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A Treatise on the Role of Herpesvirus in Neurodegeneration
Published in Abhai Kumar, Debasis Bagchi, Antioxidants and Functional Foods for Neurodegenerative Disorders, 2021
Bernard W. Downs, Manashi Bagchi, Bruce S. Morrison, Jeffrey Galvin, Steve Kushner, Debasis Bagchi, Kenneth Blum
Each of the members of the “family” of herpesviruses consists of more than 30 different virally encoded proteins that also contain cellular components, making the herpesvirus possibly the most complex of viral structures [48]. Nine herpesvirus types are known to infect humans: HSV-1 and HSV-2, VZV, EBV or HHV-4, human cytomegalovirus, human herpesvirus 6A and 6B (HHV-6A and HHV-6B), human herpesvirus 7 (HHV-7), and Kaposi’s sarcoma-associated herpesvirus (KSHV, also known as HHV-8) [49].
Infection in the Hematopoeitic Stem Cell Transplant Recipient with Autoimmune Disease
Published in Richard K. Burt, Alberto M. Marmont, Stem Cell Therapy for Autoimmune Disease, 2019
Valentina Stosor, Teresa R. Zembower
Due to the defects in T lymphocytes, interferon production, and NK cell number and function, herpes zoster infection is the leading viral opportunistic infection in SLE patients.38 In contrast, cytomegalovirus (CMV) infections are not common in this population. One reason may be that CMV infection requires a more advanced level of immunosuppression similar to that found in AIDS patients with very low CD4+ lymphocytes. Nevertheless, CMV pneumonia, vasculitis, and disseminated disease have all occurred in patients with SLE.31,39 Retinitis caused by human herpesvirus-7 has been described in a 14-year old SLE patient.40
Principles of Clinical Diagnosis
Published in Susan Bayliss Mallory, Alanna Bree, Peggy Chern, Illustrated Manual of Pediatric Dermatology, 2005
Susan Bayliss Mallory, Alanna Bree, Peggy Chern
Watanabe T, Kawamura T, Jacob SE, et al. Pityriasis rosea is associated with systemic active infection with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol 2002; 119: 793–7 Pityriasis lichenoides
Anterior Uveitis Associated with Human Herpesvirus 7 Infection Diagnosed by Multiplex Polymerase Chain Reaction Assay: A Case Report
Published in Ocular Immunology and Inflammation, 2023
Shintaro Shirahama, Rie Tanaka, Toshikatsu Kaburaki
Human herpesvirus 7 (HHV-7) is a double-stranded DNA virus, which belongs to the subfamily of β-herpesviruses.1 In children, HHV-7 is one of the pathogens that causes roseola.2 Furthermore, in adults, HHV-7 causes encephalitis,3,4 and HHV-7 DNA can be detected in the blood and cerebrospinal fluid of patients after organ transplantation.5 Over 90% of adults have antibodies to this virus, which causes a latent infection in the body.6 However, to the best of our knowledge, there has only been one published report of ocular manifestation related to HHV-7.7 In that report, the patient presented with corneal endotheliitis, and HHV-7 DNA was detected in a sample from the aqueous humor.7 A previous report showed that HHV-7 DNA was not detected in the intraocular samples of 500 patients with uveitis and endophthalmitis.8 Furthermore, in another report, HHV-7 DNA was not detected in the vitreous fluid of 101 patients, including 69 samples from patients with ocular inflammation.9 Thus, ocular inflammation associated with HHV-7 is considered to be quite rare. In this report, we present the case of a patient with HHV-7-related anterior uveitis (AU) with a high copy number of HHV-7 DNA in the aqueous humor, which was detected using a polymerase chain reaction (PCR) assay.
Pityriasis rosea-like eruption induced by isotretinoin
Published in Cutaneous and Ocular Toxicology, 2018
Gülhan Gürel, Sevinç Şahin, Emine Çölgeçen
Pityriasis rosea (PR) is a common, self-limited and inflammatory skin disease1. The incidence of PR is 0.5–2% and it is more common in the 15–30 age group2. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors for PR3. Regarding etiology of PR, many studies established a causal role for systemic active HHV-6 (Human herpesvirus-6) and HHV-7 (Human herpesvirus-7) infection in the pathogenesis of PR, based on the detection of HHV-6 and HHV-7 DNA in plasma, HHV-6 and HHV-7 mRNA expression and specific antigens in skin lesions of PR patients4–6. In addition, herpes virus virions in various stages of morphogenesis were detected by electron microscopy in skin lesions and in the supernatant of co-cultured peripheral blood mononuclear cells (PBMCs) from PR patients7,8.
Longitudinal study on oral shedding of human betaherpesviruses 6 and 7 in renal transplant recipients reveals active replication
Published in Journal of Oral Microbiology, 2020
Jéssica Vasques Raposo, Dmitry José De Santana Sarmento, Rafaela Barbosa Da Silva Pinto, Amanda Oliveira Lopes, Marina Gallottini, Tânia Regina Tozetto-Mendoza, Paulo Henrique Braz-Silva, Vanessa Salete de Paula
Human herpesvirus 6 (HHV-6A/B) and human herpesvirus 7 (HHV-7) belong to the genus Roseolovirus and subfamily Betaherpesvirinae. Although CD4 + T lymphocytes have been identified as the preferred replication site, HHV-6 is characterized by widespread tropism in multiple human cell types and classified into two closely related variant groups, HHV-6A and HHV-6B, which are currently recognized as distinct herpesvirus species. HHV-6B is reported as the major causative agent of sudden rash while no clear association with HHV-6A has been established [1].