China
Africa
Explore chapters and articles related to this topic
Moringa oleifera (Drumstick)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Furthermore, the synthesis of reactive oxygen species by moringa is precise and attacks only cancer-causing cells, presenting it as the most suitable anticancer agent. Tiloke et al. (2013) also revealed that the extracts enhanced the glutathione-s-transferase expression, decreasing the antioxidant expression. Leaf extracts of moringa have been demonstrated to be anticancer and antioxidant agents which persuade reactive oxygen species. The leaves' constituents held accountable for the anticancer effects are benzyl isothiocyanate, glucosinolates and niazimicin (Hermawan et al., 2012). While benzyl isothiocyanate has been demonstrated to be associated with cancer, data from the research reveals that benzyl isothiocyanate causes reactive oxygen species inside the cells to grow, giving rise to cells' death. This could be among the causes for moringa to act as a fine anticancer herb (Gopalakrishnan et al., 2016).
Sulbentine
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Experimental investigations in patients with sulbentine allergy (number and clinical data unknown) and in guinea pigs suggested that benzyl isothiocyanate is the hapten in cases of sulbentine allergy and is a potent sensitizer (3).
Nutraceuticals’ Role in Proliferation and Prevention of Breast Cancer
Published in Sheeba Varghese Gupta, Yashwant V. Pathak, Advances in Nutraceutical Applications in Cancer, 2019
High intake of fruits and vegetables has shown a possible benefit in the reduction of breast cancer risk. Cruciferous vegetables such a broccoli, cabbage, cauliflower, and Brussel sprouts contain high content of glucosinolates, and when eaten as raw vegetables, or chewed, an enzyme called myrosinase is released that converts glucosinolates into isothiocyanates [22]. This compound is known for its chemoprotective activity in cancer including breast cancer. The isothiocyanates are of different types and act in different ways; for example, benzyl isothiocyanate induced inhibition is associated with apoptotic cell death. The underlying mechanism of isothiocyanates seems to be mainly through the downregulation of ER and their signaling as well as apoptosis and cell cycle arrest, thus preventing the spread of cancer cells.
Effects of Dietary Phytochemicals on DNA Damage in Cancer Cells
Published in Nutrition and Cancer, 2023
Yang Ye, Ying Ma, Mei Kong, Zhihua Wang, Kang Sun, Fang Li
Benzyl isothiocyanate (BITC) is formed by the hydrolysis of glycolaldehyde in cruciferous vegetables such as broccoli and cabbage. BITC exerts anticancer effects by regulating various processes such as apoptosis, autophagy, cell cycle arrest, and angiogenesis (102). It induces G2/M cell cycle arrest and inhibits the proliferation of cells. In a previous study (103), glioblastoma multiforme 8401 cells were treated with BITC; two DNA damage-related genes were identified using complementary DNA chip technology: DNA-damage-inducible transcript three and GADD45A genes. Yeh et al. (23) demonstrated that BITC significantly increases expression of the DNA oxidative damage marker 8-OHDG in human oral cancer OC2 cells and activates the ATM-CHK2-p53 pathway as well as induces G2/M cell cycle arrest and apoptosis. In human pancreatic cancer cells, BITC induces H2AX phosphorylation and inhibits cell proliferation. BITC activates the CHK2 kinase associated with the DNA damage checkpoint and significantly reduces the protein expression of CDC25C, CDC-2, and cyclin B1 (24). Together, these results suggest that BITC inhibits tumor proliferation by regulating DNA damage.
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
Published in Drug Delivery, 2022
Yijin Wang, Qianqian Ouyang, Xuefei Chang, Min Yang, Junpeng He, Yang Tian, Jun Sheng
Seeds from the moringa tree (Moringa oleifera Lam.) contain rich isothiocyanates (MITC) that emerged as highly stable analogues because of the additional sugar moiety present in the aglycone portion of the molecule. Isothiocyanates are organic compounds with a –N═C═S group in their structures (Waterman et al., 2014), To be specific, we used 4-[(α-l-rhamnosyloxy) benzyl] isothiocyanate to complete experiment. The compound is easy to decompose under light or normal temperature. Studies have indicated that MITC exhibit excellent antimicrobial, anti-inflammatory, antioxidant, and antitumor activities (Tumer et al., 2015). Our previous study showed that MITC had an excellent effect on skin photoaging; however, its application in anti-photoaging cosmetics remains limited because of its easy decomposition under light and heat. Further, MITC is a fat-soluble compound with poor water solubility, which leads to low bioavailability. In addition, the effect of the skin barrier hinders the efficient delivery of drugs, thereby making it difficult to predict the transdermal process. In previous studies, the nanodelivery systems of isothiocyanates have been concerned (Wang & Bao, 2021). But researchers have focused more on the development of oral isothiocyanate as an anticancer nanodelivery system. There is little research on the transdermal delivery system of isothiocyanate.
Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Xia Li, Maowei Ni, Xiaoling Xu, Wei Chen
All reagents for enzyme assays, including yGR, recombinant human GR (hGR), bovine serum albumin (BSA), guanidine hydrochloride, ethylenediaminetetraacetic acid (EDTA) and reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) were purchased from Sigma-Aldrich Chemical Co (St. Louis, MO, USA). HPLC grade acetonitrile and trifluoroacetic acid (TFA) were purchased from Tedia Company, Inc (Fairfield, OH, USA). Formic acid was obtained from ROE Scientific Inc (Newark, DE, USA). Foetal bovine serum (FBS), RPMI 1640 growth medium, DMEM growth medium, penicillin/streptomycin, phosphate-buffered saline (PBS) and trypsin were purchased from Gibco (Grand Island, NY, USA). The mass spectrometry grade trypsin was purchase from Promega Corporation (Madison, WI, USA). Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) were obtained from Aladdin (Shanghai, China) and prepared as a 100 mM stock solution in ethanol for all enzyme assays and a 100 mM stock solution in dimethyl sulfoxide (DMSO) for cell-based assay. Other reagents were obtained in their highest purity grade available commercially.