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Medicinal Plants of the Trans-Himalayas
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Ajay Sharma, Garima Bhardwaj, Pushpender Bhardwaj, Damanjit Singh Cannoo
Cold desert conditions, prolonged frozen winters, and remoteness drove exploration of the value of edible wild plants (e.g., Lepidium sp., Rhodiola sp., Urtica sp., Taraxacum sp.), fodder plants (e.g., H. rhamnoides, P. pabularia, Cicer microphyllum, Aconogonum tortuosum). The plants with aesthetic value include Rosa sp., Primula sp., Meconopsis sp., Epilobium sp., and A. fragrans. Examples of plants for fuel are H. rhamnoides, Caragana sp., Berberis sp., Artemisia sp., and Acantholimon lycopodioides. Medicinal plants include Aconitum sp., Anaphalis sp., Arnebia sp., Artemisia sp., Berberis sp., Codonopsis sp., Colchicum sp., Corydalis sp., Ephedra sp., Gentiana sp., Hippophae sp., Inula sp., Nepeta sp., Podophyllum sp., Ranunculus sp., Rheum sp., Rhodiola sp., and Saussurea sp. (Chaurasia et al., 2007; Ballabh et al., 2007; Ballabh and Chaurasia, 2007; Dorjey, 2015; Dorjey et al., 2012).
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Corydalis yanhusuo is a genus of about 470 species of herbaceous plants in the Papaveraceae family, native to the temperate zones of Asia and eastern Africa. Corydalis Rhizoma, named Yuan Hu in China, is the dried tuber of Corydalis yanhusuo. This species has been used for centuries in Chinese and Korean schools of medicine for pain relief. Recent studies utilizing modern experimental and statistical methods have confirmed the pain-relieving effects of corydalis. Indeed, the herb appears to be as effective as the NSAID diclofenac for osteoarthritis pain, with fewer adverse side effects.1
Phytoextracts and Their Derivatives Affecting Neurotransmission Relevant to Alzheimer’s Disease
Published in Akula Ramakrishna, Victoria V. Roshchina, Neurotransmitters in Plants, 2018
The extracts of Corydalis solida (Family: Papaveraceae) and Buxus sempervirens (Family: Buxaceae) showed remarkable AChE inhibitory activity above 50% inhibition rate at 1 mg/mL. Genera salvia of Lamiaceae family also exhibited anticholinesterase as well as nicotinic activity, and many of them are successfully screened for clinical trials now as anti-dementia drugs (Perry et al., 2000, 2001).
Bioactivation of herbal constituents: mechanisms and toxicological relevance
Published in Drug Metabolism Reviews, 2019
Mechanism-based inactivation and MI complex formation of CYP3A4 by MDP-bearing lignans from Acanthopanax chiisanensis (Yoo et al. 2008) and Piper cubeba (Usia et al. 2005) have also been reported. Corynoline, a di-MDP alkaloid isolated from Corydalis bugeana Turcz., formed reactive o-quinone species via metabolic activation of the MDP moieties (Mao et al. 2015; Liu et al. 2018). Other MDP-containing herbal constituents included benzophenanthridine alkaloids chelidonine and nitidine chloride, both of which were found to be mechanism-based inactivators of CYP2D6 (Mao et al. 2018; Liu et al. 2019). Several alkenylbenzenes described above, such as safrole and myristicin, also contain a MDP moiety. Whilst sulfation of the 1′-hydroxy metabolites is held to be central to carcinogenicity of these alkenylbenzenes (Rietjens et al. 2005), the hepatotoxicity of safrole is likely dependent on its demethylenation of the MDP moiety to the catechol, followed by oxidation to the allyl-o-quinone and tautomerization to the more electrophilic vinyl p-quinone methide (Bolton et al. 1994) (Figure 9(c)).
Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry
Published in Xenobiotica, 2019
Liwei Chai, Paul Owusu Donkor, Kun Wang, Yingjie Sun, Mahmood Brobbey Oppong, Kai Wang, Liqin Ding, Feng Qiu
Corydaline is one of the main isoquinoline alkaloids obtained from the rhizomes of Corydalis yanhusuo, which has been used as a traditional Chinese medicine due to its analgesic and antiulcer effects (Kubo et al., 1994; Matsuda et al., 1995; Yuan et al., 2004). Pharmacological investigations indicate that corydaline inhibits cyclin-dependent kinase 2 (CDK2) (Tang & Chen, 2014), neuraminidase (NA) (Kim et al., 2014) and thrombin-induced platelet aggregation (Zhang et al., 2016) facilitates gastric accommodation (Lee et al., 2010) and inhibits acetylcholinesterase and butyl cholinesterase inhibitory activities (Adsersen et al., 2007; Berkov et al., 2008). Besides, it has potential anti-angiogenic (Wei et al., 2017), anti-allergic (Saito et al., 2004) and anti-nociceptive (Wang et al., 2010) effects.
Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway
Published in Immunopharmacology and Immunotoxicology, 2023
Haihua Zhang, Wuying Lang, Sufen Li, Chao Xu, Xiumin Wang, Yunyu Li, Zhiqiang Zhang, Tonglei Wu, Minshan Feng
Corynoline, an active substance extracted from Corydalis bungeana Turcz, has been frequently applied to treat inflammation and influenza [14] since it can reduce expression of pro-inflammatory TNF-α, IL-6 and IL-1β [15]. A previous study reported that corynoline ameliorated acute lung injury via activating the Nrf2 pathway [16]. Besides, corynoline was found to alleviate LPS-induced inflammatory response in human umbilical vein endothelial cells [16]. However, the therapeutic effect of corynoline on UC remains unknown. Based on the above findings, we postulate that corynoline may alleviate UC injury by inhibiting inflammation and oxidative stress via the Nrf2/NF-κB pathway.