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Phytosomes: Preparations, Characterization, and Future Uses
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Palakdeep Kaur, Uttam Kumar Mandal
Demir et al. (2012) prepared photosomes by encapsulating the extracts of C. officinalis and gold nanoparticles using traditional film hydration method. Gold nanoparticles act as anticancer upon living cells and used for wound healing. Calendula officinalis L. has anti-tumoral, pharmacological, anti-inflammatory, antioxidant, and wound healing activities and in 200 cosmetic products in extracted form. The resulting phytosomes were evaluated by atomic force microscopy (AFM), particle size measurement by DLS and surface charge, respectively. The phytosome had high encapsulation efficiency and major constituent of C. officinalis extract (Demir et al., 2014).
Ulcers—Leg/Foot
Published in Charles Theisler, Adjuvant Medical Care, 2023
Calendula: Previous clinical studies demonstrate that applying a calendula ointment (7.5%) to the skin speeds up the healing of leg ulcers caused by poor blood circulation.12 Patients with leg ulcers treated with Calendula officinalis extract had a significant four-fold increase in percentage healing velocity per week.13 Research also indicates that using a calendula spray in addition to standard care and hygiene might prevent infection and decrease odor in people with long-term foot ulcer from diabetes.13
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
On a zero-moisture basis, the seed contains 30.6 to 36.9% protein and 40.8 to 45.8% oil.21 Flowers contain the amorphous calendulin, analogous to bassorin, traces of an essential oil, mucilage, oleanolic acid, a gum, resin, a saponin, a sterol, cholesterol, esters of lauric, myristic, palmitic, stearic, and pentadecylic acids, faradiol, and arnidiol.1 Dry petals contain stigmasterol, sitosterol, 28-isofucosterol, campesterol, 24-methylenecholesterol, and cholesterol, as well as other more complex materials.33 The pigment consists of beta-carotene, lycopene, rubixanthine, violaxanthin, saponins, and phytosterols. Fresh plant material contains the analgesic salicylic acid (0.34 mg/kg). Roots contain inulin.1 According to Tyler, “calendula is apparently non toxic . . . One should not expect any particular therapeutic results from its use, other than those provided by the placebo effect.”37 Rose is even more positive: “It is a plant that causes no allergic reactions, and when mixed with Comfrey and Camomile is extremely useful as an internal or external application for anything. Anyone who is sensitive to plants, especially babies, will benefit from this mixture.”47
Therapy for prevention and treatment of skin ionizing radiation damage: a review
Published in International Journal of Radiation Biology, 2019
José L. Soriano, Ana C. Calpena, Eliana B. Souto, Beatriz Clares
Non-steroidal anti-inflammatories, mainly trolamine, have been proposed by several authors (Table 3), but only one study seems to report real improvement (Abbas and Bensadoun 2012). Similarly, the use of plant derivatives such as Aloe vera or Calendula-based formulations have been inconclusive (Williams et al. 1996; Heggie et al. 2002; Pommier et al. 2004; Sharp et al. 2013), was also observed for sucralfate (Evensen et al. 2001; Wells et al. 2004). The use of Aloe vera is not recommended by the MASCC Skin Toxicity Study Group (Wong et al. 2013) because of lack of efficacy. Other prophylactic agents with topical application are antimicrobials (sulfadiazine), vasoconstrictors (epinephrine), acids (hyaluronic and ascorbic acids), and others agents (miscellaneous). The majority of published work ascertains that there is insufficient evidence to recommend specific topical agents. Indeed, in some cases like Calendula, their use is not recommended (Chan et al. 2012).
Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial
Published in Tissue Barriers, 2022
Giana Silveira Giostri, Eduardo Murilo Novak, Marcelo Buzzi, Luiz Cesar Guarita-Souza
Calendula officinalis L., a plant of the Asteraceae family, popularly known as calendula, is used in several medicinal products and represents an important source of compounds that may serve as new and efficient products for the wound care.9 Extracts obtained from the calendula flower are rich in saponins, flavonoids, sesquiterpenes, alcohol, triterpenoids, hydroxycoumarin, carotenoids, tannin, and essential oils, responsible for the antioxidative, anti-inflammatory, wound healing, antibacterial, antifungal, antiviral, antiedematous and immunomodulating factors.10,11 Faradiol monoesters (triterpenoids) are considered the main active components of the calendula’s anti-inflammatory activity.12 They can induce fibroplasia and angiogenesis and positively contribute to the wound healing processes in vitro and in vivo.13,14 In animal models, the use of Calendula officinalis L. in skin loss presents encouraging results in histopathological analysis of wounds, such as angiogenesis stimulation and increase of hydroxyproline and hexosamine, which impact the formation of collagen and the decrease of epithelization time when compared with the control group.15 Similarly, good results in the use of calendula extracts have been reported in the management of complicated and chronic wounds, such as the ones resulting from venous, pressure and diabetic ulcers, due to its initial anti-inflammatory property and positive interference in the collagen synthesis.9,15,16 Nevertheless, the authors could not identify in the researched studies the use of the calendula extract in clinical trials of traumatic skin loss of the hand and fingers treated with healing by secondary intention. Hence, the question that is raised is whether, according to its potential wound healing properties, Calendula officinalis L. can accelerate the epithelization of acute wounds and promote the prompt return of the functional activities of the hand.
A meta-analysis of preclinical studies using antioxidants for the prevention of cisplatin nephrotoxicity: implications for clinical application
Published in Critical Reviews in Toxicology, 2020
Alfredo G. Casanova, M. Teresa Hernández-Sánchez, Carlos Martínez-Salgado, Ana I. Morales, Laura Vicente-Vicente, Francisco J. López-Hernández
In the present study, 152 articles using antioxidants (single compounds and natural mixtures from the vegetal origin) were meta-analyzed for their capacity to prevent cisplatin nephrotoxicity. Quercetin, Calendula officinalis ethanolic and aqueous floral extracts, curcumin, Heliotropium eichwaldii root methanolic extract, and arjunolic acid were the most effective nephroprotectants (i.e. located most afar from the null effect line in the forest plots). Quercetin is a natural polyphenolic flavonoid abundant in many edible fruits, vegetables, leaves, seeds, and grains. Quercetin’s top position in the efficacy rank is uncertain as large error bars and heterogeneous results between studies are observed (Sanchez-Gonzalez et al. 2011; Verma et al. 2016). Quercetin is a well-known, low toxicity chemical that has advanced to clinical studies for diverse medical applications (Batiha et al. 2020), and amply used as a dietary supplement (Andres et al. 2018). Curcumin is the principal phenolic diarylheptanoid curcuminoid in turmeric rhizomes. Despite showing potential utility in many experimental studies, curcumin has also been described as a pan-assay interference compound with unspecific reactivity and has failed to demonstrate clear-cut beneficial effects in clinical trials (Nelson et al. 2017). Arjunolic acid is a triterpenoid saponin found in the bark of Terminalia arjuna and other plants. Arjunolic acid is a potentially interesting, potent phytochemical with wide pharmacological activity and low toxicity profile in preliminary studies in rats (Aamir et al. 2019), which needs to be further developed at the preclinical and clinical levels. Calendula officinalis is an aromatic species with flavonoid and triterpenoid saponin-rich flowers, with anti-inflammatory properties explored in a variety of conditions (Talhouk et al. 2007; Cravotto et al. 2010). Floral extracts have been tested in clinical trials, mainly for skin conditions and wound healing (Akhtar et al. 2011; Sharifi-Heris et al. 2018; Givol et al. 2019). Finally, Heliotropium eichwaldii is a medicinal plant with hypotensive and antimicrobial properties ascribed to its content in pyrrolizidine alkaloids and flavonoids (Sharma and Goyal 2012).