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Triethanolamine Polypeptide Oleate Condensate
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Triethanolamine polypeptide oleate condensate (TPOC) is a condensation product of triethanolamine, peptides and oleic fatty acids. It is used as a cerumenolytic drug, a compound to dissolve earwax (1). The name of this chapter is the name used by the manufacturer of eardrops containing the material (Cerumenex®, Xerumenex®). Of this compound, no details can be found. It is probably the same as TEA-oleoyl hydrolyzed collagen (synonyms: TEA-oleoyl hydrolyzed animal protein, triethanolamine oleoyl hydrolyzed animal protein). In the INCI (International Nomencla-ture Cosmetic Ingredients) database of the Personal Care Products Council this material is described as ‘the triethanolamine salt of the condensation product of oleic acid chloride and hydrolyzed collagen’ (https://www.per-sonalcarecouncil.org).
Drug Therapy in Otology
Published in John C Watkinson, Raymond W Clarke, Louise Jayne Clark, Adam J Donne, R James A England, Hisham M Mehanna, Gerald William McGarry, Sean Carrie, Basic Sciences Endocrine Surgery Rhinology, 2018
Many cerumenolytics, including oils and aqueous preparations, are available to soften wax prior to syringing or to disintegrate or disperse the wax, to avoid the need for syringing altogether. Burton and Dorée9 undertook a systematic review and found nine clinical trials. All had a small number of participants, and most were of poor methodological quality. The review concluded that there is insufficient evidence to favour any one particular cerumenolytic. Water and sodium chloride 0.9% seem to be as effective as any proprietary agent. Sodium bicarbonate 5% ear drops, olive or almond oil ear drops are also safe and inexpensive although their effectiveness has not been evaluated in randomized controlled trials. These findings were supported by Clegg et al. in a more recent systematic review.10 If the wax is impacted, these drops can be used twice a day for a few days prior to syringing. Some proprietary preparations contain organic solvents (chlorbutanol, paradichlorobenzene) that may cause irritation to the meatal skin. The rational for inclusion of these ingredients in the preparations is not clear and the vehicle alone is often effective.
Temporary threshold shift following ear canal microsuction
Published in International Journal of Audiology, 2020
A variety of cerumen removal treatments are available in Ear, Nose and Throat (ENT) departments, General Practitioner (GP) surgeries and Audiological clinics. These include cerumenolytics, manual removal, syringing/irrigation and microsuction. Small, non-impacting amounts of cerumen can usually be managed using cerumenolytics or a manual method, such as a Jobson Horne or a curette. Impacted cerumen however can sometimes require a syringing/irrigation or microsuction procedure.