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Nutraceuticals and Brain Disorders
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Akshada Atul Bakliwal, Vijay Sharadkumar Chudiwal, Swati Gokul Talele
Corn’s commitment to heart wellbeing lies in its fiber, however, in the critical measures of folate that corn supplies. Corn keeps up the homocysteine, a middle of the road item is a significant metabolic procedure called the methylation cycle. Homocysteine is straightforwardly in charge of harm of vein coronary episode, stroke, or fringe vascular malady. It has been assessed that utilization of 100% of the daily value (DV) of folate would, without anyone else, diminish the quantity of coronary failures endured by 10%. Corn additionally contains cryptoxanthin, a characteristic carotenoid color. It has been discovered that cryptoxanthin can lessen the danger of lung malignant growth by 27% on everyday utilization.
Chemopreventive Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
β-Cryptoxanthin (Figure 12.40) is a naturally occurring carotenoid pigment found in many plant-based foods such as fruits from the genus Physalis (e.g., groundcherries), orange rind, apples, oranges, nectarines, tangerines, peaches, carrots, red peppers, pumpkins, butternut squash, peas, and many other fruits and vegetables, where its consumption has led to reports of anticancer effects, although the potential mechanisms involved are not clear. It is also found in butter and egg yolk, thus adding to the dietary intake. In its pure form, cryptoxanthin is a red crystalline solid with a metallic luster which is highly lipophilic, and freely soluble in chloroform and benzene. It has been used as a food dye (INS number 161c) in some parts of the world. Structurally, it is closely related to β-carotene, differing only in the addition of a 3R-hydroxyl group. It contains β-ionone rings and so has provitamin-A activity.
Chemical and Functional Properties of Amazonian Fruits
Published in Luzia Valentina Modolo, Mary Ann Foglio, Brazilian Medicinal Plants, 2019
Elaine Pessoa, Josilene Lima Serra, Hervé Rogez, Sylvain Darnet
β-Cryptoxanthin is the principal carotenoid present in the fruit, pulp and juice, and represents more than 50% of the total vitamin A content. Other carotenoids found in the pulp are lutein, zeaxanthin, β-carotene and α-carotene. Of these compounds, only α-carotene, β-carotene and β-cryptoxanthin have provitamin A activity. The pulp should be considered to be a good source of provitamin A because 100 g provides 37.2% of the RDI for adults (Hamano and Mercadante, 2001; Tiburski et al., 2011).
Encapsulation of Nutraceutical Ingredients in Liposomes and Their Potential for Cancer Treatment
Published in Nutrition and Cancer, 2018
Sayantani Dutta, Jeyan Arthur Moses, C. Anandharamakrishnan
β-Cryptoxanthin is one of the major carotenoids in yellow or orange fruits and vegetables. It has also been associated with anticancer activity against lung, bladder, breast, and colon cancer (36). β-cryptoxanthin liposomes have been reportedly formulated by researchers to enhance its anti-proliferative activity against human leukemia K562 cell line, when contesting the non-encapsulated compound (36). The results indicated that nanoliposomal formulation enhanced (P < .001) the anticancer efficacy of β-cryptoxanthin in comparison to its free form, in both dose- and time-dependent manners. Hoechst staining of K562 cells treated with β-cryptoxanthin illustrated that nanoliposomal β-cryptoxanthin had increased cellular apoptosis, evident by nuclear fragmentation and chromatin condensation. Therefore, the β-cryptoxanthin liposome can be used for leukemia therapies in the future.
Association of Serum Carotenoids and Retinoids with Intraprostatic Inflammation in Men without Prostate Cancer or Clinical Indication for Biopsy in the Placebo Arm of the Prostate Cancer Prevention Trial
Published in Nutrition and Cancer, 2022
Susan Chadid, Xiaoling Song, Jeannette M. Schenk, Bora Gurel, M. Scott Lucia, Ian M. Thompson, Marian L. Neuhouser, Phyllis J. Goodman, Howard L. Parnes, Scott M. Lippman, William G. Nelson, Angelo M. De Marzo, Elizabeth A. Platz
In this subset of controls from the placebo arm of the PCPT, we found no association of serum concentrations of lycopene, α-carotene, β-carotene, and retinol with intraprostatic inflammation. Higher serum β-cryptoxanthin level was positively associated with both the presence and extent of intraprostatic inflammation for tertile 2 but not for tertile 3. These patterns for β-cryptoxanthin were also observed when restricting to controls not enriched for oxidative states such as cigarette smoking or diabetes. We conducted this study in a setting in which the opportunity to investigate the link of carotenoids and retinol with intraprostatic inflammation was less likely to be biased by clinical indication for biopsy. Nevertheless, the findings did not support our hypothesis.
Association of Carotenoid Intake with Pulmonary Function
Published in Journal of the American College of Nutrition, 2021
According to USDA Food Composition Databases (17), foods that are high in α-carotene include carrots and winter squashes. β-carotene is rich in sweet potatoes, carrots, and greens such as spinach. β-cryptoxanthin is rich in winter squashes and oranges. Statistical correlations in the ARIC dataset indicated that intake of all fruits, vegetables, legumes, and nuts were significantly associated with dietary α-carotene, β-carotene, and β-cryptoxanthin levels. Processed foods such as commercially baked goods, meats, eggs, dairy, and wine had limited or no associations with these carotenoids.