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Sulfonamides
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Natasha E. Holmes, M. Lindsay Grayson
At a concentration of 10 μg/ml, SSD inhibits herpes simplex virus types 1 and 2 in vitro (Chang and Weinstein, 1975b) and prevents acute herpetic keratoconjunctivitis in rabbits (Chang and Weinstein, 1975c). SSD also has activity against Treponema pallidum (Chang and Weinstein, 1975a), but this has little clinical relevance.
The ocular surface, coronaviruses and COVID‐19
Published in Clinical and Experimental Optometry, 2020
Mark Dp Willcox, Karen Walsh, Jason J Nichols, Philip B Morgan, Lyndon W Jones
There has been one report of a woman who presented with rhinorrhoea, cough, nasal congestion, unilateral conjunctivitis, but no fever (although the subject had taken over‐the‐counter antipyretic medication) as the initial presentation of COVID‐19.52 The case history indicates that the patient had returned from a vacation in the Philippines and had transited through San Francisco on her return to Canada. She had swum in the sea and hotel swimming pools on vacation, and a public swimming pool once on her return to Canada. Upon presentation to an ophthalmology clinic she was initially diagnosed with presumed herpetic keratoconjunctivitis, which was subsequently changed to presumed epidemic keratoconjunctivitis after initial antiviral medications did not appear to be affecting the disease. The conjunctivitis remained unilateral during the seven days of the investigation.
Boston-keratoprosthesis for Idiopathic Limbal Stem Cell Deficiency
Published in Ocular Immunology and Inflammation, 2018
Ashik Mohamed, Ritu Shah, Virender S. Sangwan
Based on the clinical history and ocular features, a diagnosis of bilateral idiopathic LSCD (OD – partial LSCD with double pterygium and OS – total LSCD) was made. LSCD can be primary due to congenital causes, such as aniridia, sclerocornea, ectodermal dysplasia, multiple endocrine neoplasia, etc. or else it can be secondary due to direct stem cell loss, post-chemical injury, post-autoimmune conditions, such as ocular cicatricial pemphigoid, non-autoimmune disorders such as vernal keratoconjunctivitis, atopy, post-herpetic keratoconjunctivitis, iatrogenic such as post-surgery for pterygium or ocular surface squamous neoplasia, etc. However, our patient had no such history except for persistent redness in left eye, for which we kept a differential diagnosis of herpetic keratitis. The pattern of the conjunctivalization affecting both eyes could be that of an aniridic keratopathy with subtle changes in fovea and iris and absence of nystagmus.3
In Vivo confocal microscopy findings after COVID-19 infection
Published in Ocular Immunology and Inflammation, 2022
Mehmet Serhat Mangan, Ayse Yildiz-Tas, Merve Beyza Yildiz, Elvin Yildiz, Afsun Sahin
A decrease in corneal sensation in unilateral conjunctivitis classically points to herpetic corneal disease.10–14 Herpetic keratoconjunctivitis was also included in the differential diagnosis of our patient due to the unilateral conjunctival hyperemia and corneal involvement. IVCM shows significant involvement of the subepithelial nerve plexus in the epithelial and stromal keratitis forms of herpes,10–14 as it did in our case. However, the multiple subepithelial infiltrates that were observed in our case are not commonly encountered in herpes simplex keratitis. Our patient also had no previous history of ocular herpes and the typical dendritic lesion of herpetic epithelial keratitis was not observed.