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Traditional Malay Ulam for Healthy Ageing
Published in Goh Cheng Soon, Gerard Bodeker, Kishan Kariippanon, Healthy Ageing in Asia, 2022
Jamia Azdina Jamal, Khairana Husain
Oral administration of ethanol (50%) Curcuma zedoaria rhizome extract (200 and 400 mg/kg) for 12 days reduced total serum cholesterol and LDL cholesterol levels in male rats with hyperlipidaemia induced by poloxamer 407, but the results were not comparable to atorvastatin (75 mg/kg). Its effect may be attributed to the alkaloid content (Srividya et al. 2012).
Biotransformation of Sesquiterpenoids, Ionones, Damascones, Adamantanes, and Aromatic Compounds by Green Algae, Fungi, and Mammals
Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020
Yoshinori Asakawa, Yoshiaki Noma
Germacrone (118), (+)-germacrone-4,5-epoxide (119), and curdione (120) isolated from Curcuma aromatica, which has been used as crude drug, were incubated with A. niger. From compound 119 (700 mg), two naturally occurring metabolites, zedoarondiol (121) and isozedoarondiol (122), were obtained (Takahashi, 1994). Compound 119 was cultured in callus of Curcuma zedoaria and C. aromatica to give the same secondary metabolites 121, 122, and 124 (Sakui et al., 1988) (Figures 23.40 and 23.41).
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
The Botanical Safety Handbook notes no known drug interactions with either Curcuma longa or Curcuma zedoaria.20 Curcumin did inhibit recombinant human CYP1A2, CYP3A4, CYP2D6, CYP2C9, and CYP2B6 enzymes. However, this occurred at mid-micromolar concentrations and, due to relatively low exposure of the liver to ingested curcumin, effects on drug metabolism by the liver may be minimal.21
Formulation and evaluation of a topical liposomal gel containing a combination of zedoary turmeric oil and tretinoin for psoriasis activity
Published in Journal of Liposome Research, 2021
Ji Chen, Yanqiao Ma, Yueying Tao, Xiaoqian Zhao, Yongai Xiong, Zehui Chen, Yingbiao Tian
Curcuma zedoaria is a commonly used TCM, originated from turmeric plants in the family Curcumae (Jung et al.2018). Zedoary turmeric oil (ZTO) is a volatile oil obtained from zedoary turmeric by steam distillation, which mainly include furanodiene, germacrone and zedoarondiol (Huang et al.2019). Previous work on ZTO (Song et al.2001) have shown that it can be used as a local drug in treating psoriasis, and its mechanism may be to inhibit the proliferation of keratinocytes and promote the normal differentiation of keratinocytes. Tretinoin (TRE) is adjunctive therapy for psoriasis, and trace TRE can regulate the terminal differentiation of keratinocytes and inhibit its proliferation. Our previous studies (Tian et al.2009) have shown that the combination of the ZTO and TRE can be used in the treatment of psoriasis. However, both of them have the disadvantages of poor water solubility and stability (Raza et al.2013, Xu et al.2017), which limits their application.
Recent progress in the development of β2 adrenergic receptor agonists: a patent review (2015-2020)
Published in Expert Opinion on Therapeutic Patents, 2021
Gang Xing, Ce Yi, Peiyuan Dou, Zhengxing Zhi, Bin Lin, Maosheng Cheng
Liang et al. disclosed three new natural products in Patent CN109806254 [49] with β2AR agonistic activities isolated from curcuma zedoaria, which is widely distributed in southwestern regions of China, including Guangxi, Sichuan, Guangdong, and Yunnan Provinces [50]. These were compounds with diphenylheptane scaffold named compound a (9), compound b (10), and compound c (11) in the patent (Figure 2). The activities of compounds were evaluated in the A431 human epidermal cancer cells. Although the activity of compound c was not reported in the patent, it was reported that compounds a and b have the agonistic activity to the β2AR with the β2 EC50 values of 23.82 ± 1.04 μM and 5.925 ± 1.131 μM, respectively. These new natural β2AR agonists could be potential candidates for further drug development of pulmonary diseases.
Qici Sanling decoction suppresses bladder cancer growth by inhibiting the Wnt/Β-catenin pathway
Published in Pharmaceutical Biology, 2019
Hua Gong, Weihua Chen, Lanhua Mi, Dan Wang, Youkang Zhao, Chao Yu, Aiguang Zhao
Traditional Chinese medicine (TCM) is widely used in China. Qici Sanling decoction (QCSL), a TCM, is made of the radix of Astragalus propinquus Schischkin (Fabaceae) [huangqi], the corm of Sagittaria sagittifolia L. (Alismataceae) [cigu], the sclerotium of Polyporus umbellatus (Pers.) Fr. (Polyporaceae) [zhuling], the sclerotium of Poria cocos (Schw.) Wolf (Polyporaceae) [fuling], the radix of Paeonia lactiflora Pall. (Paeoniaceae) [baishao], the radix of Curcuma zedoaria (Christm.) Rosc. (Zingiberaceae) [ezhu], the twig of Cinnamomum cassia (L.) J.Presl Blume (Lauraceae) [guizhi], the radix of Glycyrrhiza glabra L. (Fabaceae) [gancao], the radix of Rehmannia glutinosa (Gaertn.) DC (Orobanchaceae) [shudi], and the rhizome of Smilax glabra Roxb. (Smilacaceae) [tufuling] at a ratio of 10:10:5:5:5:5:3:2:5:5 in dry weight. In our previous study (Yu et al. 2018), we found that QCSL combined with pirarubicin for treatment of postoperative patients with non-muscle invasion bladder cancer could significantly reduce the cancer recurrence rate, enhance the systemic immunity, and alleviate the side effects caused by chemotherapy drugs.