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Novel UV Filtering Agents for Next-Generation Cosmetics: From Phytochemicals to Inorganic Nanomaterials
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Cinnamates, salicylates octocrylene, and ensulizole are also active organic UV protective agents. Cinnamates are octinoxate (octyl methoxycinnamate [OMC]) and cinoxate (2-ethoxyethyl-methoxycinnamate). OMC is a potent UVB absorber and is the most frequently used sunscreen ingredient. Salicylates are weak UVB absorbers, and they are generally used in combination with other UV filters. Both octisalate and homosalate are water insoluble that leads to their high substantivity, which is the ability to retain its effectiveness after exposure to water and perspiration. Otocrylene has an excellent safety profile with low irritation, phototoxicity, and photoallergic potential and is used in combination with other UV absorbers to achieve higher SPF formulas and to add stability. Ensulizole or phenylbenzimidazole sulfonic acid is water soluble, and it is used in products formulated to feel lighter and less oily, such as daily use cosmetic moisturizers. It is a selective UVB filter, allowing almost all UVA transmission.
Photoallergy
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
Cinoxate (2-methoxy-ethyl-p-methoxy cinnamate) is an infrequently used agent in sunscreens sold in the United States. It has been reported to cause photoallergic contact dermatitis in Europe.
Sunscreens
Published in Dimitris Rigopoulos, Alexander C. Katoulis, Hyperpigmentation, 2017
Octyl methoxycinnamate is a good UVB absorber but is not as potent as PABA and its esters. Presently, it is the most common sunscreen ingredient in the United States. Although an approved agent, cinoxate is currently not used in any sunscreens in the United States.
Prospects of topical protection from ultraviolet radiation exposure: a critical review on the juxtaposition of the benefits and risks involved with the use of chemoprotective agents
Published in Journal of Dermatological Treatment, 2018
Nilutpal Sharma Bora, Bhaskar Mazumder, Pronobesh Chattopadhyay
Octinoxate and cinoxate are classified as cinnamates, and are non-staining and rarely the cause of any irritation, is currently the most popular UVB filters in the USA (59,60). However, cinnamates require frequent reapplication since they stand at a lower hierarchy in terms of potency and water resistance than padimate O. Encapsulation techniques have been utilized to increase their photostability, however, after sunlight exposure the efficacy and stability of these agents decreases (66).