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Liver Diseases
Published in George Feuer, Felix A. de la Iglesia, Molecular Biochemistry of Human Disease, 2020
George Feuer, Felix A. de la Iglesia
Excess drinking of alcoholic beverages over a long period combined with poor food intake is followed by various liver diseases in many people.100,181,525 Among these conditions alcoholic hepatitis is fairly common with frequency of about one in ten alcoholics. Alcoholic hepatitis is a morphological entity characterized by an inflammatory reaction of polymorphonuclear leukocytes and hepatocellular necrosis.406 The lesions are mainly localized in the centrolobular area, but in more severe cases it may be more diffuse across the liver lobule. Irregular clumps of hyalin, so-called Mallory bodies, may be present in damaged cells. The severity of the lesions is usually associated with the presence of Mallory bodies.197 Similar structures have been, however, described in hepatocytes in other conditions such as primary biliary cirrhosis,380 hepatocellular carcinoma,304 following griseofulvin treatment,123 and in patients who had bypass operations for morbid obesity.238
A Histopathologic Classification of Chemical-Induced Injury of the Liver
Published in Robert G. Meeks, Steadman D. Harrison, Richard J. Bull, Hepatotoxicology, 2020
John M. Cullen, Boris H. Ruebner
Mallory bodies are eosinophilic cytoplasmic inclusions by light microscopy and represent a proliferation of intermediate-type filaments. They were first described as a response of the hepatocyte to chronic ethanol ingestion (Lieber, 1975). However, we know now that Mallory bodies are a reaction which may be seen in a variety of different types of injury. Among these are cholestatic conditions in humans such as Wilson’s disease, primarily biliary cirrhosis, and Indian childhood cirrhosis. Griseofulvin in rats (Denk et al., 1975) and Dieldrin in mice (Meirhenri et al., 1981) have also been found to produce these structures.
Hepatic Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Histologically, HCC is typically a well-vascularized tumor with wide trabeculae (more than three cells), prominent acinar pattern, small cell changes, cytologic atypia, mitotic activity, vascular invasion, absence of Kupffer cells, and the loss of the reticulin network. The common histologic growth patterns of HCC range from trabecular-resembling normal liver tissue, pseudoglandular or acinar with possible bile or fibrin content, and solid or compact pattern. The tumor cells often show Mallory bodies and pale bodies [5].
Thiamin Regresses the Anticancer Efficacy of Methotrexate in the Amelioration of Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Wistar Strain Rats
Published in Nutrition and Cancer, 2020
Shakir Saleem, Imran Kazmi, Aftab Ahmad, Mohammed F. Abuzinadah, Ali Samkari, Huda M. Alkrathy, Ruqaiyah Khan
The histopathological slides were prepared and observed under light microscope. In the NC group normal hepatic architecture with distinct central vein (CV) and normal hepatocytes radiating outward from the CV with regular sinusoids were clearly seen (Fig. 5A). Contrastingly, in the DC group the induction of HCC was characterized by the presence of large cells with prominent hyper-basophilic preneoplastic focal lesions (b) and the presence of eosinophilic cytoplasm, large nuclei and cytoplasmic Mallory bodies (M). Compact growth pattern and degeneration of hepatocytes (black arrow) was also noted along with micro-trabecular growth patterns and with cords of tumor cells distanced by sinusoidal voids (T) (Fig. 5B). In the DM group, ballooning degeneration (B) and reparative changes in hepatocytes (R) was witnessed, however, congestion of cells around CV and sinusoidal irregularities were also spotted (Fig. 5C). Summing up these observations implies the alleviation of cancerous condition of liver by MTX. Oppositely, in the DT group, pleomorphic changes (P), irregular sinusoids (IS), and micro-trabecular growth patterns (T) (Fig. 5D) was clearly seen, which suggests the gradual degradation in HCC condition in DT group. Irregular sinusoids (IS), trabeculae of malignant cells (arrow), and microtrabecular growth patterns, with cords of tumor cells distanced by sinusoidal voids (T) was noted in the DMT group (Fig. 5E), which was like a transitional state between DM and DT groups. The histopathological revelations suggest the possible interference of thiamin in the therapeutic effect of methotrexate (MTX).