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Alopecia Areata/Hair Loss
Published in Charles Theisler, Adjuvant Medical Care, 2023
Biotin: Biotin (vitamin B7) administration was found to reverse alopecia in children who had been treated with the anticonvulsant, valproic acid. Although hair loss is a symptom of severe biotin deficiency, there are no published scientific studies that support the claim that high-dose biotin supplements are effective in preventing or treating hair loss in men or women.6,7
Nutritional Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Chelsea Kesty, Madeline Hooper, Erin McClure, Emily Chea, Cynthia Bartus
Clinical presentation: Patients with biotin deficiency may present with periorificial dermatitis, perianal dermatitis, alopecia, brittle nails, and, in severe cases, neurologic dysfunction. Populations at risk for biotin deficiency include infants born with biotinidase deficiency, pregnant and lactating women, and those with chronic alcohol consumption, which can decrease the absorption of dietary biotin. It is frequently used as a supplement for hair and nail growth, but there are limited data to support this.
Mesotherapy: Dutasteride, Minoxidil, Vitamins
Published in Rubina Alves, Ramon Grimalt, Techniques in the Evaluation and Management of Hair Diseases, 2021
David Saceda, Claudia Bernárdez
Due to the high metabolism of hair follicles it has always been considered that vitamins, minerals, and antioxidants are useful, even on healthy hair follicles, to induce better growth. However, this has not been demonstrated. Among the vitamins studied, dexpanthenol (D-panthenol or provitamin B5) would increase keratin-associated protein 4 (KAP4) involved in the terminal keratinization of the hair cortex, hence, giving place to the formation of stronger hair [27]. Biotin (also known as vitamin B7 or H) is very widely used as it is a cofactor of the carboxylase enzymes in multiple metabolic pathways. In addition, it has an important role in the synthesis of proteins. Its role in the production of keratin would explain its contribution to better hair growth [28].
Managing Viral Emerging Infectious Diseases via current Molecular Diagnostics in the Emergency Department: the Tricky Cases
Published in Expert Review of Anti-infective Therapy, 2022
Furthermore, it is required that physicians ask their patients about pregnancy and, particularly, biotin supplements’ consumption, since it is highlighted that biotin causes false test results in immunoassays such as ELISA for laboratory diagnosis of antigens and antibodies, and, also, anti-biotin antibodies can also cause false test results [20]. Additionally, it is evident that a large percentage of populaces is vaccinated against COVID-19 [53]. Hence, infected cases should be asked about their overall vaccination history so as to avoid any false positivity due to vaccine biomolecules or the produced antibodies, since cross-reactions are not impossible, for various viruses and the derived antibodies [20]. Nevertheless, for cases that have received an mRNA-LNP product it seems wise to be tested with PCR assays detecting different genes from it.
Quantification of biotin in plasma samples by column switching liquid chromatography – tandem mass spectrometry
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 2021
Allan Weimann, Peter Plomgaard, Linda M. Hilsted, Henrik E. Poulsen, Emil L. Larsen
Biotin (or Vitamin B7) is a water-soluble vitamin that acts as a coenzyme for multiple carboxylases in several metabolic processes [1,2]. A whole blood biotin concentration below 0.5 nmol/L is considered compatible with deficiency of biotin as measured by the microbiological assay [3]. Acquired biotin deficiency is observed with long-term use of total parenteral nutrition without enough biotin supplementation or prolonged consumption of raw egg whites or chronic anticonvulsant therapy, but it is not a common condition. 1:75,000 children are born with an inherited deficiency of biotinidase, and analysis for mutations in encoding BTD gene is included in screening programs of new-borns. No adverse effects have been reported for up to 300 times the daily recommended intake [4]. Biotin supplementation is widely used, mainly due to proposed beneficial effects on nail and hair growth [5]. Additionally, high dose biotin supplementation has been suggested to delay progression of multiple sclerosis [6]. A recent study questioned the effects of biotin supplementation in patients with multiple sclerosis [7], and currently a large study evaluating high dose biotin supplementation is ongoing (clinicaltrials.gov: NCT03552211).
Effect of perinatal biotin deficiency on auditory pathway of the Wistar-Albino rats
Published in Acta Oto-Laryngologica, 2019
Nevreste Didem Sonbay Yılmaz, Özer Erdem Gür, Nuray Ensari, Erdogan Bulut, Ozlem Tugce Kaya, Serap Sırvancı, Betul Danısman, Narin Derin, Bahri Gezgin, Nurdan Aygener, Mustafa Deniz Yılmaz
Biotin deficiency in adults occurs with an enzyme deficiency that could disrupt the biotin cycle or when there is an increased metabolic need such as in pregnancy and lactation, or in cases of malnutrition. However, the symptoms are generally mild, such as nail disorders and hair loss, and it does not cause neurological symptoms or hearing loss [3]. Biotin is of critical importance in the fetal period in particular when neurological maturation is very rapid, and in the neonatal period. Biotin deficiency in the fetal period leads to severe neurocutaneous symptoms. Studies that have investigated the effect of biotin on hearing loss have generally been conducted on children with very low biotin vitamin levels because of biotidinase enzyme deficiency. However, if there is maternal dietary biotin intake deficiency in these two critical periods, how this affects the auditory pathways of the newborn is not known.