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Annonaceae Species
Published in Atanu Bhattacharjee, Akula Ramakrishna, Magisetty Obulesu, Phytomedicine and Alzheimer’s Disease, 2020
Chistiane Mendes Feitosa, Antônia Laires da Silva Santos, Alyandra de Sousa Nascimento, Veruska Cavalcanti Barros, Valeria Lima Silva Veras, Mahendra Rai
The Annonaceae family comprises approximately 122 genera and about 1100 species. In Brazil, about 30 genera and 260 species are used to relieve or even cure some illnesses. The family consists of trees, shrubs, and rarely, scandic shrubs (Pontes et al., 2004). In the Cerrado, it is represented by several genera and species, many of which are cultivated for their delicious fruits, such as Annona coriacea Mart., Annona crassiflora Mart. and Rollinia emarginata Schl. (Silva et al., 2001), and others as ornamental plants, such as Xylopia aromatica (Lam.) Mart. (Silva-Junior et al., 2005).
In Silico approach of soursop leaf for prediction of anticancer molecular target therapy
Published in Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah, Medical Technology and Environmental Health, 2020
M.K. Dewi, Y. Kharisma, L. Yuniarti
Annona muricata Linn (Annonaceae), commonly known as soursop or graviola, is in the Annonacea family. Some phytochemicals that are reported to have been isolated and characterized from various parts of the soursop plant are annonaceous acetogenins, lactones, isoquinoline alkaloids, tannis, coumarins, procyanidins, flavonoids, pentacyclic terpenoids saponins, p-coumaric acid, myristic acid, stepharine, reticulags, reticulins, ellicags, reticulins, and iced phytosterol (Chen et al. 2012, Liu et al. 2012). The first generation of annonaceous acetogenin mimetic (1, AA005) not only shows antitumor activity in some human cancer cells in vitro but also has high selectivity between normal cells and cancer cells (Qayed et al. 2015, Liang et al. 2009). Flavonoids have cytotoxic effects and selective apoptotic induction activity in vitro on squamous cell carcinoma HSC-2, submandibular gland carcinoma HSG. Tannins have a selective in vitro cytotoxic effect on human T cell lines, human oral squamous cell carcinomas, and salivary gland tumor cell lines rather than normal human gingival fibroblasts with activity inducing apoptosis (Watson & Preedy 2010, Chin 2009).
Phytotherapeutic Agents in Epilepsy
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
The herbal preparations of the root bark of Annona senegalensis Pers. (Fam. Annonaceae) have been employed in Nigerian ethnomedicine for the treatment of epilepsy and febrile seizures. Recently, a bioassay guided fractionation of the root bark extract of A. senegalensis has been carried out using PTZ-induced seizures in mice, affording a diterpenoid, kaur-16-en-19-oic acid (kaurenoic acid) exhibiting potent anticonvulsant effects.64 The postulated mechanism is via the enhancement of central inhibitory mechanisms mediated by GABAA-receptor chloride channel complex.64 Kaurenoic acid has also been isolated from the aerial parts of Espeletia semigloburata Cuatrec. (Compositae) demonstrating potent anticonvulsant and sedative activities.65 There have been other reports on the isolation of kaurenoic acid from the leaves of A. senegalensis66,67 and root extract of Viguiera arenaria Baker (Asteraceae).68
Azadirachtin-based biopesticide affects the respiration and digestion in Anticarsia gemmatalis caterpillars
Published in Toxin Reviews, 2022
Cliver Fernandes Farder-Gomes, Meenakshi Saravanan, Luis Carlos Martínez, Angelica Plata-Rueda, José Cola Zanuncio, José Eduardo Serrão
Although synthetic chemical insecticides are the main strategy to prevent yield losses in agriculture, their indiscriminate use has resulted in ecological, animal, and human health risks, together with the development of insecticide resistance by target insects (Chagnon et al. 2015, Afzal et al. 2015, 2020, Ejaz et al. 2017, Pourya et al. 2020). In a scenario where the contaminant pesticides to the environment and to non-target organisms need mitigation (Isman 2011, Martínez et al. 2015, Zanuncio et al.2016), the search for new biodegradable plant compounds to pest control is important. Plant-derived insecticides have been used as an alternative to synthetic chemical insecticides (Isman 2011, Martínez et al. 2018a, Plata-Rueda et al. 2020a). Advantages of these compounds, including the broad spectrum as insecticides, nonresistance to insect pests, and compatibility with microbial biopesticides (e.g. viruses, bacteria, and fungi) are important in integrating pest programs (Castro et al. 2019, Souza et al. 2019). In this context, biopesticides based on plant compounds from Amarydillaceae, Annonaceae, Lauraceae, Meliaceae, and Poaceae are the most promising for causing detrimental effects on insects (Plata-Rueda et al. 2017, Amaral et al. 2018, Fiaz et al. 2018a, Martínez et al. 2018a, Brügger et al. 2019).
