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Migraine
Published in Charles Theisler, Adjuvant Medical Care, 2023
Alpha-Lipoic Acid: In a small RCT, subjects received 600 mg of alpha lipoic (thioctic) acid daily for three months. Within-group analyses also showed a significant reduction in attack frequency, headache days, and headache severity in the treatment group.23
Fatigue
Published in Carolyn Torkelson, Catherine Marienau, Beyond Menopause, 2023
Carolyn Torkelson, Catherine Marienau
Alpha lipoic acid is a nutritional coenzyme that is involved in the metabolism of proteins, carbohydrates, and fats for energy production. It is also necessary to transport glucose from the bloodstream into our body’s cells. In addition, lipoic acid is called the universal antioxidant because it can scavenge a number of free radicals. The cells and tissues in your body are continually threatened by damage caused by toxins from free radicals, reactive oxygen species (which are produced during normal oxygen metabolism), and from the environment. Free radicals, once formed, can disrupt metabolic function and cell structure. Alpha lipoic acid is often added to a mixture of supplements when restoring the body after an illness or when struggling to restore energy. A dose of 100–300 mg per day is typical, but it is best to seek advice from a trained functional medicine practitioner.
Abnormalities of Smell
Published in R James A England, Eamon Shamil, Rajeev Mathew, Manohar Bance, Pavol Surda, Jemy Jose, Omar Hilmi, Adam J Donne, Scott-Brown's Essential Otorhinolaryngology, 2022
Richard L. Doty, Steven M. Bromley
Practicing smelling odours (olfactory training) before and after sleeping may be helpful in returning function, but careful double-blind studies with adequate controls are lacking. There is some evidence to support administration of antioxidants such as alpha-lipoic acid. Spontaneous recovery depends on severity of disturbance. Literature reports that only 11% of anosmic and 23% of microsmic patients regain normal age-related function over time. Olfactory training involves at least four odours of separate categories (typically floral, rose; fruity, lemon; aromatic, eucalyptus and resinous, clove; patients are advised to sniff these for 15 seconds at least twice a day, for up to 6 months.
Alpha lipoic acid as a novel therapeutic approach to cystinuria
Published in Expert Opinion on Orphan Drugs, 2018
Scott V. Wiener, Thomas Chi, Marshall L Stoller
At our institution, we have developed a novel potential therapy, alpha lipoic acid, using a knockout mouse model. This compound has been used in multiple human trials for other disease processes and has been shown to be safe and well tolerated. Furthermore, alpha lipoic acid is classified as a food supplement and is available at a low cost, over the counter, in the United States. The dramatic findings in our mouse model have prompted us to begin a clinical trial despite limited interest from pharmaceutical companies, who have expressed profitability concerns using this generic food supplement. Over the course of this ongoing trial, we will continue to undertake a comprehensive analysis of metabolomic, metallomic, and urine solubility measurements, which will help to elucidate potential predictive biomarkers for stone risk and help to titrate medications.
Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity
Published in Toxicology Mechanisms and Methods, 2022
Heba H. Metwaly, Shadia A. Fathy, Mehrevan M. Abdel Moneim, Manal A. Emam, Ahmed F Soliman, Mehrez E. El-Naggar, Enayat A. Omara, Mona A. El-Bana
Alpha-lipoic acid (α-LA) is a natural disulfide antioxidant found in animal tissues and Vegetables such as broccoli, spinach, and tomatoes: chemically named thioctic acid and 1,2-dithiolane3-pentanoic acid (C8H14O2S2). It is synthesized endogenously in mitochondria from octanoic acid (short‐chain fatty acid) and cysteine as sulfur sources (Mohamed and Meligy 2018). α-LA and its reduced form dihydrolipoic acid (DHLA) have intense neuroprotective effects by preventing neurodegeneration, improving memory retention and cognitive performance, and reversing brain injury by relieving oxidative stress and maintaining cellular redox status (Song et al. 2017). Moreover, it has been proved to possess anti-inflammatory and anti-apoptotic effects (Baluchnejadmojarad et al. 2012).
The time to develop treatments for diabetic neuropathy
Published in Expert Opinion on Investigational Drugs, 2021
There have been large programs to develop new treatments for diabetic neuropathy over the past 50 years. The aldose reductase inhibitors were developed, and many trials have been performed without clear proof of benefit. Only epalrestat has emerged as a possible treatment in Asian countries. There were high hopes for nerve growth factor with initial indications of improvement in the proof of concept trial, only to fade when the confirmatory trial showed no difference from placebo. Ruboxistaurin results were mixed, but were not sufficiently improved over placebo to pursue further development. A four year trial of alpha lipoic acid was inconclusive.