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Naturopathic Medicine and the Prevention and Treatment of Cardiovascular Disease
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Pantethine is the stable form of pantetheine, the active form of vitamin B5 or pantothenic acid. Pantothenic acid is the most important component of coenzyme A (CoA). This enzyme is involved in the transport of fats to and from cells, as well as to the energy-producing compartments within the cell. Without coenzyme A, the cell’s fats cannot be metabolized to energy.
Micronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Coenzyme A (abbreviated CoA or CoA-SH), also known as acetyl-CoA, naturally derives from vitamin B5 or pantothenic acid. It has three main components: a 2-mercaptoethylamine unit with free -SH group, pantothenate vitamin (vitamin B3), and ADP part (93). This coenzyme is involved in the reactions of acyl group transfers. Coenzyme A is involved in the biosynthesis of some carbohydrates and fats. Acetyl CoA is an energetically rich compound because of the high energy of the thioester bond (93).
Dyslipidemia
Published in Jahangir Moini, Matthew Adams, Anthony LoGalbo, Complications of Diabetes Mellitus, 2022
Jahangir Moini, Matthew Adams, Anthony LoGalbo
Except for fish oil supplements, no other vitamin, phytochemical, or trace mineral supplements reduce risks for atherosclerosis. Some alternative medicines and health foods have minor effects upon cholesterol and BP. They are not always safe or effective, and may interact with effective prescription medications. Coenzyme Q10 decreases with aging and may be low if certain heart conditions and other chronic diseases are present. Supplementation with this coenzyme has been recommended, but is still of unproven therapeutic benefit.
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats
Published in Drug and Chemical Toxicology, 2023
Mukaddes Gürler, Engin Burak Selçuk, Beyza Güzide Özerol, Kevser Tanbek, Elif Taşlıdere, Azibe Yıldız, Fatma Hilal Yağın, Elif Gürel
Dexpanthenol or D-(+)-Panthenol (Dex) is a familiar therapeutic agent in dermatology, where experimental and clinical studies revealed its favorable effect on wound healing by triggering fibroblast proliferation (Augustin et al.2019, Heise et al.2019, Gorski et al.2020, Saez-Alcaide et al.2020, Kutlu and Metin 2021). Recently, authors investigated Dex performance on different aspects including nerve injury, sepsis, corneal infection, dry nose, diabetic nephropathy, and many other pathologies especially related with oxidative damage (Tutun et al.2019, Korkmaz et al.2020, Kose et al.2020, Mencucci et al.2020, Thieme et al.2020). Dex is a monocarboxylic acid amide ((2 R)-2.4-Didydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamid), and an alcohol derivative of pantothenic acid (vitamin B5). It is essential for the synthesis of coenzyme A (CoA), thus playing a role primarily in lipid metabolism, but also has many other biochemical effects in different sides of metabolism including cell growth, energy generation, and neurotransmitter synthesis (Sanvictores and Chauhan 2020). It supports the cellular defense system against oxidative stress and inflammatory attacks by increasing reduced glutathione and antioxidant enzymes (Ucar et al.2018).
The new European guidelines for prevention of cardiovascular disease are misleading
Published in Expert Review of Clinical Pharmacology, 2020
Uffe Ravnskov, Abdullah Alabdulgader, Michel de Lorgeril, David M. Diamond, Rokuro Hama, Tomohito Hamazaki, Björn Hammarskjöld, Zoe Harcombe, Malcolm Kendrick, Peter Langsjoen, Kilmer S. McCully, Harumi Okuyama, Sherif Sultan, Ralf Sundberg
Statins block the production of both cholesterol and coenzyme Q10. Cholesterol is necessary for a steady renewal of all our cells and for the production of many vital substances, and coenzyme Q10 is necessary for almost all cells to generate energy and normal function. Therefore, it is not surprising that many independent researchers have documented that statin treatment may result in unacceptable side effects which in many cases disappear when the treatment is discontinued [1,47–51]. The most frequent side effect is muscle problems, because muscle cells utilize the most energy in the body and are therefore most directly impaired by coenzyme Q10 deficiency. Considering that today, millions of people are treated with statins, such treatment may be one of the causes of the epidemic of heart failure reported in many countries. In accordance, heart failure is associated with statin use and treatment with coenzyme Q10 is able to treat it [51].
A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Tong Liu, Ning Zhou, Ruihao Xu, Yangang Cao, Yanli Zhang, Zhen Liu, Xiaoke Zheng, Weisheng Feng
Niacin is one of the 13 essential vitamins, and it can be converted to nicotinamide in the human body [38]. Niacin deficit symptoms include several nervous system pathologies, such as dementia and depression, as well as other symptoms resembling those observed in other neurodegenerative diseases [39]. In our study, a low level of niacin in depressed mice was detected. After the administration of Chr and its two active components, the level of nicotinuric acid increased significantly. In terms of energy metabolism, nicotinamide and phosphoribosyl- pyrophosphate combine to generate nicotinamide mononucleotide, which can continue to react with adenosine triphosphate (ATP) to generate coenzyme I. The generation of coenzyme II (NADP) is the result of the combination of coenzyme I and ATP. Coenzyme I and coenzyme II are coenzymes of dehydrogenase and indispensable substance transfer carriers in the human body that participate in the process of lipid metabolism and saccharide anaerobic decomposition. The symptoms of energy deficiency or fatigue in patients with major depression have been described above [36]. Chr and its two active components could increase the level of nicotinuric acid. Furthermore, as a direct metabolite of niacin, the level of nicotinuric acid increased after Chr/Nar/Api treatment, indicating that more niacin exerts its biological activity in the body. Thus, Chr/Nar/Api improved the energy supply by accelerating the niacin and niacinamide metabolism in depressed mice.