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Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Garden asparagus is the species Asparagus officinalis L. in the family Asparagaceae. It is an herbaceous, perennial plant. Garden asparagus is cultivated for its sprout or shoot, called its spear, which has many specific flavors and nutrients used in cuisine and medicinal purposes (187–191).
Protecting Pancreatic β-cells from Metabolic Insults
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Methanol extract of seeds of Asparagus officinalis L. given to streptozotocin-induced diabetic Wistar rats orally at a dose of 500 mg/kg/day for 28 days for 15 days lowered glycemia from about 8.5 to 5.5 mmol/L and fasting plasma insulin was increased from about 50 to 80 pmol/L.491 The extract improved pancreatic histoarchitecture.491 The potentiality for spirostanol saponins to induce insulin secretion is known. It must be noted that these saponins are anti-inflammatory and as such attenuate streptozotocin pancreatic macrophages stimulation, pro-inflammatory cytokines secretion and favor β-cells regeneration.492 As discussed previously, the stimulation of GPR30 is also possible.
The Ayurvedic Treatment of Neurodegenerative Diseases
Published in Anne George, K. S. Joshy, Mathew Sebastian, Oluwatobi Samuel Oluwafemi, Sabu Thomas, Holistic Approaches to Infectious Diseases, 2017
Of the 300 species of asparagus, Asparagus racemosus (shatavari) has been demonstrated in multiple branches of alternative medicine to have potent medicinal properties. Do not be deceived, but the medicinally active ‘asparagus’ is different than that normally consumed as a popular vegetable in Europe and the Americas. The latter variety is characterized by its long green shoot and is accurately known as Asparagus officinalis. In Sanskrit, shatavari literally means “she who possesses a hundred husbands” as it was traditionally used as an aphrodisiac, especially for females.
An Overview of Hepatocellular Carcinoma with Emphasis on Dietary Products and Herbal Remedies
Published in Nutrition and Cancer, 2022
Deepa S. Mandlik, Satish K. Mandlik
Asparagus (Asparagus officinalis L.) is a common vegetable that can be utilized in a variety of dishes, soups and salads. A. officinalis has been linked to a variety of pharmacological activities, including anti-mutagenicity, anti-inflammation and cytotoxicity, according to several reports. The key constituents responsible for the plant’s bioactivities were proposed to be steroidal saponins, polysaccharides and flavonoids obtained from the plant. Asparagus polysaccharide has been used in the treatment of cancers such as leukemia, breast cancer and lung cancer in clinical trials. According to a review, the asparagus polysaccharide inhibited cell proliferation in HepG2 and Hep3B cells with less toxicity than regular human hepatocellular 7702 cells. The induction of G2/M phase arrest and apoptosis by asparagus polysaccharide through modulation of Bax, Bcl-2, and caspase-3 contributed to the results, according to a mechanistic analysis (58). In a rat model, combining asparagus polysaccharide with transcatheter arterial chemoembolization inhibited the progress of liver tumor and extended survival time while causing minimal toxicity (59). Many cancers, including gastric cancer, oesophagal cancer, leukemia and lung cancer are resistant to Asparanin A (steroidal saponin) obtained from A. officinalis (60). Aasparanin A inhibited HepG2 cells in a dose-dependent manner. Cdk1, Cdk4, and cyclin A were all downregulated, while p21WAF1/Cip1 was upregulated, resulting in G2/M cell cycle arrest. Furthermore, Asparanin A treatment of HepG2 cells promoted apoptosis via both the intrinsic and extrinsic pathways (61).
Protective effect of captopril against diazinon induced nephrotoxicity and neurotoxicity via inhibition of ROS-NO pathway
Published in Drug and Chemical Toxicology, 2018
Milad Vahidirad, Milad Arab-Nozari, Hamidreza Mohammadi, Ehsan Zamani, Fatemeh Shaki
So, compounds with antioxidant properties may be beneficial to prevent oxidative damage of Dz. Previous studies showed the protective role of antioxidant agents against Dz toxicity. For example, aqueous extracts of Matricaria Recutita L. and Asparagus officinalis could ameliorate Dz-induced toxicity through the MDA level reduction and elevation of GSH content (Sulak et al. 2005). Also, pomegranate seed oil reduced Dz-induced nephrotoxicity via inhibition of oxidative stress in the kidney of rats (Boroushaki et al. 2013).