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Published in Michael J. O’Dowd, The History of Medications for Women, 2020
Marigold (Calendula officinalis) was applied externally, internally and as a fumigation for dysmenorrhea and excess menstrual loss and retains its place for these indications in herbal medicine (BHP, 1983 pp. 44–5; Mclntyre, 1994 p. 95).
Recent Cannabinoid Delivery Systems
Published in Betty Wedman-St Louis, Cannabis as Medicine, 2019
Natascia Bruni, Carlo Della Pepa, Simonetta Oliaro-Bosso, Daniela Gastaldi, Franco Dosio, Enrica Pessione
The same author has more recently published a patent that describes a topical composition made up of an essential combination of synergistically acting phytoactive materials and non-psychotropic phytocannabinoids in combination with a Calendula flower extract (Calendula officinalis L.) and the base formulation to provide anti-inflammation, anti-oxidation, emollient and bactericidal activity [104].
Atlas of Autofluorescence in Plant Pharmaceutical Materials
Published in Victoria Vladimirovna Roshchina, Fluorescence of Living Plant Cells for Phytomedicine Preparations, 2020
Victoria Vladimirovna Roshchina
Pot marigold, Calendula officinalis, is used due to its antibacterial, antiviral, and anti-inflammatory properties (Murav’eva et al. 2007). Their flower baskets and pollen are rich in carotenoids (up to 3% of dry mass) and essential oils (Singh et al. 2011). In Figure 3.6, one can see the fluorescence image and spectra of the petal surface (a and b) and an individual glandular hair (d and e) from a sepal of the ligulate flower. The petal surface includes fluorescing secretory cavities or ducts, seen as the intercellular spaces (possibly filled with essential oils), and they emitted in blue with maximum 450 nm and small shoulder in a range shorter than 440 nm (Figure 3.6, spectra 1 and 2). In contrast, the main surface cells emitted weakly with maximum 550 nm (spectrum 3). This is similar to the known peaks for β-carotene crystals, which fluoresce with peaks at 520–534 nm or with shoulder 500 nm and peak 590 nm in concentrated ethanol solutions (Roshchina 2008). Unlike the base petal cells, the sepal glandular hair emitted in blue, green, and red. Under a confocal microscope, we could see the difference in the emission of capitate top cells of the intact multicellular hair (Figure 3.6, d and e). One of them fluoresced mainly in yellow (spectrum 1) and the second in the blue-green spectral region with a maximum of 475 nm (spectrum 2). In the cells of the stalk (just under tip of the hair), chloroplasts were seen, and chlorophyll brightly emitted in red with maximum 680 nm (spectrum 3). Pollen of the species also fluoresces, mainly in green-orange (Figure 3.6, image g), and the middle part of the pollen grain has a maximum at 530–540 nm, similar to petals (Figure 3.6. image h, spectra 1–4). This peak is specific to β-carotene abundant in the orange petal (Roshchina 2008). Apertures, from which the pollen tube grows, emit more brightly with maximum 520 nm. The petals and pollen of Calendula officinalis contain up to 3% of dry mass of carotenoids such as β-carotene and its oxidized derivatives violoxanthin, flavoxanthin, auroxanthin, and so on (Murav’eva et al. 2007), which may contribute to the fluorescence. Bright green emission may also be due to β-carotene (which is abundant in the orange petals).
Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial
Published in Tissue Barriers, 2022
Giana Silveira Giostri, Eduardo Murilo Novak, Marcelo Buzzi, Luiz Cesar Guarita-Souza
Calendula officinalis L., a plant of the Asteraceae family, popularly known as calendula, is used in several medicinal products and represents an important source of compounds that may serve as new and efficient products for the wound care.9 Extracts obtained from the calendula flower are rich in saponins, flavonoids, sesquiterpenes, alcohol, triterpenoids, hydroxycoumarin, carotenoids, tannin, and essential oils, responsible for the antioxidative, anti-inflammatory, wound healing, antibacterial, antifungal, antiviral, antiedematous and immunomodulating factors.10,11 Faradiol monoesters (triterpenoids) are considered the main active components of the calendula’s anti-inflammatory activity.12 They can induce fibroplasia and angiogenesis and positively contribute to the wound healing processes in vitro and in vivo.13,14 In animal models, the use of Calendula officinalis L. in skin loss presents encouraging results in histopathological analysis of wounds, such as angiogenesis stimulation and increase of hydroxyproline and hexosamine, which impact the formation of collagen and the decrease of epithelization time when compared with the control group.15 Similarly, good results in the use of calendula extracts have been reported in the management of complicated and chronic wounds, such as the ones resulting from venous, pressure and diabetic ulcers, due to its initial anti-inflammatory property and positive interference in the collagen synthesis.9,15,16 Nevertheless, the authors could not identify in the researched studies the use of the calendula extract in clinical trials of traumatic skin loss of the hand and fingers treated with healing by secondary intention. Hence, the question that is raised is whether, according to its potential wound healing properties, Calendula officinalis L. can accelerate the epithelization of acute wounds and promote the prompt return of the functional activities of the hand.
A meta-analysis of preclinical studies using antioxidants for the prevention of cisplatin nephrotoxicity: implications for clinical application
Published in Critical Reviews in Toxicology, 2020
Alfredo G. Casanova, M. Teresa Hernández-Sánchez, Carlos Martínez-Salgado, Ana I. Morales, Laura Vicente-Vicente, Francisco J. López-Hernández
In the present study, 152 articles using antioxidants (single compounds and natural mixtures from the vegetal origin) were meta-analyzed for their capacity to prevent cisplatin nephrotoxicity. Quercetin, Calendula officinalis ethanolic and aqueous floral extracts, curcumin, Heliotropium eichwaldii root methanolic extract, and arjunolic acid were the most effective nephroprotectants (i.e. located most afar from the null effect line in the forest plots). Quercetin is a natural polyphenolic flavonoid abundant in many edible fruits, vegetables, leaves, seeds, and grains. Quercetin’s top position in the efficacy rank is uncertain as large error bars and heterogeneous results between studies are observed (Sanchez-Gonzalez et al. 2011; Verma et al. 2016). Quercetin is a well-known, low toxicity chemical that has advanced to clinical studies for diverse medical applications (Batiha et al. 2020), and amply used as a dietary supplement (Andres et al. 2018). Curcumin is the principal phenolic diarylheptanoid curcuminoid in turmeric rhizomes. Despite showing potential utility in many experimental studies, curcumin has also been described as a pan-assay interference compound with unspecific reactivity and has failed to demonstrate clear-cut beneficial effects in clinical trials (Nelson et al. 2017). Arjunolic acid is a triterpenoid saponin found in the bark of Terminalia arjuna and other plants. Arjunolic acid is a potentially interesting, potent phytochemical with wide pharmacological activity and low toxicity profile in preliminary studies in rats (Aamir et al. 2019), which needs to be further developed at the preclinical and clinical levels. Calendula officinalis is an aromatic species with flavonoid and triterpenoid saponin-rich flowers, with anti-inflammatory properties explored in a variety of conditions (Talhouk et al. 2007; Cravotto et al. 2010). Floral extracts have been tested in clinical trials, mainly for skin conditions and wound healing (Akhtar et al. 2011; Sharifi-Heris et al. 2018; Givol et al. 2019). Finally, Heliotropium eichwaldii is a medicinal plant with hypotensive and antimicrobial properties ascribed to its content in pyrrolizidine alkaloids and flavonoids (Sharma and Goyal 2012).