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Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
p-Cymene is a colorless to pale yellow clear liquid; its odor type is terpenic and its odor at 1% in dipropylene glycol is described as ‘fresh citrus terpene woody spice’ (www.thegoodscentscompany.com). p-Cymene is used to improve the odor of soaps, detergents and sanitation goods and as a masking odor for industrial products. It also acts as the starting material for the production of p-cresol, carvacrol and acetyl hexamethyl tetralin. Other uses include or have included as a solvent for dyes, varnishes and lacquers, as heat-transfer fluid, in metal polishes and in the manufacture of synthetic resins (U.S. National Library of Medicine).
Chemistry of Essential Oils
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
Myrcene (70) is very widespread in nature. Some sources, such as hops, contain high levels and it is found in most of the common herbs and spices. All isomers of α-ocimene (84), β-ocimene (85), and allo-ocimene (86) are found in essential oils, the isomers of β-ocimene (85) being the most frequently encountered. Limonene (73) is present in many essential oils, but the major occurrence is in the citrus oils that contain levels up to 90%. These oils contain the dextrorotatory (R)-enantiomer, and its antipode is much less common. Both α-phellandrene (87) and β-phellandrene (88) occur widely in essential oils. For example, (−)-α-phellandrene is found in Eucalyptus dives and (S)-(−)-b-phellandrene in the lodgepole pine, Pinus contorta. p-Cymene (83) has been identified in many essential oils and plant extracts and thyme and oregano oils are particularly rich in it. α-Pinene (65), β-pinene (76), and 3-carene (77) are all major constituents of turpentine from a wide range of pines, spruces, and firs. The pinenes are often found in other oils, 3-carene less so. Like the pinenes, camphene (89) is widespread in nature.
Pharmacokinetics behaviors of l-menthol after inhalation and intravenous injection in rats and its inhibition effects on CYP450 enzymes in rat liver microsomes
Published in Xenobiotica, 2019
Xiuli Feng, Yan Liu, Xiao Sun, Ang Li, Xiaoyan Jiang, Xiaosong Zhu, Zhongxi Zhao
Phenacetin, testosterone, dextromethorphan, omeprazole, tolbutamide, chlorzoxazone, β-NADP and β-NADPH were purchased from Sigma-Aldrich Chimie (Saint Quentin Fallavier, France). l-Menthol (purity >98%) was bought from Melun Biotechnology Co., Ltd. (Dalian, China). P-cymene (purity >95%) was obtained from Tokey Chemical Industry Co., Ltd. (Tokyo, Japan). Formic acid and tris(hydroxymethyl)aminomethane (Tris) were purchased from Beijing Chemical Reagents Company (Dongdan, Beijing, China). Rat liver microsomes were bought from Ruide Research Institute for Liver Disease Co. Ltd (Shanghai, China). HPLC-grade acetonitrile was purchased from Tedia Company (Fairfield, OH). All liquids used for the experiments were filtered through 0.22-μm membrane filters from Millipore (MA). Ultrapure helium (purity of 99.999%) was purchased from Jinan Deyang Special Gases Co., Ltd (Jinan, China).
Therapeutic Potential of Zataria multiflora Boiss in Treatment of Irritable Bowel Syndrome (IBS)
Published in Journal of Dietary Supplements, 2019
According to the GC-MS analysis of Z. multiflora essential oils by different GC-MS columns (Table 2), the essential oil from Z. multiflora dried aerial parts (Kashan, Iran) had thymol (38.7%), carvacrol (15%), p-cymene (10.2%), and γ-terpinene (9.8%) as its main components (Mahboubi and Bidgoli, 2010). This essential oil belonged to thymol, carvacrol, and p-cymene chemotype. Comparing the 18 samples of essential oil from natural populations across different provinces of Iran, including Sistan and Baluchestan, Hormozgan, Kerman, Fars, Yazd, Isfahan, and Bushehr, showed thymol (6%–54.9%), carvacrol (0.7%–50.6%), p-cymene (1.6%–14.8%), linalool (1.2%–46.8%), carvacrol methyl ether (1.0%–11.6%), and trans caryophyllene (0.2%–8.4%) as the main components (Hadian et al., 2011).
Metabolism and pharmacokinetics studies of allyl methyl disulfide in rats
Published in Xenobiotica, 2019
Yan Liu, Ang Li, Xiaoyan Jiang, Xiaosong Zhu, Xiuli Feng, Xiao Sun, Zhongxi Zhao
P-cymene was adopted as the internal standard for the determination based on our preliminary and published studies (Germain et al., 2002; R. Artacho Martin-lagos MFOSMDRL, 1995). AMDS (1 μl) was added to 199 μl of rat erythrocytes and incubated for 5 min at 37 °C. After incubation, 400 μl of acetonitrile which contained p-cymene as an internal standard at the concentration of 37.5 μg/ml were added to the incubation mixture in order to terminate the reaction. Next, the mixture was vortexed for 10 min and then centrifuged at 12 000g for 10 min. Finally, after filtered through a 0.22 μm microporous membrane, 1 μl of the supernatant was injected into GC–MS for the identification of the metabolites of AMDS in the incubation mixture with rat erythrocytes.