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Nutritional and Dietary Supplementation during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Millions of women used Bendectin during the first trimester of pregnancy with no apparent epidemic of birth defects or adverse fetal effects. Therefore, it seems very unlikely that either doxylamine or pyridoxine is a significant human teratogen. It is generally accepted that neither Bendectin nor its components caused birth defects in human infants. Unfortunately, it does appear that Bendectin was a significant “litogen” (i.e., capable of inducing lawsuits) (Brent, 1983,; Holmes, 1983). A recent paper (Berard et al., 2019) resurrected claims of the possible association of Bendectin components with birth defects, but was quickly followed by a Meta-Analysis (Biffi et al., 2020) that showed no association between Bendectin ingredients and birth defects. The human teratology scientific community does not believe that this combination of drugs (Bendectin) is a cause of birth defects.
Drugs in pregnancy and lactation
Published in Evelyne Jacqz-Aigrain, Imti Choonara, Paediatric Clinical Pharmacology, 2021
Evelyne Jacqz-Aigrain, Imti Choonara
The removal of Bendectin® from the American market despite being safe in pregnancy (see Chapter 4.1) sent a chilling signal to drug companies, essentially discouraging them from studying pregnant patients. Consequently, the advance in therapeutics in pregnancy lags substantially behind the same conditions or drugs in non-pregnant women, or men.
Methodological Issues In Epidemiologic Studies Of Drug Effects
Published in Michele Kiely, Reproductive and Perinatal Epidemiology, 2019
Having defined the etiologic period, the challenge remains to identify the relevant chemicals within drug preparations that are suspected of having adverse effects. These pharmacologic agents may be present in many different drug preparations, both prescribed and over-the-counter. For example, Bendectin, a formerly marketed drug that had been prescribed specifically for treatment of pregnancy-related nausea, contains an antihistamine, doxylamine, that is a common ingredient in nonprescription cold medications. In fact, one of these products contains more doxylamine per recommended dose than the prescription product. In this example, the investigated drug was more likely to have been doxylamine, not merely Bendectin. Pooling of different drug preparations to identify truly exposed people becomes more problematic when an ingredient is contained in many different products. Nearly 100 prescription products contain the vasoconstrictive decongestant, phenylpropanolamine hydrochloride; this chemical is common in over-the-counter preparations that also include aspirin and antihistamine. The prescription products may include codeine. The multiple chemical consistency of many drug preparations causes impurity in the classification of exposure of any single agent.
Interventions for treating nausea and vomiting in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials
Published in Expert Review of Clinical Pharmacology, 2018
Kannan Sridharan, Gowri Sivaramakrishnan
The protocol of this review was registered with PROSPERO with the registration number CRD42017072184. We searched PubMed, Cochrane CENTRAL, and Google Scholar for eligible articles with the following search strategy: (((((morning sickness [tiab] OR nausea [tiab] OR vomiting [tiab] OR hyperemesis [tiab] OR pregnancy [tiab] OR pregnant [tiab] OR Hyperemesis Gravidarum/diet therapy[Mesh] OR Hyperemesis Gravidarum/drug therapy[Mesh])) AND (acupuncture [tiab] OR acupressure [tiab] OR debendox [tiab] OR diclectin [tiab] OR doxinate [tiab] OR dimenhydrinate [tiab] OR peppermint [tiab] OR almond [tiab] OR bendectin [tiab] OR cardamom [tiab] OR diclegis [tiab] OR psychotherapy [tiab] OR lavender [tiab] OR prochlorperazine [tiab] OR dicyclomine [tiab] OR acustimulation [tiab] OR thiethylperazine [tiab] OR mint oil [tiab] OR fluphenazine [tiab] OR chamomile [tiab] OR lemon [tiab] OR hypnosis [tiab] OR trance induction [tiab] OR diazepam [tiab] OR benzodiazepines [tiab] OR phenothiazines [tiab] OR alternative medicine [tiab] ORhydroxyzine [tiab] OR complementary [tiab] OR ginger [tiab] OR garlic [tiab] OR doxylamine [tiab] OR corticosteroids [tiab] OR prednisol* [tiab] OR hydrocort* [tiab] OR ACTH [tiab] OR adrenocorticotrophic hormone [tiab] OR promethazine [tiab] OR anti histamines [tiab] OR antihistamines [tiab] OR anti-histamines [tiab] OR metoclopramide [tiab] OR pyridoxine [tiab] OR vitamin B6 [tiab] OR ondansetron [tiab] OR anti emetic[tiab] OR anti-emetic [tiab] OR antiemetic[tiab] OR dopamine antagonist [tiab] OR serotonergic receptor antagonist [tiab] OR serotonin antagonist [tiab])) AND (randomized [tiab] OR randomised [tiab] OR RCT [tiab] OR clinical trial [tiab]))) NOT review [pt]. No limit was placed with respect to language and studies carried out from 1980 until 2017 were included in the present review. We also hand-searched for appropriate studies from the references listed in the eligible articles.