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Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
In a number of publications, positive patch tests to costus root oil have been reported with unknown, uncertain or unstated relevance. These include (literature screened up to 2014 [2]) the following. One positive patch test reaction to ‘costus oil’ was observed in a group of 460 patients with positive patch tests related to cosmetics; relevance data were not provided (9). Five patients reacted to costus root oil 1% in petrolatum, but had never had contact with the oil. However, they were all allergic to Chrysanthemum x morifolium (Compositae) or to the liverwort Frullania (Jubuilaceae). These plants are known to yield sesquiterpene lactones, and the five patients also showed positive patch test reactions to alantolactone and to some related lactones, which may indicate cross-sensitization to costus root oil (12). Of 3 patients allergic to laurel oil (leaf extract) and laurel essential oil, all co-reacted to costus oil and costunolide (ref. lost during writing).
Increasing the Sensitivity of Adipocytes and Skeletal Muscle Cells to Insulin
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Aqueous extract of Chrysanthemum morifolium given orally to KK-Ay mice at 5% of AIN-93 M diet for 5 weeks had no effect on food intake, body weight, fat mass, liver weight and plasma alanine aminotransferase, and aspartate aminotransferase.244 This supplementation lowered glycemia from about 500 to 300 mg/dL and improved insulin hypoglycemic activity in insulin tolerance test.244 This supplementation decreased insulin resistance by almost 50%.244 This supplementation increased plasma adiponectin and increased the expression of adiponectin in adipose.244 In epididymal white adipose tissues, the extract evoked the expression of peroxisome proliferator-activated receptor-γ and induced peroxisome proliferator-activated receptor-γ downstream targets fatty acid-binding protein, glucose transporter-4 and lipoprotein lipase.244 In epididymal white adipose tissues, the extract evoked a reduction of proinflammatory adipocytokines monocyte chemoattractant peptide-1 and tumor necrosis factor-α and lowered the expression of the macrophage marker F4/80.244 Clinical trials are warranted.
Epstein–Barr Virus and Treatment of Its Infection
Published in Satya Prakash Gupta, Cancer-Causing Viruses and Their Inhibitors, 2014
Tarun Jha, Amit Kumar Halder, Nilanjan Adhikari
In another attempt to find novel natural products, Ukiya et al. isolated 15 pentacyclic triterpene diols and triols from the nonsaponifiable lipid fraction of the edible flower extract of Chrysanthemum morifolium (Ukiya et al. 2002a). All these compounds showed inhibitory effects against EBV-EA activation. Among these, seven compounds showed remarkably high inhibitory effects at higher concentration (100% inhibition at 1 × 103 mol ratio). Calenduladiol (49, Figure 6.8) was found to be the most potent compound among these.
Neuroprotective effects of Chrysanthemum morifolium on cerebral ischemia- reperfusion injury contributes to the oxidative stress suppression and related Keap1/Nrf2 pathway
Published in Brain Injury, 2023
Zibin Zhang, Xiaojun Pang, Yuyu Wei, Huai Chen, Xuhong Jin, Qingping Lv
Chrysanthemum morifolium (Chrysanthemum morifolium Ramat; Hangbaiju) belongs to the Asteraceae family, Chrysanthemum genus. The flower of C. morifolium is widely used in China as a herbal medicine and fragrant flower tea for many disease improvement (10). The flavonoids are the major extracts from C.morifolium that contains a wide range of phytochemicals. Pharmacology researches of C. morifolium show that it has antioxidation (11,12), antimicrobial (13), anti-inflammation (14), anti-tumor (15), anti-hyperlipidemia and hypertension (16) and neuroprotective activity (17). Particularly, various studies focused on its antioxidation activity evidence the profound reactive oxygen free radical scavenging and anti-oxidative damage activities. In addition, previous studies report that the active compounds of C. morifolium displayed strong neuroprotective activity on H2O2-induced neurotoxicity in human neuroblastoma SH-SY5Y cells (18,19). The total flavones extracted from C. morifolium were reported to protect against ischemia-reperfusion (I-R) injury in model rats (20). And this reported neuroprotective effect may critically associate with the antioxidative damage activity.
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis
Published in Pharmaceutical Biology, 2021
Yunfeng Zhou, Chunli Wang, Jiejian Kou, Minghui Wang, Xuli Rong, Xiaohui Pu, Xinmei Xie, Guang Han, Xiaobin Pang
Increasing attention has been paid to the application of natural plants for the prevention and treatment of modern diseases due to their safety and multiple effects. Chrysanthemi Flos (C. Flos) known as ‘Ju Hua’ in China, derived from the dry flowers of Chrysanthemum morifolium Ramat. (Asteraceae), is one of the most frequently used traditional Chinese herb medicines with the function of dispelling wind, dissipating heat, clearing the liver and improving eyesight (Mokaddem-Daroui et al. 2012), and is also used as a health-care edible herb medicine in China. The antimicrobial, antioxidant, cardiovascular protection, anticancer and anti-inflammatory effects of C. Flos have been widely reported (Yuan et al. 2020). Bianliang ziyu is one of the most famous varieties of Chrysanthemum morifolium in Kaifeng, China. Currently, the flower of Bianliang ziyu is only used for ornamental value, but not for medical purpose. Our previous studies have demonstrated that the ethanol extract of Bianliang ziyu flower (BZE) exerted protective effects in alcohol and CCl4-induced liver injury models (Tian et al. 2019). However, the detailed mechanism of BZE in liver protection remains to be illustrated.
Comparison of the antioxidant activities of nonfumigated and sulphur-fumigated Chrysanthemum morifolium cv. Hang-ju induced by oxidative stress
Published in Pharmaceutical Biology, 2021
Hongyan Ma, Shanshan Liu, Wenshan Qu, Qi Huang, Linyuan Li, Fujiang Chu, Yuyun Zhu, Xinlin Lv, Zhimin Wang, Jingjing Zhu
The dry capitulum of Chrysanthemum morifolium Ramat. (Compositae) is a popular traditional Chinese medicine known as ‘Ju Hua’ in China, that is included in the Chinese Pharmacopoeia as Chrysanthemi Flos (Chinese Pharmacopoeia Commission 2015). It is also widely used as an herbal tea, beverage and seasoning due to its unique flavour, colour and health benefits (Lii et al. 2010). Pharmacological studies have shown that C. morifolium possesses multiple activities, and its antioxidant activity is of greatest interest. Indeed, several studies have reported that C. morifolium extracts have antioxidant activity (Chen et al. 2015; Yuan et al. 2015). Oxidative stress is the common mechanism of many cardiovascular disease (CVD) risk factors, which suggests that it plays a central role in CVD (Madamanchi et al. 2005).