Barbatic acid

Barbatic acid

Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis

Published in Anton C. de Groot, Monographs in Contact Allergy, 2021

Freshly harvested oakmoss has substantially no scent. The moss contains various types of depsides, which are non-volatile, odorless, polyfunctional diaryl derivatives, including lecanoric acid, evernic acid, divaricatic acid, barbatic acid, atranorin, chloroatranorin and thamnolic acid (see the section ‘Chemical composition’ below). The characteristic oakmoss fragrance is only developed after cleavage of the depsides during treatment of the oakmoss resinoid with alcohols to give volatile, scented, monoaryl derivatives (73). Resorcinol derivatives such as methyl-β-orcinol carboxylate and orcinol monomethyl ether are mainly responsible for the characteristic earthy-moss-like odor of the oakmoss products (74).

Lichenochemicals: extraction, purification, characterization, and application as potential anticancer agents

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Journal Information

Published in Expert Opinion on Drug Discovery, 2020

Mahshid Mohammadi, Vasudeo Zambare, Ladislav Malek, Christine Gottardo, Zacharias Suntres, Lew Christopher

Two lichenochemicals isolated from Roccella montagnei, roccellic acid and evernic acid, exhibited anticancer activity along with inhibition of the cyclic dependent kinase CDK-10 in FaDu head and neck cancer cells [169] (Table 8). The nasopharyngeal squamous cell carcinoma cell line KB was tested with barbatic acid isolated from the lichen Cladonia aggregata. A dose-dependent antineoplastic activity and antiproliferation, with a reported IC50 value of 6.25 μg/ml [159], and a mild synergic interaction in combination with protolichesterinic acid was observed at 20–40 µM concentrations.

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Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis

Lichenochemicals: extraction, purification, characterization, and application as potential anticancer agents