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Uterine Cancer
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Claudia von Arx, Hani Gabra, Christina Fotopoulou
Malignant uterine epithelial tumors have an endometrioid growth pattern. There are two main types of EC. Type I, estrogen-related, usually presents histologically as a low-grade endometrioid tumor and is associated with atypical endometrial hyperplasia. These tumors account for approximately 80% of all ECs, and usually, they have a good prognosis. Type II tumors, non-estrogen-related, include Grade 3 endometrioid tumors as well as tumors of non-endometrioid histology, namely serous, clear cell, mucinous, squamous, transitional cell, mesonephric, and undifferentiated carcinoma. These account for 10–20% of EC, and they often have a poor prognosis. A precursor lesion is rarely identified for Type II tumors. Patients presenting with Type II tumors are often older and multiparous.18
Ovarian Neoplasms
Published in Victor A. Bernstam, Pocket Guide to GENE LEVEL DIAGNOSTICS in Clinical Practice, 2019
Homozygous deletion of the RB gene has been implicated in the aggressive biological behavior of an endometrioid tumor of the ovary of low malignant potential30% of the informative cases of various ovarian neoplasms [leiomyosarcoma, sex cord-stromal tumor, and epithelial carcinomas (mucinous, endometrioid, mixed Müllerian, and serous) and their metastases]
Endometrial cancer
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2014
Christina Fotopoulou, Hani Gabra
The most common type of EC has an endometrioid growth pattern (75%–80%). There are two main types of EC: Type-I, estrogen-related, which usually presents histologically as a low-grade endometrioid tumour and is associated with atypical endometrial hyperplasia. These comprise approximately 80% of all endometrial carcinomas. Risk factors for type I include obesity, nulliparity, endogenous or exogenous estrogen excess, diabetes mellitus and hypertension. Type-II tumours account for 10%–20% of EC. They include grade 3 endometrioid tumours as well as tumours of non-endometrioid histology: serous, clear cell, mucinous, squamous, transitional cell, mesonephric and undifferentiated types. These tumours have often a poor prognosis, and are not clearly associated with estrogen stimulation. A precursor lesion is rarely identified. These patients are often older and multiparous, while obesity, diabetes, or hypertension do not predispose to this type of endometrial carcinoma.13
Factor affecting lymph node metastasis in uterine papillary serous carcinomas: a retrospective analysis
Published in Journal of Obstetrics and Gynaecology, 2022
Elif Ceren Tutkun Kilinc, Vakkas Korkmaz, Hakan Rasit Yalcin
Cytology positivity ranges between 5 and 10% in early-stage endometrial malignancies, and when all stages are examined, the majority of patients with positive cytology findings have a high-grade, non-endometrioid tumour. Garg et al. investigated predictive factors associated with LNM and found that the rate of LNM rose sixfold in individuals with serous histology and cytology positive (Garg et al.2013). Boyraz et al. analysed 182 UPSC patients and observed cytology positivity in eight patients and LVSI (+) and extra-uterine spread in all of these patients. In comparison to the group without extra-uterine illness, it was observed that LVSI, a high Ca-125 level, and cytology positive were related to metastases (Boyraz et al.2017). Other researches have produced similar findings (Saga et al.2006, Taskiran et al.2006).
Post-recurrence survival analysis of patients with pulmonary recurrence from gynaecologic cancers: a multi-institutional analysis of 122 patients
Published in Journal of Obstetrics and Gynaecology, 2022
Burak Ersak, Serra Akar, Gökhan Demirayak, Abdurrahman Alp Tokalioğlu, Okan Aytekin, Caner Çakir, Dilek Yüksel, Nedim Tokgözoğlu, Sema Karakaş, Ayşe Büşra Önder, Fatih Çelik, Sevgi Ayhan, Mehmet Ünsal, Nurettin Boran, Fatih Kiliç, Günsu Kimyon Cömert, Işın Üreyen, Tayfun Toptaş, Vakkas Korkmaz, İsa Aykut Özdemir, Tolga Taşçi, Osman Türkmen, Özlem Moraloğlu Tekin, Yaprak Engin-Üstün, Taner Turan
Dowdy et al. (2007) concluded that there was no relationship between histologic subtype and survival after isolated PR among patients with endometrial cancer. Turan et al. (2016) reported that endometrioid tumour type was a borderline predictor for improved prognosis; however, tumour type was not statistically significant. In our study, univariate analyses were conducted to assess if associations between PRS and primary organ differed by histologic subtype; owing to our groups, histologic subtype was classified as either serous or non-serous subtypes. No statistically significant difference was observed in terms of PRS concerning the serous and non-serous subtypes.
Concomitant endometriosis in malignant and borderline ovarian tumours*
Published in Journal of Obstetrics and Gynaecology, 2018
Engin Oral, Ovgu Aydin, Banu Aygun Kumbak, Sennur İlvan, Handan Yilmaz, Esra Tustas, Tugan Bese, Fuat Demirkiran, Macit Arvas
During the years 1995–2011, a total of 661 women with ovarian tumours (530 malignant ovarian tumour and 131 BOT) were retrospectively analysed. Serous adenocarcinoma was the most frequently encountered histological subtype (233 women, 35%). The other histologies were mixed tumours (87 women, 13%), endometrioid carcinoma (55 women, 8%), mucinous carcinoma (42 women, 6%), clear cell carcinoma (27 women, 4%), borderline mucinous tumour (68 women, 10%), borderline serous tumour (54 women, 8%), borderline endometrioid tumour (five women, 0.8%), borderline clear cell tumour (one woman, 0.2%), borderline mixed type tumour (three women, 0.5%) and others (86 women, 13%).