China
Africa
Explore chapters and articles related to this topic
A Strategy for Regeneration of Three-Dimensional (3D) Microtissues in Microcapsules: Aerosol Atomization Technique
Published in Naznin Sultana, Sanchita Bandyopadhyay-Ghosh, Chin Fhong Soon, Tissue Engineering Strategies for Organ Regeneration, 2020
Chin Fhong Soon, Wai Yean Leong, Kian Sek Tee, Mohd Khairul Ahmad, Nafarizal Nayan
Figure 5.12b shows the FTIR spectrum of calcium alginate encapsulated HaCaT cells in the wavelength ranges of 4000-600 cm–1. The broad band at 3274.31 cm–1 exhibited characteristics absorption band for C-H hydroxyl groups in the spectrum of calcium alginate encapsulated HaCaT cells. The FTIR spectrum displays strong phospholipid terminal –CH3 stretching vibrations (both symmetric in the region of 2851.20 cm–1 and asymmetric in the region of 2963.10 cm–1). Then, the dip at 2125.10 cm–1 was caused by –OH stretching. Moving to the fingerprint region, the FTIR spectra exhibited strong Amide II peaking at 1547.30 cm–1. In addition, the bands at 1598.42 cm–1 and 1412.57 cm–1 are assigned to asymmetric and symmetric stretching peaks of carboxylate salt groups of carboxylate and carbonyl (Nagpal et al. 2013). Next, the amide III band and the asymmetric –PO2- stretching vibration were peaking at 1298.20 and 1238.20 cm–1, respectively. The band at 1079.05 and 1029.10 cm–1 (C-O-C stretching) was attributed to its saccharide structure.
Platinum(IV) Anticancer Complexes
Published in Astrid Sigel, Helmut Sigel, Metal Ions in Biological Systems, 2004
Matthew D. Hall, Rachael C. Dolman, Trevor W. Hambley
Another mode of ligand variation is the development of ‘mixed’ axial ligands, which would have intermediate reduction potentials. For example Kizu et al. synthesised /ra^-carboxylatochloro complexes by two routes; by reaction of HCl with the frwis-dicarboxylato ligand to replace a carboxylato ligand with chloride, and reaction of a silver carboxylate salt with the trans-dichloro complex [50]. The silver salt method was found to result in much higher yields, and reduction of the carboxylatochloro species was found to be much faster than the dicarboxylato species. A trans-hydroxomethoxy Pt(IV) complex has been reported, along with the trans-acetatomethoxy Pt(IV) analogue [51].
Comparison of the anticancer effect of microalgal oils and microalgal oil-loaded electrosprayed nanoparticles against PC-3, SHSY-5Y and AGS cell lines
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2021
Benan İnan, Rabia Çakır Koç, Didem Özçimen
As can be seen with FTIR spectrum in Figure 9, bands of hydroxyl, ether and carboxylic functional groups were observed. At 3283 cm−1, the –OH tensile band was formed and the bands seen at 2922–2853 cm−1 had CH antisymmetric and symmetrical stresses. Peaks at 1743 and 1159 cm−1 indicated the presence of oil in the samples. At 1021 and 831 cm−1 there was C–O stress and CH plane deformation. The peak at 1462 cm−1 appeared as asymmetric and symmetrical vibrational stresses of carboxylate salt ions. As can be seen in the spectrum, the peaks of the microalgal oil-loaded nanoparticles and microalgal oil coincided at 2922, 2853, 1743, and 1462 cm−1. This overlap showed the presence of oil in the produced nanoparticles. In the literature, overlaps in the peaks were observed in the various studies that used different oils and polymers for encapsulation researches. Moghaddam et al. studied the production of calcium alginate nanocapsules containing n-nonadecane. When the FTIR spectrum of produced nano capsules and oil was examined, overlaps were observed at 2920 and 2850 cm−1, which was similar to the peaks in this study, and showed that n-nonadecane was successfully encapsulated into the capsules [34]. In another study, the presence of silicone oil in polycaprolactone capsules was observed by FTIR analysis [35].
Clarithromycin laurate salt: physicochemical properties and pharmacokinetics after oral administration in humans
Published in Pharmaceutical Development and Technology, 2019
Bashar A. Alkhalidi, Hatim S. AlKhatib, Mohammad Saleh, Saja Hamed, Yasser Bustanji, Nader Al Bujuq, Naji Najib, Susana Torrado-Susana, Al-Sayed Sallam
FTIR spectroscopy was used to confirm the formation of CLM-L. The FTIR results for the equimolar ratio (Figure 2) showed the appearance of a new peak at 1,559.2 cm−1, which corresponds to the formation of carboxylate salt. This confirms the formation of the salt CLM-L.
Hydroxycamptothecin liposomes based on thermal and magnetic dual-responsive system: preparation, in vitro and in vivo antitumor activity, microdialysis-based tumor pharmacokinetics
Published in Journal of Drug Targeting, 2018
Hai-Mei Zhu, Jin-Hui Gu, Yi Xie, Bo Xie, Jia-Jun Ling
Camptothecin (CPT) is a natural alkaloid first isolated from a Chinese tree Camptotheca acuminata in the 1960s [1,2]. CPT and its derivatives have been shown to have both in vitro and in vivo anticancer activity by inhibiting the DNA-relaxing enzyme topoisomerase I [3]. Among its analogues, hydroxycamptothecin (HCPT) has stronger antitumor activity and less toxic than CPT [4–6]. In China, HCPT is used for treatment of a broad spectrum of cancers [7,8]. HCPT has both carboxylate salt form (C-HCPT) and lactone form (L-HCPT). L-HCPT exhibits more antitumor-active and less toxic due to its lactone form, but is poor in water solubility and tends to be destroyed in blood or water, resulting in inefficient therapeutic effects [4,5]. One way to improve the solubility of L-HCPT is to change the lactone form to the carboxylate form (C-HCPT) by adding NaOH, which is the most common treatment for commercially available hydroxycamptothecin injections in China. However, this leads to less activity and more unwanted toxicity. Based on these situations, the emerging application is to use liposomes as vehicles for L-HCPT delivery [9,10]. The passive targeting mechanism of liposomes makes them inefficient in terms of designing an effective targeting delivery and targeting release system, which is the key for effective cancer treatment. In recent years, the targeting ligands, triggered by external stimuli (i.e. magnetic, hyperthermia and light [11–14]), have been used to achieve effective targeting delivery of oncological drugs in targeted tumour. For example, the thermosensitive magnetic liposomes (TMLs) (magnetic fluid Fe3O4 encapsulated in thermosensitive lipsomes) have been used as drug carriers which can be accumulated in a targeted tumour by an alternating magnetic field [15,16]. Inspired by these results, we designed TMLs that will be delivered and released in response to external heating and external magnetic field, which composed of thermosensitive lipids and oleic acid-modified Fe3O4 magnetic nanoparticles (Fe3O4-OA-MNs). Fe3O4-MNs were modified by sodium oleate in order to change their surface polarities and improve their stabilities when incorporated into thermosensitive liposomes [17,18]. Based on dual-responsive strategy, the targeting delivery of TMLs could be realised with the help of Fe3O4-OA-MNs and external magnetic field, while the thermosensitive release of HCPT/TML in targeted tumour could be realised by the external heating.