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The locomotor system
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
The clinical history in nodular fasciitis is usually of a rapidly growing tender nodule in the upper limb, especially the forearm of a young adult. Most often the lesion is subcutaneous, but sometimes muscle or deep fascia is involved. Microscopy shows fibroblasts randomly arranged like cells in tissue culture, with frequent mitotic figures of normal morphology (Figure 13.45). There is a prominent vascular pattern with scattered chronic inflammatory cells. This entirely benign lesion must not be misdiagnosed as a sarcoma.
Skin and soft tissue
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
Nodular fasciitis is a benign subcutaneous tumour due to reactive proliferation of fibroblasts. Lesions consist of spindle-shaped fibroblasts in a myxoid stroma that can infiltrate fat or muscle bundles. It presents as a rapidly growing (<2 weeks), often tender mass (1–3 cm diameter) beneath the skin, most commonly in the forearm. It can occur at any age but is commonest in middle age. Treatment of choice is excision; resolution may still follow incomplete excision.
Solitary Bone Cyst Like Areas in Myositis Ossificans: A Breast Mass in a Child
Published in Fetal and Pediatric Pathology, 2021
Ayse Nur Akatli, Sema Uguralp, Saadet Alan, Aytac Tasci, Gokhan Yildirim
The differential diagnosis of MO includes nodular fasciitis and extraskeletal osteosarcoma. Aneurysmal cysts, bone type should be in the differential diagnosis of MO with cystic degeneration. Myositis ossificans has a zonal pattern of cellular maturation. The lesion contains myofibroblastic proliferation in the central zone, osteoid in the middle zone and mature bone in the peripheral zone [1]. In contrast, nodular fasciitis does not contain the typical zonal pattern or ossification. Osteosarcoma does not show the zonation pattern and displays a disorderly growth of hyperchromatic and atypical cells.
Orbital nodular fasciitis in the pediatric population: a case report and review of the literature
Published in Orbit, 2023
Ana Navarrete, Arie Maya, Stephanie Benshushan, Shay Ofir, Yael Deckel, Zvi Gur
Nodular fasciitis (NF) is a rare, benign spindle cell tumor formed by the nodular proliferation of connective tissue affecting the superficial fascia.1 Benign lesions may behave aggressively, growing rapidly and exerting significant mass effect on adjacent orbital structures. Although typically benign, NF lesions can transform into malignant neoplasms both clinically and histopathologically.2
Orbitofacial dermatofibrosarcoma protuberans with intranasal extension
Published in Orbit, 2018
Siti Nurhuda Sharudin, Siow Wei Tan, Nor Fadhilah Mohamad, Suresh Kumar Vasudevan, Hanizah Khairan, YC Mun, Jothi Shanmuganathan
A 25-year-old Chinese woman presented with painless swelling over the left medial canthus region for 3 months. There was no history of trauma and she had no previous significant medical illness. Initial incision biopsy done in a private center was reported as nodular fasciitis. However, the lesion recurred 3 weeks later associated with left intranasal mass.