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Other Reactions from Gloves
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
T. Bullock, A. Sood, J.S. Taylor
Pyrethroid insecticides (cypermethrin and beta-cyfluthrin) from an insect sprayer were reported to have caused chemical leukoderma on the head, trunk, and extremities of a patient who worked for 15 years spraying insecticides.94 Hexamethylenetetramine, a chemical found in adhesives and sealants, was reported to cause chemical leukoderma in a factory worker who mixed adhesives, chemicals, and other raw materials together to produce automobile materials.95 In China, two cases of chemical leukoderma due to dimethyl sulfate, a chemical used in the production of pharmaceuticals, perfumes, and pesticides, were recently described.96
The role of lifestyle factors in recurrent implantation failure
Published in Efstratios M. Kolibianakis, Christos A. Venetis, Recurrent Implantation Failure, 2019
Vicki Nisenblat, Robert J. Norman
Exposure to pesticides has been linked with pubertal abnormalities, menstrual irregularities, decreased fecundity, miscarriage, and risk of endometriosis in human and animal studies.4,83 Occupational exposure to certain pesticides, including DDT, is inversely associated with sperm parameters and male reproductive hormones.83 The authors of a systematic review of the available literature concluded that DDT did not seem to affect oocyte quality, fertilization, embryo development, or pregnancy rate in IVF patients.90 More recent data showed a significantly reduced implantation rate in women with high follicular fluid of DDT and several other pesticides (lindane, diazinon, and chlorpyrifos).91 The authors also found a significant inverse correlation between follicular fluid concentrations of the examined pesticides (DDT, lindane, diazinon, malathion, chlorpyrifos, bioallethrin, pretilachor, and b-cyfluthrin) on endometrial thickness. However, the effect of these chemicals on clinical pregnancy and live birth rate has not been evaluated.
Cannabis testing: Taking a closer look
Published in Betty Wedman-St. Louis, Cannabis, 2018
Scott Kuzdzal, Robert Clifford, Paul Winkler, Will Bankert
With an enormous number of pesticides available in the commercial marketplace, no lab can test for all of them. The number of pesticides required for testing varies from state to state, ranging from zero to proposed rules in California for 66 pesticides. Organizations such as AOAC International are evaluating methods with more pesticides. Shimadzu's high-sensitivity LCMS-8050 triple-quadruple liquid chromatograph mass spectrometer can analyze 211 pesticides in cannabis dry product in less than 12 minutes. Because the pesticide list varies from state to state and country to country, and is subject to change, the addition of a GC-MS/MS may be required for complete pesticide analysis. Choose the triple quadrupole GSMS-TQ8050 with AOC-6000 autosampler for volatile pesticides, pesticides that are difficult to analyze by electrospray ionization (ESI), and other problematic pesticides, such as Captan, Chlordane, Chlorfenapyr, Cyfluthrin, Cypermethrin, Dichlorvos, Parthion Methyl, and Pentachloronitrobenzene (Quintozine), difficult to analyze by LC-MS/MS.
A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides
Published in Critical Reviews in Toxicology, 2022
Benjamin A. Elser, Benjamin Hing, Hanna E. Stevens
Compared to the findings regarding neurodevelopment, links between pyrethroid exposure and fetal growth outcomes are more mixed within the epidemiological literature. While the correlation between pyrethroid exposure and low birth weight has also been noted in academic and regulatory studies, these effects often occur at doses that either exceed relevant human exposures or co-occur with maternal toxicity. In the DNT studies for beta-cyfluthrin and zeta-cypermethrin, reductions in fetal weight were noted at doses below that which induce decreases in maternal body weight and food consumption, suggesting an effect independent of maternal toxicity that deserves additional investigation. In general, though, the lack of correlation between birth weight and neurodevelopmental outcomes in the epidemiological literature suggests that any potential effects on the developing brain are unlikely to be secondary to general fetal growth effects. However, for such mediator questions, larger-scale studies would be needed. Furthermore, although several epidemiological studies have suggested a risk for birth defects, the small number of studies finding significant outcomes and the lack of supporting data from animal studies suggest that these may be of less concern.
Exposure to pyrethroids induces behavioral impairments, neurofibrillary tangles and tau pathology in Alzheimer’s type neurodegeneration in adult Wistar rats
Published in Drug and Chemical Toxicology, 2022
K. A. Iteire, A. T. Sowole, B. Ogunlade
A multipurpose pyrethroids insecticide, product of Johnson Wax Nigeria Limited, Lagos, Nigeria with the following composition: Cyfluthrin, 0.015%; Imiprothrin, 0.05%; Prallethrin, 0.05%; and undisclosed inert ingredients, 99.885% was purchased from a local supermarket close to the University of Medical Sciences, Ondo City, Ondo State, Nigeria. This chemical was registered with a National Agency for Food and Drug Administration and Control (NAFDAC) number of 048724. Phospho-Tau (Ser404) (D2Z4G) Rabbit mAb (−20 °C) purchased from Cell Signaling Technology USA and GFAP (2E1): sc- 33673 (4 °C) was purchased from Santa Cruz Biotechnology, INC, USA were used for immunohistochemistry.
In vitro cytotoxicity and genotoxicity of Furia®180 SC (zeta-cypermethrin) and Bulldock 125®SC (β-cyfluthrin) pyrethroid insecticides in human peripheral blood lymphocytes
Published in Toxicology Mechanisms and Methods, 2018
María Elena Calderón-Segura, Sandra Gómez-Arroyo, Josefina Cortés-Eslava, Carmen Martínez-Valenzuela, Luis Humberto Mojica-Vázquez, Magdiel Sosa-López, Diana Flores-Ramírez, Zaira Edtih Romero-Velázquez
The commercial insecticide Furia®180 SC (zeta-cypermethrin) was purchased from Agrochemical Mexico and diluted (1:30) with deionized water. The commercial insecticide Bulldock (β-cyfluthrin) pyrethroid, donated from Cropscience Bayer, Mexico (with 480 g a.i./L) (RSCO-INAC-0102 T-301-064-040), was diluted (1:20) with deionized water. The dilutions of both pesticides that induced DNA damage in human peripheral lymphocytes were determined from preliminary experiments with viability ≥92%, and these concentrations were used in three independent experiments.