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Ethnomedicinal Plants of North Eastern Himalayan Region of India to Combat Hypertension
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Pintubala Kshetri, K. Tamreihao, Subhra Saikat Roy, Thangjam Surchandra Singh, Susheel Kumar Sharma, Meraj Alam Ansari
Andrographolide is the bioactive phytoconstituent isolated from various parts of Andrographis paniculata. It exhibits anti-HIV, anti-inflammatory, and antineoplastic properties (Chen et al., 2014; Jayakumar, 2013). Yoopan et al. (2007) studied the effects of three active diterpenoids viz., andrographolide (AP1), 14-deoxy-11, 12-didehydroandrographolide (AP3) and neoandrographolide on BP, vascular, and chronotropic responses by using conscious rats and their isolated Arotas as test model. They found that AP3 was most effective for inducing vasorelaxation and retarding heart rate and had a greater hypotensive effect in conscious rats than the AP1. Their result suggests that vascular muscle is the major site of hypotensive effect of AP3. Similarly, Mali et al. (2017) also showed that application of andrographolide loaded scleroglucan based formulation inhaler in rat increased lung deposition of andrographolide powder in lung and pulmonary antihypertensive activity.
Andrographis paniculata (Creat or Green Chiretta) and Bacopa monnieri (Water Hyssop)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Pankaj Mundada, Swati Gurme, Suchita Jadhav, Devashree Patil, Nitin Gore, Sumaiya Shaikh, Abhinav Mali, Suraj Umdale, Mahendra Ahire
Andrographis paniculata has a wide range of medicinal and pharmacological applications (Table 2.1). It has been used in different traditional systems of medicine and exhibits many activities. The important phytochemicals in A. paniculata make the plant useful for treating different ailments and suggest its potential for use in new drugs. The quantitative determination of pharmacognostic parameters will help to set the standards for crude drugs (Joselin and Jeeva, 2014).
Some Plants Used as Phytomedicine by Tribal Healers of Chittagong Hill Tracts, Bangladesh
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Wild Plants, 2020
Khoshnur Jannat, Rownak Jahan, Taufiq Rahman, Shahadat Hossan, Nasrin Akter Shova, Maidul Islam, Mohammed Rahmatullah
Andrographis paniculata is known to contain a number of bio-active compounds, such as andrographolide, 14-deoxy-11-oxo-andrographolide, andrographosterol, andrographosterin, stigmasterol, and α-sitosterol (Bharati et al. 2011). The active anti-malarial compound has been reported to be andrographolide (Mishra et al. 2011). Betacyanins present in Amaranthus spinosus have been shown to possess antiplasmodial activity (Hilou et al. 2006). Clerodendrum viscosum is also rich in antioxidants and other bio-active compounds; these compounds include gallic acid, β-sitosterol, quercetin, oleanolic acid, clerodinin A, β-cubebene, viscosene, apigenin, and clerodolone (Kekuda et al. 2019). Apigenin is known to inhibit the growth of Plasmodium berghei (Amiri et al. 2018).
Herbal and Natural Dietary Products: Upcoming Therapeutic Approach for Prevention and Treatment of Hepatocellular Carcinoma
Published in Nutrition and Cancer, 2021
Deepa S. Mandlik, Satish K. Mandlik
Andrographis paniculata is used in the management of numerous illnesses such as hypertension, inflammations, bacterial and viral infections (42). Andrographolide is the chief di-terpene lactone present in the A. paniculata stems. The treatment of water extract of A. paniculata has been found to improve liver enzyme function and to normalize histopathological alterations in hexachlorocyclohexane-induced malignant liver tissue (43). It demonstrated anti-cancerous effect on cells by causing apoptosis and necrosis of cancer cells. It also strengthens the body's immune response against tumor cells and preventing the proliferation of cancer cells and cell-cycle arrests (44). The A. paniculata ethanolic extract has exhibited a cytotoxic impact on different human cancer cell lines such as HepG2, PC-3, colon 205, and lymphocytic cancer cells (45). The preventive action of andrographolide on cancerous cells might be attributed to their potential to suppress cyclin-dependent kinase and may cause activation of cell cycle inhibitory proteins that obstruct the progression of the cell cycle (46). Andrographolide causes apoptosis induction by various mechanisms such as stimulation of caspase cascade, cytochrome C release from mitochondria and stimulation of proapoptotic protein Bax (47).
Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells
Published in Pharmaceutical Biology, 2021
Jiaqi Lu, Lili Gu, Qin Li, Ningzi Wu, Hongxing Li, Xinyue Zhang
Andrographolide (Andro), present in the medicinal plant Andrographis paniculata (Burm.f.) Nees (Acanthaceae), shows a variety of pharmacological activities including antibacterial (Banerjee et al. 2017), anti-inflammation (Gupta et al. 2020), and immune regulation. Recently it has been found related to the treatment of AD (Cisternas et al. 2019; Xu et al. 2019; Lindsay et al. 2020). Andro can ameliorate the cognitive impairment through the Wnt signalling pathway and glycogen synthase kinase 3β (GSK3β) inactivation, reduce neuro-inflammation and oxidative stress (Seo et al. 2017; Yang et al. 2017), restore the length and function of synapses and stimulate neurogenesis (Varela-Nallar et al. 2015). Our previous study found that Andro could significantly resist Aβ-induced cytotoxicity in PC12 cells and was related to the activation of Nrf2 and p62 (Gu et al. 2018).
Exploring the potential of solid dispersion for improving solubility, dissolution & bioavailability of herbal extracts, enriched fractions, and bioactives
Published in Journal of Microencapsulation, 2021
Debadatta Mohapatra, Ashish K. Agrawal, Alakh N. Sahu
Andrographis paniculata (Family Acanthaceae) is being used to cure liver disorders, fever, common cold, poisoning & upper respiratory tract infection. It also elicits antiviral, antibacterial, anti-HIV, anti-inflammatory, anticancer, and immunostimulatory activities. The bitter diterpenoid lactone “andrographolide” possesses poor aqueous solubility, limited absorption, and bioavailability. SD tablet of the standardised extract was made to avoid the aforementioned limitations. The tablet was found to increase the solubility & in-vitro dissolution of andrographolide compared to neat extract (Nitave et al.2018).