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Apiaceae Plants Growing in the East
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
Sherweit El-Ahmady, Nehal Ibrahim, Nermeen Farag, Sara Gabr
Ammi visnaga L. has been used in folk medicine in the Middle East since ancient times. A decoction of the fruit was used for the treatment of renal colic by the ancient Egyptians, in the treatment of kidney inflammation in Iraq and Palestine, and urolithiasis and prostatic pain in Algeria. The herb extract or plant powder has also been traditionally used for the treatment of abdominal cramps, mild anginal symptoms, as an emmenagogue, diuretic, and has also been prescribed for the amelioration of headaches, vertigo, and diabetes. It was a popular herb used in the treatment of vitiligo and psoriasis. It is generally used to dilate bronchial, urinary, and blood vessels without affecting blood pressure and hence is used for bronchial asthma, urinary calculi and kidney stones. It also has been used as an antidiabetic in Palestine and Morocco (Khalil et al. 2020, Miara et al. 2019). The fruits of Ammi majus were used traditionally for the treatment of skin disorders, psoriasis and vitiligo and was also used as an emmenagogue, as a diuretic, and for treatment of leprosy, kidney stones, and urinary tract infections (Al-Snafi 2013) (Figure 13.5).
Heterocyclic Drugs from Plants
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Debasish Bandyopadhyay, Valeria Garcia, Felipe Gonzalez
Amiodarone (Figure 8.17), also calledNexterone, is an antiarrhythmic medication for arrhythmias, mainly for atrial fibrillation (Amiodarone: Guidelines for Use and Monitoring, 2003). It was extracted from Ammi visnaga (or khella), a flowering plant belongs to the carrot family having the active ingredient khellin (Bhagavathula, 2015). Ammi visnaga is an ancient Egyptian medicinal plant and the tea made from it was being used traditionally to treat several ailments, e.g., asthma, angina, and kidney stone (Bhagavathula, 2015). Khellin (C14H12O5) itself is a vasodilator that also has bronchodilatory activity. Amiodarone regularizes the heart’s electrical impulses (Amiodarone: Guidelines for Use and Monitoring, 2003). Many investigations were reported to validate amiodarone in several arrhythmias. The experiments concluded amiodarone as a safe and efficacious antiar-rhythmic drug (Auer et al., 2002). In comparison to other antiarrhythmic drugs, amiodarone has higher level of tolerance, reduced noncardiac toxicity, and consequently fewer side effects.
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Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Ammi visnaga A plant from the eastern Mediterranean used for centuries to treat asthma. Its active ingredient, khellin, was found to increase coronary blood flow and was tried as treatment for angina in 1936. Sodium cromoglycate, currently used in the prophylactic treatment of asthma, was obtained from its seeds in 1967.
The predictive utility of the plant phylogeny in identifying sources of cardiovascular drugs
Published in Pharmaceutical Biology, 2018
Emily Guzman, Jeanmaire Molina
Experimental studies have repeatedly shown that members of the family Apiaceae work as diuretics. Diuretics increase urine output and lower blood pressure by inhibiting the reabsorption of sodium at different parts of the renal tubular system (Klabunde 2012). Ammi visnaga has been used traditionally in Egypt to treat kidney stones (Vanachayangkul et al. 2010), and has been demonstrated to possess potent diuretic activity due to its bioactive component khellin (Khan et al. 2001; Günaydin and Beyazit 2004). The confamilial Angelica dahurica, an important medicinal plant in the Far East, has also been traditionally used as diuretic (Sarker and Nahar 2004). In celery, Apium graveolens, diuresis due to its constituent, n-butylphthalide, promoted its antihypertensive effect (Moghadam et al. 2013). The crude extract of coriander, Coriandrum sativum, similarly worked as a diuretic in an experiment in rats (Jabeen et al. 2009). In parsley, Petroselinum crispum, phenolic compounds, flavonoids and essential oil components are believed to be responsible for many of its pharmacological activities including its diuretic and antiplatelet activity (Farzaei et al. 2013). Though there were no experimental studies found to support Daucus carota’s (carrot) or Ligusticim wallichii’s use as a diuretic, it is predicted that based on this phylogenetic pattern for Apiaceae, that these species may also promote diuresis.
Randomized crossover study investigating daily versus on-demand vulvar Visnadine spray in women affected by female sexual arousal disorder
Published in Gynecological Endocrinology, 2018
Salvatore Caruso, Diletta Mauro, Maria Cariola, Valentina Fava, Agnese Maria Chiara Rapisarda, Antonio Cianci
Visnadine is an active principle of the fruit of Ammi visnaga, a plant traditionally used in cardiovascular disorders, having peripheral and coronary vasodilator activities, mainly used for the treatment of angina pectoris [10]. Visnadine acts by inhibiting the contractile responses mediated by Ca2+ entry through L-type Ca2+ channels [11,12].