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Immunopathology of Myasthenia Gravis
Published in Marc H. De Baets, Hans J.G.H. Oosterhuis, Myasthenia Gravis, 2019
The presence of multiple auto-antibodies merely reflects a dy sregulation of the immune system. Auto-antibodies with multiple autoreactivities have been demonstrated in normal individuals. This “natural” activation of autoreactive B cells occurs in a network of idiotypically interconnected antibodies already present neonatally.144 Disturbances in this network may result in pathological autoimmune reactions. Viral or bacterial antigens may play a role in the disturbance of this idiotype network through molecular mimicry, i.e., cross-reactivity between viral or bacterial antigens and the acetylcholine receptor. About 20% of MG patients have antibodies against ʅ1,3-dextran (DEX) an antigenic determinant present on certain bacteria including enterobacter cloacae and Serratia liquefaciens.145 Anti-DEX antibodies and anti-idiotypes against anti-AChR antibodies are idiotypically connected. Administration of anti-DEX monoclonal antibodies to mice can alter the immune response to AChR.146 The a-subunit of AChR shares determinants with gram negative bacteria including E coli.147 Several viral antigens, including retrovirus, rabies virus, and adenovirus, have been implicated in the pathogenesis of MG.148
Identification of clinical specimens isolated from neonates
Published in Elida Zairina, Junaidi Khotib, Chrismawan Ardianto, Syed Azhar Syed Sulaiman, Charles D. Sands, Timothy E. Welty, Unity in Diversity and the Standardisation of Clinical Pharmacy Services, 2017
M. Djunaedi, S.A.S. Sulaiman, A. Sarriff, N.B.A. Aziz, Habsah
The common Gram-negative bacteria isolated in 2003 and 2004 included Enterobacter sp. (26% and 5%), Klebsiella pneumoniae (23% and 47%), Acinetobacter sp. (14% and 12%), Pseudomonas aeruginosa (13% and 13%), and Escherichia coli (8% and 6%, respectively). The other Gram-negative bacteria are Citrobacter sp., Burkholderia pseudomallei, Serratia rubidaea, Haemophilus parainfluenzae, Pseudomonas putida, Serratia marcescens, Pantoea (Enterobacter) agglomerans, Comamonas testosteroni, Stenotrophomonas (Xantho) maltophilia, Pantoea sp., Proteus vulgaris, Burkholderia (Pseudo.) cepacia, Salmonella sp., Serratia ficaria, Escherichia vulneris, Serratia liquefaciens, enteropathogenic bacteria, Acinetobacter baumannii (anitratus), Alcaligenes xylosoxidans ss. xyloso, and Acinetobacter lwoffii.
Published in Ronald M. Atlas, James W. Snyder, Handbook Of Media for Clinical Microbiology, 2006
Ronald M. Atlas, James W. Snyder
Use: For the cultivation and differentiation of Serratia species based on the fermentation of arabinose and production of ornithine decarboxylase. Serratia marce-scens changes the medium to purple throughout the tube. Serratia liquefaciens changes the medium to a band of purple at the top of the tube with a green/yellow butt. Serratia rubidaea changes the medium to yellow throughout the tube.
Good microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome
Published in Gut Microbes, 2022
Alexander Crits-Christoph, Haley Anne Hallowell, Kalia Koutouvalis, Jotham Suez
Both experimental and clinical evidence have firmly established that ARGs can be horizontally transferred between microbes in vivo. In experimental settings, spreading of ARGs via HGT between members of the Enterobacterales appears particularly frequent. While Enterobacterales are generally a minority in the healthy gut, in an inflamed state they can bloom in abundance and engage in highly frequent HGT.7 HGT of ARG plasmids between Klebsiella pneumoniae and E. coli has been observed in clinical cases.33,34 Another clinical example identified three Enterobacterales (E. coli, K. pneumoniae, and Enterobacter cloacae) co-infecting a patient that all possessed a blaOXA-48-harboring IncL/M-type plasmid, hinting that the plasmid had been acquired by two of the strains while within the patient’s gut microbiome.35 Conjugation of an ARG plasmid between E. coli strains has also been observed in the infant gut36 and in a human challenge experiment.37 Even in the absence of any antibiotic selective pressure, Serratia liquefaciens was observed transferring a plasmid with extensive ARGs to E. coli within the mouse gut.38 Additionally, post-antibiotic persisters of Salmonella enterica were found to easily transfer resistance plasmids to E. coli in the murine gut.39
2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms
Published in Biofouling, 2021
Lene Jacobs, Jolien Meesters, Ilse Parijs, Geert Hooyberghs, Erik V. Van der Eycken, Bram Lories, Hans P. Steenackers
The 2-aminoimidazole imi-AAC-5 has been tested before, mainly on mono-species biofilms. Specifically, Steenackers et al. (2011) first demonstrated the high anti-biofilm activity of imi-AAC-5 (compound 119 in Steenackers et al. 2011) against the pathogens Salmonella Typhimurium and Pseudomonas aeruginosa with a 50% inhibition concentration (IC50) of 4.4 µM and 13.5 µM, respectively. No inhibition in planktonic growth was observed at the concentrations tested (Steenackers et al. 2011). In addition, activities against Escherichia coli, Porphyromonas gingivalis, Serratia liquefaciens and Candida albicans were reported. However, some, mainly Gram-positive, bacterial strains are inherently more tolerant to imi-AAC-5, demonstrating strain dependency (Peeters et al. 2016). Importantly, imi-AAC-5 was shown to select against resistance during a 40-day evolutionary experiment in S. Typhimurium biofilms, indicating that this compound is more robust to resistance development than conventional antimicrobials (Dieltjens et al. 2020).
Phenolic extract of Eugenia uniflora L. and furanone reduce biofilm formation by Serratia liquefaciens and increase its susceptibility to antimicrobials
Published in Biofouling, 2020
Adeline Conceição Rodrigues, Felipe Alves de Almeida, Cleriane André, Maria Cristina Dantas Vanetti, Uelinton Manoel Pinto, Neuza Mariko Aymoto Hassimotto, Érica Nascif Rufino Vieira, Nélio José de Andrade
The genus Serratia comprises bacteria in the form of Gram-negative rods of the family Enterobacteriaceae, being frequently encountered in nosocomial infections (Arslan et al. 2010; Remuzgo-Martínez et al. 2015; Srinivasan et al. 2016) and spoiled foods (Macé et al. 2013; Säde et al. 2013; Machado et al. 2015, 2016; Fougy et al. 2016). Serratia liquefaciens is one of the most abundant psychrotrophic microorganisms in cold raw milk and a producer of thermoresistant deterioration enzymes in milk and dairy products, such as proteases and lipases (Cleto et al. 2012; Machado et al. 2015, 2016; Baglinière et al. 2017a, 2017b; Salgado et al. 2020). In addition, different strains of S. liquefaciens isolated from milk and milk processing plants form biofilms and produce spoilage enzymes (Cleto et al. 2012; Teh et al. 2012).