China
Africa
Explore chapters and articles related to this topic
HPB Surgery
Published in Tjun Tang, Elizabeth O'Riordan, Stewart Walsh, Cracking the Intercollegiate General Surgery FRCS Viva, 2020
London Lucien Ooi Peng Jin, Teo Jin Yao
The US showed only intrahepatic biliary dilatation and an MRCP was then performed. The MRCP reconstructed view is as shown next. What are the considerations on this image that will help you determine the management plan?This reconstructed image of the biliary tree shows markedly dilated intrahepatic ducts with a cut off at the hilum. The right and left hepatic ductal systems also appear isolated from each other, suggesting a high level of involvement of the Klatskin tumour.It will be important to look at the 15 minute delayed views of the MRI to best define the hilar tumour and its size and extent. It is also important to establish how separated the right and left ductal systems are as this will affect both percutaneous drainage should this be needed and subsequent surgery. Regarding operability, the involvement of the vessels at the hilum, i.e. portal veins and hepatic arteries will also be important, as will the relative sizes of the various lobes of the liver.
“I Want to Die at Home„
Published in Brown Judith Belle, Challenges and Solutions: Narratives of Patient-Centered Care, 2017
Nadia had initially presented with general malaise, weakness and decreased appetite approximately eight weeks earlier. A non-tender abdominal mass was suspicious upon examination, plus Nadia was jaundiced. Abdominal ultra-sound and subsequent CT were suggestive of a cholangiocarcinoma (Klatskin tumor). The opinion of the consulting gastroenterologist was that this was an advanced tumor, with significant local spread – surgery was not an option. Nadia was then seen by oncology to determine if palliative chemotherapy or radiation would be of any benefit for symptom control and to improve her quality of life. Unfortunately, these were also determined not to be an option.
Functional Mechanism of MicroRNA-25-3p in Hilar Cholangiocarcinoma Cell Proliferation and Migration Through Regulation of Dual Specificity Phosphatase 5
Published in Journal of Investigative Surgery, 2023
Wan Zhong, Shiyang Dong, Han Wang, Chao Pan, Shiyong Yang
HCCA, also known as Klatskin tumor, is an advanced malignancy with worse patient survival that often occurs in the elderly.23 miRNAs participate in cholangiocarcinoma pathogenesis and can be used as diagnostic and prognostic biomarkers and therapeutic targets in cholangiocarcinoma.13 The changes in expression or activity of DUSP enzymes are related to human cancer.24 The current study revealed that miR-25-3p modulated G1/S phase transition of HCCA cells by targeting DUSP5, thus prompting HCCA cell proliferation, migration, and invasion.
Real-life analysis of treatment approaches and the role of inflammatory markers on survival in patients with advanced biliary tract cancer
Published in Current Medical Research and Opinion, 2022
Sabin Goktas Aydin, Burcin Cakan Demirel, Ahmet Bilici, Atakan Topcu, Musa Barış Aykan, Seda Kahraman, Ilgın Akbıyık, Muhammed Mustafa Atci, Omer Fatih Olmez, Arzu Yaren, Mehmet Ali Nahit Sendur, Caglayan Geredeli, Mesut Seker, Yuksel Urun, Nuri Karadurmus, Ahmet Aydin
Biliary tract cancers (BTC) are rare malignancies. They include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (EHC) and gallbladder cancer (GBC), which is the second most common cancer involving hepatobiliary tumors and high mortality rates1. Another BTC, an ampulla vateri tumor, has two subtypes based on its epithelium of origin: intestinal and pancreaticobiliary. A Klatskin tumor, known as a hilar cholangiocarcinoma, is localized at the confluence of the right and left hepatic bile ducts2.
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles
Published in Expert Opinion on Therapeutic Targets, 2021
Michele Simbolo, Samantha Bersani, Caterina Vicentini, Sergio V. Taormina, Chiara Ciaparrone, Fabio Bagante, Borislav Rusev, Giovanni Centonze, Marina Montresor, Matteo Brunelli, Serena Pedron, Andrea Mafficini, Gaetano Paolino, Paola Mattiolo, Simone Conci, Massimo Milione, Alfredo Guglielmi, Andrea Ruzzenente, Aldo Scarpa, Claudio Luchini
Extrahepatic cholangiocarcinoma (ECC) represents the vast majority (up to 80%) of all biliary tract cancers [1–3]. ECC is classified into two subtypes according to the anatomic site of origin: 1) perihilar cholangiocarcinoma (PHCC), also called Klatskin tumor, which arises at the confluence of the left and right hepatic ducts, and 2) distal extrahepatic cholangiocarcinoma (DECC), which originates from the common bile duct [2,4].