In vitro evaluation of Annona muricata L. (Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells
Published in Biomarkers, 2020
Aditi Venkatesh Naik, Krishnan Sellappan
Annona muricata L. is a flowering plant species within the family Annonaceae; widely found in the world’s tropical and subtropical regions, including parts of Africa, America and Asia (Anuragi et al.2016). All organs of this plant are used as ethnomedicine or phytochemical biomarkers to treat diverse diseases and maladies (Moghadamtousi et al.2015a). The plant components have been thoroughly studied till date for their valuable pharmacological properties, embodied by extracts or isolated compounds and were found most effective in the treatment of cancer along with other ailments (Gavamukulya et al.2017, Qazi et al.2018). According to literature, the leaves of A. muricata contain 117 isolates of secondary metabolites consisting primarily of alkaloids, phenolic compounds, megastigmanes and annonaceous acetogenins (Matsushige et al.2012, Coria-Téllez et al.2018).
Cytotoxic compounds from the leaves and stems of the endemic Thai plant Mitrephora sirikitiae
Published in Pharmaceutical Biology, 2020
Natthinee Anantachoke, Duangporn Lovacharaporn, Vichai Reutrakul, Sylvie Michel, Thomas Gaslonde, Pawinee Piyachaturawat, Kanoknetr Suksen, Samran Prabpai, Narong Nuntasaen
Various natural alkaloids are highly cytotoxic against many cancer cell lines via various different mechanisms of action, and many of these compounds have been developed into anticancer drugs such as vinblastine, vincristine, camptothecin, taxol, and ellipticine (Isah 2016; Iqbal et al. 2017). Liriodenine (5) and oxoputerine (11), aporphine alkaloids, have been reported in many plants of the family Annonaceae. These compounds exhibit cytotoxicity against cancer cell lines A549 (human lung carcinoma), BGC-823 (human gastric carcinoma), BEL-7402 (human liver carcinoma), HTC-8 (human colon carcinoma), and A2780 (human ovarian carcinoma) (Lu et al. 2011). Moreover, the anticancer property of liriodenine (5) is related to its anti-proliferative, apoptosis-inducing (Nakano et al. 2013), and topoisomerase II inhibitory effects (Woo et al. 1999). Liriodenine (5) also arrests the cell cycle by increasing in intracellular nitric oxide (NO) production, the overexpression of apoptosis-related proteins, p53 (Chen et al. 2012) and Bax, and the suppression of Bcl-2 (Nordin et al. 2015). However, there are no reports of the cytotoxicity of 6-methoxymarcanine A (15), a rare natural 1-azaanthraquinone alkaloid. However, it was revealed that marcanine A, a derivative of compound 15, exhibited cytotoxicity against various cancer cell lines A-549, HT-29, MCF-7, RPMI (melanoma), and U251 (human brain carcinoma) (Soonthornchareonnon et al. 1999).