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Comparative Anatomy, Physiology, and Biochemistry of Mammalian Skin
Published in David W. Hobson, Dermal and Ocular Toxicology, 2020
A shave biopsy is done when lesions or damage is suspected to be very superficial. After the administration of a local anesthetic, a fold of skin is lifted and a scalpel is used to cut through the skin surface.1–4
Biopsy of the nail unit
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Sushil Tahiliani, Harsh Tahiliani
Alternatively, a shave biopsy can be performed by the razor blade technique. A razor blade is broken into two longitudinal halves. One half is held between the thumb and index finger to slice out the proximal nail fold.1
Vulvar procedures
Published in Miranda A. Farage, Howard I. Maibach, The Vulva, 2017
Allison Jackson, Danielle Cooper, E. J. Mayeaux
Shave biopsy is used to obtain partial-thickness tissue for histologic examination and is useful for removing superficial lesions in their entirety. Pedunculated lesions above the skin surface are particularly well suited for shave excision, but other types of lesions that are not deep in the dermis can be removed by shave technique (14). Shave procedures are quick, require little training, and do not require sutures for closure. A small, slightly depressed scar about the size of the initial lesion often results (15).
Sweet syndrome and erythema nodosum in a young patient with ulcerative colitis
Published in Baylor University Medical Center Proceedings, 2023
Katherine Gonzalez, Janice Thomas, John Givler, Lindsey Stockton
On admission, the patient was started on methylprednisolone sodium succinate 81.25 mg intravenously every 8 hours. Gastroenterology was consulted for her UC flare and recommended the intravenous steroids be reduced to 40 mg every 8 hours. Infectious disease started the patient on vancomycin 750 mg intravenously every 8 hours. To rule out infectious causes of rash, Cryptococcus antigen, Histoplasma antigen, Blastomyces dermatitidis antibody, varicella zoster IgG serology, fungal culture, blood culture, and methicillin-resistant Staphylococcus aureus (MRSA) culture were ordered and came back negative. After MRSA came back negative, vancomycin was discontinued. Dermatology conducted a shave biopsy on a small subcentimeter lesion on the back. The epidermis showed a small erosion, mild spongiosis with exocytosis of a few neutrophils. The dermis was extensively infiltrated with numerous neutrophils with significant leukocytoclasis, consistent with SS. No overt vasculitis or ulceration was noted.
BAPoma presenting as an incidental scalp papule: case report, literature review, and screening recommendations for BAP1 tumor predisposition syndrome
Published in Journal of Dermatological Treatment, 2022
Marcus Zaayman, Peter Nguyen, Annika Silfvast-Kaiser, Jillian Frieder, Cameron West, Katherine Tumminello, So Yeon Paek
A 51-year-old female presented to the dermatology clinic for follow up regarding hidradenitis suppurativa (HS). At this visit, the patient also noted a firm, translucent papule to her left frontal hairline (Figure 1). Past medical history was significant only for HS. A shave biopsy of the skin lesion was performed (Figure 2). Histopathologic evaluation was consistent with a BAP1-inactivated spitzoid tumor (‘BAPoma’), revealing a circumscribed intradermal proliferation of melanocytes, with enlarged vesicular nuclei, rare mitoses superficially, no junctional component, and patchy lymphocytic infiltrate in the dermis. Nuclear BAP1 staining was absent. Upon histopathologic diagnosis, a thorough family history was obtained which revealed a history of metastatic ocular melanoma in the patient’s father, brother, and paternal grandmother (PGM). Her brother had also had multiple atypical melanocytic lesions excised. All of her PGM’s siblings had been affected with various cancers, although specifics could not be recalled. This case was discussed at our Multidisciplinary Skin Tumor Board at which time genetic counseling, ophthalmology consultation, total body skin examination, and complete excision of the BIMT was recommended. At the time of manuscript submission, no further updates were available, as the patient was hindered from obtaining further work-up due to loss of health insurance.
Revisiting techniques to evaluate drug permeation through skin
Published in Expert Opinion on Drug Delivery, 2021
Vamshi Krishna Rapalli, Arisha Mahmood, Tejashree Waghule, Srividya Gorantla, Sunil Kumar Dubey, Amit Alexander, Gautam Singhvi
Skin biopsy is an invasive technique that is performed under the effect of local anesthesia. Drug content estimation from biopsy samples provides information on total drug concentrations, i.e. free, bound, and vascular concentrations. Since it does not yield direct information of the unbound concentration, the results are difficult to interpret. On the one hand, the technique underestimates the concentration of those drugs that rapidly equilibrate with the extracellular fluid such as β-lactam antibiotics and, on the other hand, overestimates the concentration of drugs that accumulate in the intercellular fluid, such as quinolone antibiotics or macrolides. Skin biopsy includes two types, shave biopsy (which is restricted to the dermis only) and punch biopsy (reaching subcutaneous tissue level). Due to obvious reasons for being tedious and time-consuming, skin biopsy techniques are not used for routine tissue sampling and in vivo analysis. Although skin biopsy gives a clear image of drug deposition in various subsections of skin, due to its degree of invasiveness, it is only employed during in vivo animal experimentation [42,47].