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Hydrastis canadensis (Goldenseal) and Lawsonia inermis (Henna)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Md. Mizanur Rahaman, William N. Setzer, Javad Sharifi-Rad, Muhammad Torequl Islam
The major chemical compounds of goldenseal are found in theroots and rhizomes (Pengelly et al., 2012). The plant contains the isoquinoline alkaloids, such as hydrastine, berberine, berberastine, hydrastinine, tetrahydroberberastine, canadine, and canalidine (Weber et al., 2003).The three major alkaloids are berberine, hydrastine, and canadine (Pengelly et al., 2012). Hydrastis canadensis has been indicated to contain isoquinoline alkaloids inthe ranges of 1.5–4% hydrastine, 0.5–6% berberine, and 2–3% berberastine (Hamon, 1990). One study also found the compound 8-oxotetrahydrothalifendine (Gentry et al., 1998).
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Tyler describes it as an interesting but valueless drug.37 Kloss44 and Tierra28 describe it as one of the most wonderful remedies, a real cure-all. Used variously for cancers, especially of the ovary, stomach, and uterus.4 I personally have heard three testimonials for goldenseal for remission in uterine cancer, but, doubtless, there have been more remissions without goldenseal. Alkaloids in Hydrastis show some anticancer activity. Berberine, or its sulfate, has shown activity in the BI, KB, and PS tumor systems.10 Canadine is often known as tetrahydroberberine. “Two tetrahydroprotoberberine alkaloids possessing a transquinolizi-dine conformation displayed in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma.”177 Goldenseal, long used by the Cherokee for eye and skin ailments, is regarded as alterative, antiperiodic, antiseptic, aperient, astringent, detergent, diuretic. and hemostatic. It has served as bitter tonic, as an alterative to the mucous membranes, and has been used as a douche for uterine hemorrhage and for hemorrhoids. Used in some eye lotions. Mixed with red pepper, goldenseal is used as a remedy for chronic alcoholism. Some Indians employed the herb as diuretic, escharotic, and stimulant, using the powder for blistering and the infusion for dropsy. Cures for boils, hemorrhoids, psoriasis, ringworm, and ulcers have been reported. Said to prevent the pitting caused by small pox. Homeopaths prescribe the fresh root for alcoholism, asthma, cancer, catarrh, chancroids, constipation, corns, deafness, dyspepsia, ear, eczema, faintness, fistula, gastric catarrh, glossitis, hemorrhoids, impetigo, jaundice, leucorrhea, lip cancer, liver ailments, lumbago, lupus, menorrhagia, metrorrhagia, mouth sore, nail affections, ozaena, placental adherence, postnasal catarrh, rectal ailments, sciatica, seborrhea, sore mouth, sore nipple, sore throat, stomach ailments, stomatitis, taste disorders, throat ailments, tongue ailments, typhus, ulcers, and uteral afflictions.30 Parvati suggests adding goldenseal and sage to cider vinegar and acidophilous as a douching solution.48 For a brief period, goldenseal was “pushed” as an herb to prevent the detection of morphine in urinalysis, but there is no scientific evidence for such claims.37 But for the other side of the coin, witness the following newspaper clipping.178 Dateline San Diego (WNS): newspapers reported that Ethan Nebelkopf was using goldenseal (with comfrey, mullein, orange peel, and spearmint) as a “detox” tea to help addicts kick their cocaine, heroin, and methadone habits. Nebelkopf said, “People who are into herb-based drugs like heroin and cocaine seem to take naturally to herbal tea.” I wonder, however, how many physicians or nurses would inject goldenseal tea into your bladder with a rubber catheter two or three times a day for bladder ailments, as Kloss recommends.44
Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. refractum var. torquatum with bioactivity studies
Published in Pharmaceutical Biology, 2023
Tuba Kusman Saygi, Nur Tan, Gülbahar Özge Alim Toraman, Caglayan Unsal Gurer, Osman Tugay, Gulacti Topcu
In this study, two known aporphine alkaloids, corydine (1), and isocorydine (2), and two protopine-type alkaloids; one known as protopine (5), another one the new alkaloid glauciumoline (3), were isolated (Figure 2; Table 1) from the aerial parts of the G. grandiflorum subsp. refractum var. torquatum (Aslan 2012), collected from Van, a city located in the Eastern-Anatolia. The other Glaucium species, G. corniculatum var. corniculatum (aerial parts), collected from Konya, afforded five alkaloids. These are a known aporhine alkaloid glaucine (4) and three known protopine type alkaloids; N-methyl canadine (6), trans-protopinium (7) and cis-protopinium (8), in addition to the new protopine-type alkaloid, glauciumoline (3) (Figure 2; Table 1).