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Dietary Substances Not Required in Human Metabolism
Published in Luke Bucci, Nutrients as Ergogenic Aids for Sports and Exercise, 2020
Guidelines for octacosanol use need further refinement. However, a preliminary suggestion has been made that 1000 to 10,000 μg/d of octacosanol taken over a period greater than 6 weeks may be helpful for sports where reaction time is critical (baseball, football, basketball, hockey, jai-alai, lacrosse, soccer, race car driving). However, actual benefits for sports skills after octacosanol supplementation has not been documented.
Octacosanol and policosanol
Published in Linda M. Castell, Samantha J. Stear (Nottingham), Louise M. Burke, Nutritional Supplements in Sport, Exercise and Health, 2015
Octacosanol (CH3[CH2]26CH2O14), a high-molecular-weight, primary aliphatic alcohol is typically found in the natural wax extract of various plants and is commonly found in fruits, barks, leaves and whole seeds (Singh and Mehta, 2002; Taylor et al., 2005). Octacosanol has been purported to possess several health benefits when ingested as a supplement including lowering cholesterol, cytoprotective effects and antiaggregatory properties (Taylor et al., 2005). The majority of studies that have investigated the effects of octacosanol have used policosanol (wheat-germ oil extract), because it contains a natural mixture of primary alcohols isolated from sugar cane wax, and octacosanol is the main component of policosanol (Kato et al., 1995; Saint-John and McNaughton, 1986).
Nutritional Ergogenic Aids: Introduction, Definitions and Regulatory Issues
Published in Ira Wolinsky, Judy A. Driskell, Nutritional Ergogenic Aids, 2004
Ira Wolinsky, Judy A. Driskell
Octacosanol, a long-carbon-chain alcohol, is the primary active component of wheat germ oil. Small quantities of octacosanol are available from dietary plant waxes, leaves, skins and seeds. Wheat germ oil, rather than octa-cosanol, is the form generally used as a dietary supplement. Research studies have indicated that octocosanol or wheat germ oil supplementation seems to be a promising lipid-lowering agent, especially in lowering cholesterol and platelet antiaggregation. Wheat germ oil ingestion is claimed to enhance physical performance and delay fatigue. Unfortunately, well controlled research studies on wheat germ oil as an ergogenic aid are not available. Few side effects have been reported from ingestion of wheat germ oil or octacosanol supplements.
The Beneficial Radioprotective Effect of Tomato Seed Oil Against Gamma Radiation–Induced Damage in Male Rats
Published in Journal of Dietary Supplements, 2018
Magda K. Ezz, Nashwa K. Ibrahim, Mahmoud M. Said, Mostafa A. Farrag
The subchronic pretreatment of rats with TSO suppressed gamma radiation–induced systemic inflammation in the current study, as revealed by the significant reduction in the level of serum VCAM-1. Among the isolated TSO policosanol are tetracosanol, hexacosanol, and octacosanol (Giuffrè and Capocasale, 2015). Fernández-Arche et al. (2009) demonstrated the anti-inflammatory potential of tetracosanol, hexacosanol, and octacosanol isolated from pomace olive oil (POO) to reduce the release of different inflammatory mediators (tumor necrosis factor-α, prostaglandin E2, and nitric oxide) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. Furthermore, the anti-inflammatory potential of TSO is in part attributed to its lycopene content, which is reported to reduce zearalenone-induced toxicity and inflammation in mice and to improve cellular antioxidant potential (Boeira et al., 2015). Lycopene also protected cultured human umbilical vein endothelial cells (HUVECs) against lipopolysaccharide-induced acute inflammation, demonstrating therefore an anti-inflammatory role (Wang et al., 2013).
Superior anti-neoplastic activities of triacontanol-PEG conjugate: synthesis, characterization and biological evaluations
Published in Drug Delivery, 2018
Yimeng Zhou, Ning Li, Zhixia Qiu, Xiaoyu Lu, Min Fang, Xijing Chen, Lili Ren, Guangji Wang, Pingkai Ouyang
As reported, octacosanol could effectively inhibit the proliferation of endothelial cells and ascites cancer cells, suppress angiogenesis and secretion of cancerous ascites, which were largely pertinent to the inhibition of NF-κB translocation. TA, as a homolog of octacosanol, may also exert tumor killing through a similar mechanism. Therefore, it was necessary to investigate the anti-tumor activity of PEGylated TA and its possible mechanism.