datura contains various species that are hallucinogenic and have been used for centuries in magic and healing rituals.57 The medicinal and hallucinogenic uses of toloache were banned by the Mexican government many years ago, owing to the potential toxicity of its internal use. The plant contains various tropane alkaloids (including scopolamine and hyoscyamine), found in other species of the nightshade family, to which it belongs. For many decades, D. stramonium was included in the pharmacopeias of Mexico, the United States, as well as many other countries in America and Europe. Various respiratory diseases, especially asthma, have been traditionally treated using this plant by means of various preparations including powders and cigarettes made from the leaves. The tropane alkaloids do indeed have bronchodilating effect, but are not safe to use, especially in children.58
Medicinal Plants of Central Asia
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Farukh S. Sharopov, William N. Setzer
Datura stramonium L. (Solanaceae) (Durman vonyuchego (Russian), Bangi devona (Tajik)) probably originated in the Neotropics but has been introduced worldwide where it has become an aggressive invasive weed (Witt and Luke, 2017). A decoction of the seeds is used as a gargle to treat toothache and headache, as an analgesic, sedative, antipyretic, and anti-inflammatory (Sharopov and Setzer, 2018; Egamberdieva and Jabborova, 2018; Zaurov et al., 2013). The flowers are pounded and applied externally on the forehead to relieve headaches and on the eyes to treat pains in the eyes (Sezik et al., 2004). All parts of the plant contain tropane alkaloids, principally atropine, hyoscyamine, and scopolamine (Figure 4.8) (Das et al., 2012; Gaire and Subedi, 2013; Singh and Singh, 2013).
In vitro cytotoxicity of polyphenols from Datura innoxia aqueous leaf-extract on human leukemia K562 cells: DNA and nuclear proteins as targets
Published in Drug and Chemical Toxicology, 2020
Elham Chamani, Roshanak Ebrahimi, Khatereh Khorsandi, Azadeh Meshkini, Asghar Zarban, Gholamreza Sharifzadeh
Interest has increased globally on the use of medicinal plants (Quansah and Karikari 2016). The genus Datura from the Solanaceae family has a long and clear history in traditional medicine (Śramska et al. 2017). Species such as Datura stromonium, Datura innoxia, and Datura metel contain flavonoid and alkaloid compounds. Datura innoxia is an annual with a vegetal stem and large, pale green leaves (Figure 1(A)). This plant is funnel-shaped with white flowers, five stamens, and a superior ovary (Schultes and Hofmann 1979, Fatima et al. 2015). Because of the fragrant odor of the flowers at night, D. innoxia is also known as moon flower and it is cultivated as a woody ornamental (De Wolf 1956). Datura innoxia differs from D. stromonium in having small flowers and smooth-edged leaves (Figure 1(B)) (Kayani et al. 2014). The seeds are black and disk-shaped. The fruit is thorny and are known as thorn apples (Fatima et al. 2015).
Datura and Brugmansia plants related antimuscarinic toxicity: an analysis of poisoning cases reported to the Taiwan poison control center
Published in Clinical Toxicology, 2019
Uyen Vy Doan, Ming-Ling Wu, Dong-Haur Phua, Bomar Mendez Rojas, Chen-Chang Yang
Table 2 shows the clinical characteristics of patients with Datura or Brugmansia plant poisoning. In most cases, parts of the plant were cooked or boiled before ingestion. Sixteen of the cases ingested tea with Datura/Brugmansia leaves or flowers. Six patients consumed raw Datura/Brugmansia flowers. One patient smoked cigarette that was rolled with the leaves of D. metel to treat asthma. The elapsed time after Datura/Brugmansia exposure was known in only 84 cases (41.4%), and was similar between patients with severe and non-severe poisoning. Signs and symptoms of Datura/Brugmansia poisoning in this study are listed in Table 2.
Datumetine exposure alters hippocampal neurotransmitters system in C57BL/6 mice
Published in Drug and Chemical Toxicology, 2022
Azeez Olakunle Ishola, Aminu Imam, Moyosore Salihu Ajao
In Nigeria, 27 thousand people had been reported to be exposed to the use of datura with 0.03 prevalence rate (United Nations Office on Drugs and Crime (UNODC) 2018). Despite this number, deaths have been reported in the national dailies where datura extract was added to the alcoholic drinks to increase intoxication. Long term use of the plant has been reported to induce psychosis in humans (Khanra et al.2015). Recreational users of datura suffer memory loss during the phase of intoxication, this led to the hypothesis that datura may possess compound(s) that affect hippocampal functioning.